DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ERp60 and PDIA6

DIOPT Version :9

Sequence 1:	NP_725084.2	Gene:	ERp60 / 36270	FlyBaseID:	FBgn0033663	Length:	489	Species:	Drosophila melanogaster
Sequence 2:	NP_001269633.1	Gene:	PDIA6 / 10130	HGNCID:	30168	Length:	492	Species:	Homo sapiens

Alignment Length:	462	Identity:	98/462 - (21%)
Similarity:	143/462 - (30%)	Gaps:	223/462 - (48%)

- Green bases have known domain annotations that are detailed below.

  Fly    13 FIAISS--GAEQDVLELGDDDFATTLKQHETT-LVMFYAPWCGHCKRLKPEYAKAAEIVKDDDPP 74
            |:|::.  .:..||:||...:|...:.|.::. ||.|||||||||:||.||:.|||..:||
Human    66 FLAVNGLYSSSDDVIELTPSNFNREVIQSDSLWLVEFYAPWCGHCQRLTPEWKKAATALKD---- 126

  Fly    75 IKLAKVDCTEAGKETC--SKYSVSGYPTLKIFRQDE-VSQDYNGPREASGIAKYMRAQVGPASKT 136
              :.||...:|.|...  .:|.|.|:||:|||..:: ..:||.|.|....|.
Human   127 --VVKVGAVDADKHHSLGGQYGVQGFPTIKIFGSNKNRPEDYQGGRTGEAIV------------- 176

  Fly   137 VRTVAELKKFLDTKDTTLFGYFSDSDSKLAKIFLKFADKNREKYRFGHSSEKEVLDKQGETDKIV 201
                                     |:.|:.:      :...|.|.|..|......|||.:|
Human   177 -------------------------DAALSAL------RQLVKDRLGGRSGGYSSGKQGRSD--- 207

  Fly   202 LIRAPHLSNKFESSSIKFEGSSESDLSTFVKENFHGLVGHRTQDSVKDFQNPLITAYYSVDYQKN 266
                               .||:.|:
Human   208 -------------------SSSKKDV--------------------------------------- 214

  Fly   267 PKGTNYWRNRVLKVAKEFVGQINFAIASKDDFQHELNEYGYDFVGDKPVVLARDEKNLKYALKDE 331
                                     |...||
Human   215 -------------------------IELTDD---------------------------------- 220

  Fly   332 FSVENLQDFVEKLLANELEPYIKSEPIPESNDAPVKVAVAKNFDDLVINNGKDTLIEFYAPWCGH 396
                                                     :||..|:::....::|||||||||
Human   221 -----------------------------------------SFDKNVLDSEDVWMVEFYAPWCGH 244

  Fly   397 CKKLSPIYEELAEKLQDEDVAIVKM---DATANDV-PPEFNVRGFPTLFWLPKDAKNKPVSYNGG 457
            ||.|.|.:...|.:::::....||:   |||.|.| ...:.:|||||:....|.  ..||.|:||
Human   245 CKNLEPEWAAAASEVKEQTKGKVKLAAVDATVNQVLASRYGIRGFPTIKIFQKG--ESPVDYDGG 307

  Fly   458 REVDDFL 464
            |...|.:
Human   308 RTRSDIV 314

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ERp60	NP_725084.2	ER_PDI_fam	23..479	CDD:273457	96/450 (21%)
		PDI_a_PDIR	23..126	CDD:239295	43/106 (41%)
		PDI_b_ERp57	133..235	CDD:239367	13/101 (13%)
		PDI_b'_ERp72_ERp57	239..345	CDD:239371	3/105 (3%)
		PDI_a_PDI_a'_C	365..467	CDD:239293	37/104 (36%)
PDIA6	NP_001269633.1	PDI_a_P5	78..180	CDD:239299	44/145 (30%)
		PDI_a_P5	213..318	CDD:239299	41/243 (17%)
		P5_C	327..456	CDD:239281
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910