DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ERp60 and SPAC1F5.02

DIOPT Version :9

Sequence 1:	NP_725084.2	Gene:	ERp60 / 36270	FlyBaseID:	FBgn0033663	Length:	489	Species:	Drosophila melanogaster
Sequence 2:	NP_592871.1	Gene:	SPAC1F5.02 / 2541460	PomBaseID:	SPAC1F5.02	Length:	492	Species:	Schizosaccharomyces pombe

Alignment Length:	504	Identity:	166/504 - (32%)
Similarity:	254/504 - (50%)	Gaps:	83/504 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly     9 LLLGFIAISSG---AEQDVLELGDDDFATTLKQHETTLVMFYAPWCGHCKRLKPEYAKAAEIVKD 70
            ||..|:|.|.|   |..:|.::..:.....:...:..:|.||||||||||.|.|||..||:.::.
pombe     6 LLAAFLAFSGGFFCASAEVPKVNKEGLNELITADKVLMVKFYAPWCGHCKALAPEYESAADELEK 70

  Fly    71 DDPPIKLAKVDCTEAGKETCSKYSVSGYPTLKIFRQDEVSQDYNGPREASGIAKYMRAQVGPASK 135
            |.  |.|.:|||||.| :.||:||:.|||||.:|:..:....|:|||:...:.||||.|:.|
pombe    71 DG--ISLVEVDCTEEG-DLCSEYSIRGYPTLNVFKNGKQISQYSGPRKHDALVKYMRKQLLP--- 129

  Fly   136 TVRTVAE--LKKFLD-TKDTTLFGYFSDSDSKLAKIFLKFADKNREKYRFGHSSEKEVLDKQG-- 195
            ||:.:::  |:.|:: ..|..:..:|  .|.||...:.:.|:..::.:.|..|.:||:....|
pombe   130 TVKPISKDTLENFVEKADDLAVVAFF--KDQKLNDTYTEVAEVMKDDFVFAASDDKELAKSLGSN 192

  Fly   196 -------------ETDKIVLIRAPHLSNKFESSSI-KFEGSS------ESDLSTFVKENFHGLV- 239
                         ::||:|      .:..::.:|| .|.|.|      |.:..||.|....||.
pombe   193 FPGIVAFTKDAAQDSDKLV------YTGDWDPASIADFIGVSSIPLLDELNQMTFGKYQQSGLPL 251

  Fly   240 ------GHRTQDSVKDFQNPLITAYYSVDYQKNPKGTNYWRNRVLKVAKEFVGQINFAIASKDDF 298
                  ...::|.:.|...||...|..                .|:.|  |:..:.:...:|
pombe   252 GIIFYNSTESRDELYDVFQPLAKKYQD----------------TLRFA--FLDAVRYGAVAK--- 295

  Fly   299 QHELNEYGYDFVGDKPV-VLARDEKNLKYAL-KDEFSVENLQDFVEKLLANELEPYIKSEPIPES 361
              ::|     ...|.|. |:|..:..|||.. ..|.:.:.:..||...:..:|:|.|||:|||||
pombe   296 --QMN-----VESDWPAFVIANLKSMLKYPFPTTELTAKAMTKFVGDFVDGKLQPKIKSQPIPES 353

  Fly   362 NDAPVKVAVAKNFDDLVINNGKDTLIEFYAPWCGHCKKLSPIYEELAEKLQDE-DVAIVKMDATA 425
            .:..| |.||.||||:|::..||.|:|||||||||||.|:|.||:|||:..|: :|.:.|:|||.
pombe   354 QEDLV-VLVADNFDDIVMDETKDVLVEFYAPWCGHCKNLAPTYEKLAEEYSDDSNVVVAKIDATE 417

  Fly   426 NDVPPEFNVRGFPTLFWLPKDAKNKPVSYNGGREVDDFLKYIAKEATTE 474
            ||:  ..::.||||:.:...:.|..||.|.|.|.::|...:|.|.|:.|
pombe   418 NDI--SVSISGFPTIMFFKANDKVNPVRYEGDRTLEDLSAFIDKHASFE 464

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ERp60	NP_725084.2	ER_PDI_fam	23..479	CDD:273457	159/487 (33%)
		PDI_a_PDIR	23..126	CDD:239295	42/102 (41%)
		PDI_b_ERp57	133..235	CDD:239367	27/126 (21%)
		PDI_b'_ERp72_ERp57	239..345	CDD:239371	20/114 (18%)
		PDI_a_PDI_a'_C	365..467	CDD:239293	49/102 (48%)
SPAC1F5.02	NP_592871.1	ER_PDI_fam	23..464	CDD:273457	158/485 (33%)
		pdi_dom	27..126	CDD:273454	44/101 (44%)
		PDI_b_family	135..225	CDD:239279	18/97 (19%)
		PDI_b'_family	237..337	CDD:239280	25/127 (20%)
		PDI_a_PDI_a'_C	358..457	CDD:239293	49/101 (49%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	97	1.000	Domainoid score	I1894
eggNOG	1	0.900	-	-		E2759_KOG0190
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG53639
OrthoFinder	1	1.000	-	-		FOG0000292
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100478
Panther	1	1.100	-	-	O	PTHR18929
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2224
SonicParanoid	1	1.000	-	-		X241
TreeFam	1	0.960	-	-
	11	10.810