DRSC/TRiP Functional Genomics Resources

powered by:
logo

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment ERp60 and Pdia3

DIOPT Version :9

Sequence 1:NP_725084.2 Gene:ERp60 / 36270 FlyBaseID:FBgn0033663 Length:489 Species:Drosophila melanogaster
Sequence 2:NP_031978.2 Gene:Pdia3 / 14827 MGIID:95834 Length:505 Species:Mus musculus


Alignment Length:499 Identity:234/499 - (46%)
Similarity:318/499 - (63%) Gaps:27/499 - (5%)


- Green bases have known domain annotations that are detailed below.


  Fly     5 LAGVLLLGFIAISSGAEQDVLELGDDDFATTLKQHETT---LVMFYAPWCGHCKRLKPEYAKAAE 66
            |.||.|| ..:....|..|||||.|::|.:.:....:.   ||.|:||||||||||.|||..||.
Mouse     9 LPGVALL-LASARLAAASDVLELTDENFESRVSDTGSAGLMLVEFFAPWCGHCKRLAPEYEAAAT 72

  Fly    67 IVKDDDPPIKLAKVDCTEAGKETCSKYSVSGYPTLKIFRQDEVSQDYNGPREASGIAKYMRAQVG 131
            .:|...|   ||||||| |...||:||.|||||||||||..|.:..|:|||.|.||..:::.|.|
Mouse    73 RLKGIVP---LAKVDCT-ANTNTCNKYGVSGYPTLKIFRDGEEAGAYDGPRTADGIVSHLKKQAG 133

  Fly   132 PASKTVRTVAELKKFLDTKDTTLFGYFSDSDSKLAKIFLKFADKNREKYRFGHSSEKEVL---DK 193
            |||..:||..|.|||:..||.::.|:|.|..|.....|||.|...|:.|||.|::.:.::   |.
Mouse   134 PASVPLRTEEEFKKFISDKDASVVGFFRDLFSDGHSEFLKAASNLRDNYRFAHTNIESLVKEYDD 198

  Fly   194 QGETDKIVLIRAPHLSNKFESSSIKF--EGSSESDLSTFVKENFHGLVGHRTQDSVKDF--QNPL 254
            .||  .|.:.|..||:||||..::.:  :..:...:..|::::..||..|.|:|: ||.  ...|
Mouse   199 NGE--GITIFRPLHLANKFEDKTVAYTEKKMTSGKIKKFIQDSIFGLCPHMTEDN-KDLIQGKDL 260

  Fly   255 ITAYYSVDYQKNPKGTNYWRNRVLKVAKEFVG---QINFAIASKDDFQHELNEYGYD-FVGDKPV 315
            :||||.|||:||.||:|||||||:.|||:|:.   ::|||:||:..|.|||:::|.: ..|:.||
Mouse   261 LTAYYDVDYEKNAKGSNYWRNRVMMVAKKFLDAGHKLNFAVASRKTFSHELSDFGLESTTGEVPV 325

  Fly   316 VLARDEKNLKYALKDEFSVEN--LQDFVEKLLANELEPYIKSEPIPESNDAPVKVAVAKNFDDLV 378
            |..|..|..|:.:::|||.:.  |:.|:::.....|:.|:|||||||||:.||||.||:||||:|
Mouse   326 VAIRTAKGEKFVMQEEFSRDGKALEQFLQEYFDGNLKRYLKSEPIPESNEGPVKVVVAENFDDIV 390

  Fly   379 INNGKDTLIEFYAPWCGHCKKLSPIYEELAEKL-QDEDVAIVKMDATANDVPPEFNVRGFPTLFW 442
            ....||.|||||||||||||.|.|.|:||.||| :|.::.|.||||||||||..:.|:||||:::
Mouse   391 NEEDKDVLIEFYAPWCGHCKNLEPKYKELGEKLSKDPNIVIAKMDATANDVPSPYEVKGFPTIYF 455

  Fly   443 LPKDAKNKPVSYNGGREVDDFLKYIAKEATTELKGFDRSGKPKK 486
            .|.:.|..|..|.||||::||:.|:.:|||.  ....:..||||
Mouse   456 SPANKKLTPKKYEGGRELNDFISYLQREATN--PPIIQEEKPKK 497

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
ERp60NP_725084.2 ER_PDI_fam 23..479 CDD:273457 224/472 (47%)
PDI_a_PDIR 23..126 CDD:239295 58/105 (55%)
PDI_b_ERp57 133..235 CDD:239367 35/106 (33%)
PDI_b'_ERp72_ERp57 239..345 CDD:239371 50/113 (44%)
PDI_a_PDI_a'_C 365..467 CDD:239293 61/102 (60%)
Pdia3NP_031978.2 ER_PDI_fam 26..487 CDD:273457 224/469 (48%)
Thioredoxin 27..131 CDD:278513 57/107 (53%)
PDI_b_ERp57 135..240 CDD:239367 35/106 (33%)
PDI_b'_ERp72_ERp57 244..357 CDD:239371 50/113 (44%)
PDI_a_PDI_a'_C 377..480 CDD:239293 61/102 (60%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 484..505 6/16 (38%)
Prevents secretion from ER. /evidence=ECO:0000250 502..505
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C167846791
Domainoid 1 1.000 135 1.000 Domainoid score I4962
eggNOG 1 0.900 - - E2759_KOG0190
Hieranoid 1 1.000 - -
Homologene 1 1.000 - - H68454
Inparanoid 1 1.050 426 1.000 Inparanoid score I1741
Isobase 1 0.950 - 0 Normalized mean entropy S1476
OMA 1 1.010 - - QHG53639
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 1 1.000 - - FOG0000292
OrthoInspector 1 1.000 - - oto93308
orthoMCL 1 0.900 - - OOG6_100478
Panther 1 1.100 - - LDO PTHR18929
Phylome 1 0.910 - -
RoundUp 1 1.030 - avgDist Average_Evolutionary_Distance R2224
SonicParanoid 1 1.000 - - X241
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 1 0.960 - -
1615.740

Return to query results.
Submit another query.