DRSC/TRiP Functional Genomics Resources

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Protein Alignment ERp60 and Pdia4

DIOPT Version :10

Sequence 1:NP_725084.2 Gene:ERp60 / 36270 FlyBaseID:FBgn0033663 Length:489 Species:Drosophila melanogaster
Sequence 2:NP_001355685.1 Gene:Pdia4 / 12304 MGIID:104864 Length:699 Species:Mus musculus


Alignment Length:497 Identity:191/497 - (38%)
Similarity:289/497 - (58%) Gaps:34/497 - (6%)


- Green bases have known domain annotations that are detailed below.


  Fly     3 WRLAGVLL-LGF--IAISSGAEQDVLELGDDDFATTLKQHETTL--VMFYAP------WCGHCKR 56
            |.:|.:|. |.|  .|:.......:|::..:|.:...:|....:  |:.::|      ||||||:
Mouse   201 WTVALLLFSLSFYQFAVLLSTHTGLLDVNANDKSLMFQQFSVPVGPVLSFSPRRHSKIWCGHCKK 265

  Fly    57 LKPEYAKAAEIVKDDDPPIKLAKVDCTEAGKETCSKYSVSGYPTLKIFRQDEVSQDYNGPREASG 121
            |.|||.|||:.:....|||.|||||.||. .:...::.|||||||||||:.. ..|||||||..|
Mouse   266 LAPEYEKAAKELSKRSPPIPLAKVDATEQ-TDLAKRFDVSGYPTLKIFRKGR-PFDYNGPREKYG 328

  Fly   122 IAKYMRAQVGPASKTVRTVAELKKFL-DTKDTTLFGYF-SDSDSKLAKIFLKF---ADKNREKYR 181
            |..||..|.||.||.:.|:.::::|| |..|..:.|.| .|.|    ..:|::   |:..||.|:
Mouse   329 IVDYMIEQSGPPSKEILTLKQVQEFLKDGDDVVIIGLFQGDGD----PAYLQYQDAANNLREDYK 389

  Fly   182 FGHSSEKEVLD-KQGETDKIVLIRAPHLSNKFES--SSIKFEGSSE-SDLSTFVKENFHGLVGHR 242
            |.|:...|:.. .:....|:||.......:|:|.  ..:..:||:| |.:..:|.::...|||||
Mouse   390 FHHTFSPEIAKFLKVSLGKLVLTHPEKFQSKYEPRFHVMDVQGSTEASAIKDYVVKHALPLVGHR 454

  Fly   243 --TQDSVKDFQNPLITAYYSVDYQKNPK-GTNYWRNRVLKVAKEFVGQINFAIASKDDFQHELNE 304
              :.|:.:..:.||:..|||||:..:.: .|.:|||:||:|||:| .:..||||.::|:..|:.:
Mouse   455 KTSNDAKRYSKRPLVVVYYSVDFSFDYRAATQFWRNKVLEVAKDF-PEYTFAIADEEDYATEVKD 518

  Fly   305 YGYDFVGDKPVVLARDEKNLKYALK-DEFSVENLQDFVEKLLANELEPYIKSEPIPESNDAPVKV 368
            .|....|:.......||...|:|:: :||..:.|::||......:|:|.|||:|:|::|..||||
Mouse   519 LGLSESGEDVNAAILDESGKKFAMEPEEFDSDTLREFVTAFKKGKLKPVIKSQPVPKNNKGPVKV 583

  Fly   369 AVAKNFDDLVINNGKDTLIEFYAPWCGHCKKLSPIYEELAEKLQ-DEDVAIVKMDATANDVP-PE 431
            .|.|.||.:|::..||.|||||||||||||:|.|||..|.:|.: .:|:.|.||||||||:. .:
Mouse   584 VVGKTFDAIVMDPKKDVLIEFYAPWCGHCKQLEPIYTSLGKKYKGQKDLVIAKMDATANDITNDQ 648

  Fly   432 FNVRGFPTLFWLPKDAKNKPVSYNGG-REVDDFLKYIAKEAT 472
            :.|.||||:::.|...|..|:.:.|| |:::...|:|.:.||
Mouse   649 YKVEGFPTIYFAPSGDKKNPIKFEGGNRDLEHLSKFIDEHAT 690

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
ERp60NP_725084.2 ER_PDI_fam 23..479 CDD:273457 185/474 (39%)
Pdia4NP_001355685.1 pdi_dom 63..164 CDD:273454
ER_PDI_fam 173..691 CDD:273457 191/497 (38%)
Blue background indicates that the domain is not in the aligned region.

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