DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment ERp60 and Pdia4

DIOPT Version :9

Sequence 1:	NP_725084.2	Gene:	ERp60 / 36270	FlyBaseID:	FBgn0033663	Length:	489	Species:	Drosophila melanogaster
Sequence 2:	NP_001355685.1	Gene:	Pdia4 / 12304	MGIID:	104864	Length:	699	Species:	Mus musculus

Alignment Length:	497	Identity:	191/497 - (38%)
Similarity:	289/497 - (58%)	Gaps:	34/497 - (6%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 WRLAGVLL-LGF--IAISSGAEQDVLELGDDDFATTLKQHETTL--VMFYAP------WCGHCKR 56
            |.:|.:|. |.|  .|:.......:|::..:|.:...:|....:  |:.::|      ||||||:
Mouse   201 WTVALLLFSLSFYQFAVLLSTHTGLLDVNANDKSLMFQQFSVPVGPVLSFSPRRHSKIWCGHCKK 265

  Fly    57 LKPEYAKAAEIVKDDDPPIKLAKVDCTEAGKETCSKYSVSGYPTLKIFRQDEVSQDYNGPREASG 121
            |.|||.|||:.:....|||.|||||.||. .:...::.|||||||||||:.. ..|||||||..|
Mouse   266 LAPEYEKAAKELSKRSPPIPLAKVDATEQ-TDLAKRFDVSGYPTLKIFRKGR-PFDYNGPREKYG 328

  Fly   122 IAKYMRAQVGPASKTVRTVAELKKFL-DTKDTTLFGYF-SDSDSKLAKIFLKF---ADKNREKYR 181
            |..||..|.||.||.:.|:.::::|| |..|..:.|.| .|.|    ..:|::   |:..||.|:
Mouse   329 IVDYMIEQSGPPSKEILTLKQVQEFLKDGDDVVIIGLFQGDGD----PAYLQYQDAANNLREDYK 389

  Fly   182 FGHSSEKEVLD-KQGETDKIVLIRAPHLSNKFES--SSIKFEGSSE-SDLSTFVKENFHGLVGHR 242
            |.|:...|:.. .:....|:||.......:|:|.  ..:..:||:| |.:..:|.::...|||||
Mouse   390 FHHTFSPEIAKFLKVSLGKLVLTHPEKFQSKYEPRFHVMDVQGSTEASAIKDYVVKHALPLVGHR 454

  Fly   243 --TQDSVKDFQNPLITAYYSVDYQKNPK-GTNYWRNRVLKVAKEFVGQINFAIASKDDFQHELNE 304
              :.|:.:..:.||:..|||||:..:.: .|.:|||:||:|||:| .:..||||.::|:..|:.:
Mouse   455 KTSNDAKRYSKRPLVVVYYSVDFSFDYRAATQFWRNKVLEVAKDF-PEYTFAIADEEDYATEVKD 518

  Fly   305 YGYDFVGDKPVVLARDEKNLKYALK-DEFSVENLQDFVEKLLANELEPYIKSEPIPESNDAPVKV 368
            .|....|:.......||...|:|:: :||..:.|::||......:|:|.|||:|:|::|..||||
Mouse   519 LGLSESGEDVNAAILDESGKKFAMEPEEFDSDTLREFVTAFKKGKLKPVIKSQPVPKNNKGPVKV 583

  Fly   369 AVAKNFDDLVINNGKDTLIEFYAPWCGHCKKLSPIYEELAEKLQ-DEDVAIVKMDATANDVP-PE 431
            .|.|.||.:|::..||.|||||||||||||:|.|||..|.:|.: .:|:.|.||||||||:. .:
Mouse   584 VVGKTFDAIVMDPKKDVLIEFYAPWCGHCKQLEPIYTSLGKKYKGQKDLVIAKMDATANDITNDQ 648

  Fly   432 FNVRGFPTLFWLPKDAKNKPVSYNGG-REVDDFLKYIAKEAT 472
            :.|.||||:::.|...|..|:.:.|| |:::...|:|.:.||
Mouse   649 YKVEGFPTIYFAPSGDKKNPIKFEGGNRDLEHLSKFIDEHAT 690

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ERp60	NP_725084.2	ER_PDI_fam	23..479	CDD:273457	185/474 (39%)
		PDI_a_PDIR	23..126	CDD:239295	48/110 (44%)
		PDI_b_ERp57	133..235	CDD:239367	29/110 (26%)
		PDI_b'_ERp72_ERp57	239..345	CDD:239371	39/109 (36%)
		PDI_a_PDI_a'_C	365..467	CDD:239293	52/104 (50%)
Pdia4	NP_001355685.1	pdi_dom	63..164	CDD:273454
Pdia4	NP_001355685.1	ER_PDI_fam	173..691	CDD:273457	191/497 (38%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0190
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG53639
OrthoDB	1	1.010	-	-		D222522at33208
OrthoFinder	1	1.000	-	-		FOG0000292
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2224
SonicParanoid	1	1.000	-	-		X241
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	7	6.860