DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ERp60 and PDILT

DIOPT Version :9

Sequence 1:	NP_725084.2	Gene:	ERp60 / 36270	FlyBaseID:	FBgn0033663	Length:	489	Species:	Drosophila melanogaster
Sequence 2:	NP_777584.1	Gene:	PDILT / 204474	HGNCID:	27338	Length:	584	Species:	Homo sapiens

Alignment Length:	510	Identity:	122/510 - (23%)
Similarity:	208/510 - (40%)	Gaps:	101/510 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly    21 EQDVLELGDDDFATTLKQHETTLVMFYAPWCGHCKRLKPEYAKAAEIVKDDDPPIKLAKVDCTEA 85
            |:.:|.|........|.|....:|:|:.|.....:.|..|..||.||:......|...|||.| .
Human    42 ERSLLVLTPAGLTQMLNQTRFLMVLFHNPSSKQSRNLAEELGKAVEIMGKGKNGIGFGKVDIT-I 105

  Fly    86 GKETCSKYSVSGYPTLKIFRQDEVSQDYN--GPREASGIAKYMRAQVGPASKTVRTVAELKKFLD 148
            .||...::.::..|.||:|.:...|:..:  |..|::.:..::|.|:...:....:..::.:|:.
Human   106 EKELQQEFGITKAPELKLFFEGNRSEPISCKGVVESAALVVWLRRQISQKAFLFNSSEQVAEFVI 170

  Fly   149 TKDTTLFGYFSDSDSKLAKIF---------LKFA---------------DK----------NREK 179
            ::...:.|:|.|.:.::|::|         |.|.               |.          ||:|
Human   171 SRPLVIVGFFQDLEEEVAELFYDVIKDFPELTFGVITIGNVIGRFHVTLDSVLVFKKGKIVNRQK 235

  Fly   180 YRFGHSSEKEVLD---KQGETDKIV--------LIRAPHLSNKFESSSIKF-EGSSESDLSTFVK 232
            . ...|:.|:.|:   ||..||.::        ||...|:.    |..:.| ..||||
Human   236 L-INDSTNKQELNRVIKQHLTDFVIEYNTENKDLISELHIM----SHMLLFVSKSSES------- 288

  Fly   233 ENFHGLVGHRTQDSVKDFQNPLITAYYSVDYQKNPKGTNYWRNRVLKVAKEFVGQINFAIASKDD 297
               :|::....:.:.|:|||.::......|..:|.:...|:  ||.:|....|..:|.:
Human   289 ---YGIIIQHYKLASKEFQNKILFILVDADEPRNGRVFKYF--RVTEVDIPSVQILNLS------ 342

  Fly   298 FQHELNEYGYDFVGDKPVVLARDEKNLKYAL-KDEFSVENLQDFVEKLLANELEPYIKSEPIPES 361
                                    .:.:|.: .|:.:.|:|:.|....|:.....:..||.||:.
Human   343 ------------------------SDARYKMPSDDITYESLKKFGRSFLSKNATKHQSSEEIPKY 383

  Fly   362 ND-APVKVAVAKNFDDLVINNGKDTLIEFYAPWCGHCKKLSPIYEELAEKLQDED-VAIVKMDAT 424
            .| ..||..|.|||:.:|.:..||..:.|||||...||.|.|:.|||..|.|:.. :.|.|:|.|
Human   384 WDQGLVKQLVGKNFNVVVFDKEKDVFVMFYAPWSKKCKMLFPLLEELGRKYQNHSTIIIAKIDVT 448

  Fly   425 ANDVPPEFNVRGFPTLFWLPKDAKNKPVSYNGGREVDDFLKYIAKEATTELKGFD 479
            |||:...:..| :| .|.|......:.|.|.|...:..|..::.....|:::..|
Human   449 ANDIQLMYLDR-YP-FFRLFPSGSQQAVLYKGEHTLKGFSDFLESHIKTKIEDED 501

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ERp60	NP_725084.2	ER_PDI_fam	23..479	CDD:273457	120/506 (24%)
		PDI_a_PDIR	23..126	CDD:239295	27/104 (26%)
		PDI_b_ERp57	133..235	CDD:239367	28/147 (19%)
		PDI_b'_ERp72_ERp57	239..345	CDD:239371	17/106 (16%)
		PDI_a_PDI_a'_C	365..467	CDD:239293	38/102 (37%)
PDILT	NP_777584.1	YbbN	46..501	CDD:331940	120/504 (24%)
PDILT	NP_777584.1	Prevents secretion from ER. /evidence=ECO:0000255\|PROSITE-ProRule:PRU10138	581..584
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165156388
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D222522at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.850