Protein Alignment ERp60 and Pdia2

DIOPT Version :10

• Sequence 1: NP_725084.2
• Gene: ERp60 / 36270
• FlyBaseID: FBgn0033663
• Length: 489
• Species: Drosophila melanogaster
• Sequence 2: NP_001099245.2
• Gene: Pdia2 / 287164
• RGDID: 1305164
• Length: 527
• Species: Rattus norvegicus
• Alignment Length: 480
• Identity: 152/480 - (31%)
• Similarity: 239/480 - (49%)
• Gaps: 43/480 - (8%)

  Fly    21 EQDVLELGDDDFATTLKQHETTLVMFYAPWCGHCKRLKPEYAKAAEIVKDDDPPIKLAKVDCTEA 85
            |..:|.|.:...:..|::|...:|.||||||||||.|.|||:|||.::..:...:.||||| ..|
  Rat    44 EDGILVLNNQTLSLALQEHSALMVEFYAPWCGHCKALAPEYSKAAALLAAESAAVTLAKVD-GPA 107

  Fly    86 GKETCSKYSVSGYPTLKIFRQDEVS--QDYNGPREASGIAKYMRAQVGPASKTVRTVAELKKFLD 148
            ..|...::.|.||||||.|:....:  ::|.||:.|.|||:::|.:|||::..:.....::..:.
  Rat   108 EPELTKEFGVVGYPTLKFFQNGNRTNPEEYIGPKTAEGIAEWLRRRVGPSATRLEDEEGVQALMA 172

  Fly   149 TKDTTLFGYFSDSDSKLAKIFLKFADKNREKYRFGHSSEKEVLDKQGET-DKIVLIRAPHLSNKF 212
            ..|..:.|:|.|...:....||..| ::.....||.:.:.::.:|.|.| |.:||.:      ||
  Rat   173 KWDMVVIGFFQDLQEEDVATFLALA-RDALDMAFGFTDQPQLFEKFGLTKDTVVLFK------KF 230

  Fly   213 ESSSIKFEGSSES-----DLSTF-VKENFHGLVGHRTQDSVKDFQ----NPLITAYYSVDYQKNP 267
            :.....|....|:     |||.| :..:.|.:....:|.|.|.|.    |.|:........|...
  Rat   231 DEGRADFPVDKEAGLDLGDLSRFLITHSMHLVTEFNSQTSPKIFAARILNHLLLFVNQTLAQHRE 295

  Fly   268 KGTNYWRNRVLKVAKEFVGQINFAIAS-KDDFQHELNEYGYDFVGDKPVVLARDEKNLKYALKD- 330
            ..|.:     .:.|..|.||:.|.:.. ..|..|.||.:|........:.|...|...|||...
  Rat   296 LLTGF-----REAAPPFRGQVLFVMVDVAADNSHVLNYFGLKAEEAPTLRLINVETTKKYAPAGV 355

  Fly   331 -EFSVENLQDFVEKLLANELEPYIKSEPIPESND-APVKVAVAKNFDDLVINNGKDTLIEFYAPW 393
             ..:..::..|.:.:|..|::.|:.|:.||...| .|||..|:|||:.:..:..|:..::|||||
  Rat   356 IPITAASVAAFCQAVLHGEVKHYLLSQEIPPDWDQRPVKTLVSKNFEQVAFDETKNVFVKFYAPW 420

  Fly   394 CGHCKKLSPIYEELAEKLQD-EDVAIVKMDATANDVPPEFNVRGFPTLFWLPKDAKNKPVSYNGG 457
            |.|||:::|.:|.||||.:| ||:.|.:||||||:: ..|:|.|:|||.:.|.....|.:.|...
  Rat   421 CSHCKEMAPAWEALAEKYRDREDIVIAEMDATANEL-EAFSVHGYPTLKFFPAGPDRKIIEYKST 484

  Fly   458 REVDDFLKYIAKEATTELKGFDRSG 482
            |:::.|.|::           ||.|
  Rat   485 RDLETFSKFL-----------DRGG 498

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ERp60	NP_725084.2	ER_PDI_fam	23..479	CDD:273457	148/473 (31%)
Pdia2	NP_001099245.2	ER_PDI_fam	45..506	CDD:273457	151/479 (32%)