Protein Alignment ERp60 and pdi-3

DIOPT Version :10

• Sequence 1: NP_725084.2
• Gene: ERp60 / 36270
• FlyBaseID: FBgn0033663
• Length: 489
• Species: Drosophila melanogaster
• Sequence 2: NP_491995.1
• Gene: pdi-3 / 172433
• WormBaseID: WBGene00003964
• Length: 488
• Species: Caenorhabditis elegans
• Alignment Length: 496
• Identity: 252/496 - (50%)
• Similarity: 341/496 - (68%)
• Gaps: 15/496 - (3%)

  Fly     1 MMWRLAGVLLLGFIAISS--GAEQDVLELGDDDFATTLKQHETTLVMFYAPWCGHCKRLKPEYAK 63
            |:| :...|:..|:|.:|  ||   |||..|.:|...::.|:..||.||||||||||::.|||.:
 Worm     1 MIW-VQAALVASFLAFASAGGA---VLEYTDGNFDDLIQTHDIALVKFYAPWCGHCKKIAPEYER 61

  Fly    64 AAEIVKDDDPPIKLAKVDCTEAGKETCSKYSVSGYPTLKIFRQDEVSQDYNGPREASGIAKYMRA 128
            ||..:..:|||:.|.||||| ..|..|.|:.|.|:|||||||....:|||:|||:|.||.|:||.
 Worm    62 AAPKLASNDPPVALVKVDCT-TEKTVCDKFGVKGFPTLKIFRNGVPAQDYDGPRDADGIVKFMRG 125

  Fly   129 QVGPASKTVRTVAELKKFLDTKDTTLFGYFSDSDSKLAKIFLKFADKNREKYRFGHSSEKEVLDK 193
            |.||:||.::||||.:||....:..:.|:| :|:|||...:||.||..|:::.|.|:|.|:::.|
 Worm   126 QSGPSSKELKTVAEFEKFTGGDENVVIGFF-ESESKLKDSYLKVADTERDRFSFAHTSNKDIIKK 189

  Fly   194 QGETDKIVLIRAPHLSNKFESSSIKFEGSSESD-LSTFVKENFHGLVGHRTQDSVKDF-QNPLIT 256
            .|.:|.:|:.....|.|||:::..|::|:.::| :..|:.....|..|.|||.::..| |.|::.
 Worm   190 AGYSDDVVVFVPKKLHNKFDTNEFKYDGNYDTDKIKNFLVHETVGFAGIRTQGNLFQFEQKPIVI 254

  Fly   257 AYYSVDYQKNPKGTNYWRNRVLKVAKEFVGQINFAIASKDDFQHEL--NEYGYDFVGDKPVVLAR 319
            .||:|||.|:|||:|||||||||||:.:..::.||:::|::|..|:  |..|.....|||:|...
 Worm   255 VYYNVDYVKDPKGSNYWRNRVLKVAQNYKRKVQFAVSNKEEFSSEIETNGLGERKDSDKPIVAIL 319

  Fly   320 DEKNLKYALKDEFSVENLQDFVEKLLANELEPYIKSEPIPESNDAPVKVAVAKNFDDLVINNGKD 384
            ..:. ||.:..||||:|||.||:::||...|||:||||||: ....|||||.|||.:|:::..||
 Worm   320 TNEG-KYPMDQEFSVDNLQQFVDEVLAGNAEPYMKSEPIPD-EQGDVKVAVGKNFKELIMDADKD 382

  Fly   385 TLIEFYAPWCGHCKKLSPIYEELAEKLQDEDVAIVKMDATANDVPPEFNVRGFPTLFWLPKDAKN 449
            .|||||||||||||.|:|.||||||||..|||.|.|||||||||||.|.||||||||||||:||:
 Worm   383 VLIEFYAPWCGHCKSLAPKYEELAEKLNKEDVIIAKMDATANDVPPMFEVRGFPTLFWLPKNAKS 447

  Fly   450 KPVSYNGGREVDDFLKYIAKEATTELKGFDRSG-KPKKTEL 489
            .|:.|||||||.||:.:|:|.:|..||||.|.| |.|||||
 Worm   448 NPIPYNGGREVKDFVSFISKHSTDGLKGFSRDGKKKKKTEL 488

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ERp60	NP_725084.2	ER_PDI_fam	23..479	CDD:273457	235/459 (51%)
pdi-3	NP_491995.1	ER_PDI_fam	21..477	CDD:273457	236/462 (51%)