Protein Alignment ERp60 and Txndc5

DIOPT Version :9

• Sequence 1: NP_725084.2
• Gene: ERp60 / 36270
• FlyBaseID: FBgn0033663
• Length: 489
• Species: Drosophila melanogaster
• Sequence 2: NP_663342.3
• Gene: Txndc5 / 105245
• MGIID: 2145316
• Length: 417
• Species: Mus musculus
• Alignment Length: 510
• Identity: 141/510 - (27%)
• Similarity: 216/510 - (42%)
• Gaps: 143/510 - (28%)

  Fly     5 LAG-------VLLLGF--------IAISSGAEQD--VLELGDDDFATTLKQHETTLVMFYAPWCG 52
            |||       :||||.        :...||.|||  ...|...|..|...|.....|||:|||||
Mouse    12 LAGLPALATLLLLLGARKGARAQEVEADSGVEQDPHAKHLYTADMFTHGIQSAAHFVMFFAPWCG 76

  Fly    53 HCKRLKPEYAKAAEIVKD-DDPPIKLAKVDCTEAGKETCSKYSVSGYPTLKIFRQDEVSQDYNGP 116
            ||:||:|.:....:.... :|..:.:|||||| |..:.||...|.||||||.|:..:.:..|.||
Mouse    77 HCQRLQPTWNDLGDKYNSMEDAKVYVAKVDCT-ADSDVCSAQGVRGYPTLKFFKPGQEAVKYQGP 140

  Fly   117 REASGIAKYMRAQVGPASKTVRTVAELKKFLDTKDTTLFGYFSDSDSKLAKIFLKFADKNREKYR 181
            |:...:..:|          ::|:.|
Mouse   141 RDFETLENWM----------LQTLNE--------------------------------------- 156

  Fly   182 FGHSSEKEVLDKQGETDKIVLIRAPHL-SNKFESSSIKFEGSSESDLSTFVKENFHGLVGHRTQD 245
                 |....:.:.|..     |||.| ...:|.|:..|| ...|..:.|:| .|....||
Mouse   157 -----EPATPEPEAEPP-----RAPELKQGLYELSANNFE-LHVSQGNHFIK-FFAPWCGH---- 205

  Fly   246 SVKDFQNPLITAYYSVDYQKNPKGTNYWRNRVLKVAKEFVGQINFAIASKDDFQHELNEYGYDFV 310
                      ....:..:::...|..:  :..:|:.|....| ::|:.|    :|::..|
Mouse   206 ----------CKALAPTWEQLALGLEH--SETVKIGKVDCTQ-HYAVCS----EHQVRGY----- 248

  Fly   311 GDKPVVL-ARDEKNL-KYALKDEFSVENLQDFVEKLLANELEPYIKSEPIPES---NDAPVKVA- 369
               |.:| .||.|.: :|  |.:..:|:|:|:|:..|..       ||..||:   ::|||..|
Mouse   249 ---PTLLWFRDGKKVDQY--KGKRDLESLRDYVQSQLQG-------SEAAPETVEPSEAPVMAAE 301

  Fly   370 -----------VAKNFDDLVINNGKDTLIEFYAPWCGHCKKLSPIYEELAEKLQD--EDVAIVKM 421
                       ..|:|:|.:...  .|.::||||||||||.|:|.:|||::|...  .||.|.::
Mouse   302 PTGDKGTVLALTEKSFEDTIAQG--ITFVKFYAPWCGHCKNLAPTWEELSKKEFPGLSDVTIAEV 364

  Fly   422 DATA-NDVPPEFNVRGFPTLFWLPKDAKNKPVSYNGGREVDDFLKYIAKEATTEL 475
            |.|| .:|..:::|||:|||  |......|...:||||::|....::.::|..||
Mouse   365 DCTAERNVCSKYSVRGYPTL--LLFRGGEKVGEHNGGRDLDSLHSFVLRQAKDEL 417

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ERp60	NP_725084.2	ER_PDI_fam	23..479	CDD:273457	130/477 (27%)
		PDI_a_PDIR	23..126	CDD:239295	40/105 (38%)
		PDI_b_ERp57	133..235	CDD:239367	15/102 (15%)
		PDI_b'_ERp72_ERp57	239..345	CDD:239371	21/107 (20%)
		PDI_a_PDI_a'_C	365..467	CDD:239293	43/116 (37%)
Txndc5	NP_663342.3	PDI_a_ERp46	47..150	CDD:239303	39/103 (38%)
		ER_PDI_fam	52..417	CDD:273457	126/468 (27%)
		PDI_a_ERp46	176..276	CDD:239303	28/132 (21%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	281..302		8/27 (30%)
		PDI_a_ERp46	308..409	CDD:239303	40/104 (38%)
		Prevents secretion from ER. /evidence=ECO:0000255|PROSITE-ProRule:PRU10138	414..417		0/2 (0%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910