DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ERp60 and PDIA3

DIOPT Version :9

Sequence 1:	NP_725084.2	Gene:	ERp60 / 36270	FlyBaseID:	FBgn0033663	Length:	489	Species:	Drosophila melanogaster
Sequence 2:	NP_005304.3	Gene:	PDIA3 / 2923	HGNCID:	4606	Length:	505	Species:	Homo sapiens

Alignment Length:	503	Identity:	242/503 - (48%)
Similarity:	321/503 - (63%)	Gaps:	30/503 - (5%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 RLA---GVLLLGFIAISSGAEQDVLELGDDDFATTLKQHETT---LVMFYAPWCGHCKRLKPEYA 62
            |||   ||.|| ..|....|..|||||.||:|.:.:....:.   ||.|:||||||||||.|||.
Human     5 RLALFPGVALL-LAAARLAAASDVLELTDDNFESRISDTGSAGLMLVEFFAPWCGHCKRLAPEYE 68

  Fly    63 KAAEIVKDDDPPIKLAKVDCTEAGKETCSKYSVSGYPTLKIFRQDEVSQDYNGPREASGIAKYMR 127
            .||..:|...|   ||||||| |...||:||.|||||||||||..|.:..|:|||.|.||..:::
Human    69 AAATRLKGIVP---LAKVDCT-ANTNTCNKYGVSGYPTLKIFRDGEEAGAYDGPRTADGIVSHLK 129

  Fly   128 AQVGPASKTVRTVAELKKFLDTKDTTLFGYFSDSDSKLAKIFLKFADKNREKYRFGHSSEKEVL- 191
            .|.||||..:||..|.|||:..||.::.|:|.||.|:....|||.|...|:.|||.|::.:.::
Human   130 KQAGPASVPLRTEEEFKKFISDKDASIVGFFDDSFSEAHSEFLKAASNLRDNYRFAHTNVESLVN 194

  Fly   192 --DKQGETDKIVLIRAPHLSNKFESSSIKF--EGSSESDLSTFVKENFHGLVGHRTQDSVKDF-- 250
              |..||  .|:|.|..||:||||..::.:  :..:...:..|::||..|:..|.|:|: ||.
Human   195 EYDDNGE--GIILFRPSHLTNKFEDKTVAYTEQKMTSGKIKKFIQENIFGICPHMTEDN-KDLIQ 256

  Fly   251 QNPLITAYYSVDYQKNPKGTNYWRNRVLKVAKEFVG---QINFAIASKDDFQHELNEYGYD-FVG 311
            ...|:.|||.|||:||.||:|||||||:.|||:|:.   ::|||:||:..|.|||:::|.: ..|
Human   257 GKDLLIAYYDVDYEKNAKGSNYWRNRVMMVAKKFLDAGHKLNFAVASRKTFSHELSDFGLESTAG 321

  Fly   312 DKPVVLARDEKNLKYALKDEFSVEN--LQDFVEKLLANELEPYIKSEPIPESNDAPVKVAVAKNF 374
            :.|||..|..|..|:.:::|||.:.  |:.|::......|:.|:||||||||||.||||.||:||
Human   322 EIPVVAIRTAKGEKFVMQEEFSRDGKALERFLQDYFDGNLKRYLKSEPIPESNDGPVKVVVAENF 386

  Fly   375 DDLVINNGKDTLIEFYAPWCGHCKKLSPIYEELAEKL-QDEDVAIVKMDATANDVPPEFNVRGFP 438
            |::|.|..||.|||||||||||||.|.|.|:||.||| :|.::.|.||||||||||..:.|||||
Human   387 DEIVNNENKDVLIEFYAPWCGHCKNLEPKYKELGEKLSKDPNIVIAKMDATANDVPSPYEVRGFP 451

  Fly   439 TLFWLPKDAKNKPVSYNGGREVDDFLKYIAKEATTELKGFDRSGKPKK 486
            |:::.|.:.|..|..|.||||:.||:.|:.:|||.  ....:..||||
Human   452 TIYFSPANKKLNPKKYEGGRELSDFISYLQREATN--PPVIQEEKPKK 497

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ERp60	NP_725084.2	ER_PDI_fam	23..479	CDD:273457	229/472 (49%)
		PDI_a_PDIR	23..126	CDD:239295	59/105 (56%)
		PDI_b_ERp57	133..235	CDD:239367	38/106 (36%)
		PDI_b'_ERp72_ERp57	239..345	CDD:239371	49/113 (43%)
		PDI_a_PDI_a'_C	365..467	CDD:239293	62/102 (61%)
PDIA3	NP_005304.3	YbbN	25..487	CDD:331940	229/470 (49%)
PDIA3	NP_005304.3	ER retention motif	502..505
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165156389
Domainoid	1	1.000	137	1.000	Domainoid score	I4914
eggNOG	1	0.900	-	-		E2759_KOG0190
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H68454
Inparanoid	1	1.050	438	1.000	Inparanoid score	I1693
Isobase	1	0.950	-	0	Normalized mean entropy	S1476
OMA	1	1.010	-	-		QHG53639
OrthoDB	1	1.010	-	-		D222522at33208
OrthoFinder	1	1.000	-	-		FOG0000292
OrthoInspector	1	1.000	-	-		oto89737
orthoMCL	1	0.900	-	-		OOG6_100478
Panther	1	1.100	-	-	LDO	PTHR18929
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2224
SonicParanoid	1	1.000	-	-		X241
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	17	16.750