DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment ERp60 and P4hb

DIOPT Version :9

Sequence 1:	NP_725084.2	Gene:	ERp60 / 36270	FlyBaseID:	FBgn0033663	Length:	489	Species:	Drosophila melanogaster
Sequence 2:	NP_035162.1	Gene:	P4hb / 18453	MGIID:	97464	Length:	509	Species:	Mus musculus

Alignment Length:	498	Identity:	171/498 - (34%)
Similarity:	261/498 - (52%)	Gaps:	33/498 - (6%)

- Green bases have known domain annotations that are detailed below.

  Fly     5 LAGVLLLGFIAISSGAEQDVLELGDDDFATTLKQHETTLVMFYAPWCGHCKRLKPEYAKAAEIVK 69
            ||....:|..|:..  |.:||.|...:|...|..|:..||.||||||||||.|.|||||||..:|
Mouse    11 LAWAARVGADALEE--EDNVLVLKKSNFEEALAAHKYLLVEFYAPWCGHCKALAPEYAKAAAKLK 73

  Fly    70 DDDPPIKLAKVDCTEAGKETCSKYSVSGYPTLKIFRQDEVS--QDYNGPREASGIAKYMRAQVGP 132
            .:...|:|||||.||. .:...:|.|.||||:|.|:..:.:  ::|...|||..|..:::.:.||
Mouse    74 AEGSEIRLAKVDATEE-SDLAQQYGVRGYPTIKFFKNGDTASPKEYTAGREADDIVNWLKKRTGP 137

  Fly   133 ASKTVRTVAELKKFLDTKDTTLFGYFSDSDSKLAKIFLKFADKNREKYRFGHSSEKEVLDK-QGE 196
            |:.|:...|..:..:|:.:.|:.|:|.|.:|..||.|| .|.:..:...||.:|...|..| |.:
Mouse   138 AATTLSDTAAAESLVDSSEVTVIGFFKDVESDSAKQFL-LAAEAIDDIPFGITSNSGVFSKYQLD 201

  Fly   197 TDKIVLIRAPHLSNKFESSSIKFEGS-SESDLSTFVKENFHGLVGHRTQDSVKDFQNPLITAYYS 260
            .|.:||.:      ||:.....|||. ::..|..|:|.|...||...|:.:........|..:..
Mouse   202 KDGVVLFK------KFDEGRNNFEGEITKEKLLDFIKHNQLPLVIEFTEQTAPKIFGGEIKTHIL 260

  Fly   261 VDYQKNPKGTNYWRNRVLKVAKEFVGQINFAIASKDDFQHELNEYGYDFVGDK----PVV--LAR 319
            :...|:....:...:...:.|:.|.|:|.|.....|   |..|:...:|.|.|    |.|  :..
Mouse   261 LFLPKSVSDYDGKLSSFKRAAEGFKGKILFIFIDSD---HTDNQRILEFFGLKKEECPAVRLITL 322

  Fly   320 DEKNLKYALK-DEFSVENLQDFVEKLLANELEPYIKSEPIPESND-APVKVAVAKNFDDLVINNG 382
            :|:..||..: ||.:.|.:.:|..:.|..:::|::.|:.:||..| .||||.|..||:::..:..
Mouse   323 EEEMTKYKPESDELTAEKITEFCHRFLEGKIKPHLMSQEVPEDWDKQPVKVLVGANFEEVAFDEK 387

  Fly   383 KDTLIEFYAPWCGHCKKLSPIYEELAEKLQD-EDVAIVKMDATANDVPPEFNVRGFPTLFWLPKD 446
            |:..:|||||||||||:|:||:::|.|..:| |::.|.|||:|||:| ....|..||||.:.|..
Mouse   388 KNVFVEFYAPWCGHCKQLAPIWDKLGETYKDHENIIIAKMDSTANEV-EAVKVHSFPTLKFFPAS 451

  Fly   447 AKNKPVSYNGGREVDDFLKYIAKEATTELKGFDRSGKPKKTEL 489
            |....:.|||.|.:|.|.|::      |..|.|.:|..:..:|
Mouse   452 ADRTVIDYNGERTLDGFKKFL------ESGGQDGAGDDEDLDL 488

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ERp60	NP_725084.2	ER_PDI_fam	23..479	CDD:273457	163/468 (35%)
		PDI_a_PDIR	23..126	CDD:239295	48/104 (46%)
		PDI_b_ERp57	133..235	CDD:239367	31/103 (30%)
		PDI_b'_ERp72_ERp57	239..345	CDD:239371	24/112 (21%)
		PDI_a_PDI_a'_C	365..467	CDD:239293	48/102 (47%)
P4hb	NP_035162.1	ER_PDI_fam	26..476	CDD:273457	162/467 (35%)
		Thioredoxin_like	31..135	CDD:294274	46/104 (44%)
		PDI_b_family	139..234	CDD:239279	30/101 (30%)
		PDI_b'_family	246..349	CDD:239280	22/105 (21%)
		PDI_a_PDI_a'_C	370..472	CDD:239293	48/102 (47%)
		Prevents secretion from ER	506..509
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167846778
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0190
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG53639
OrthoDB	1	1.010	-	-		D222522at33208
OrthoFinder	1	1.000	-	-		FOG0000292
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100478
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2224
SonicParanoid	1	1.000	-	-		X241
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	9	8.690