Protein Alignment ERp60 and Txndc5

DIOPT Version :10

• Sequence 1: NP_725084.2
• Gene: ERp60 / 36270
• FlyBaseID: FBgn0033663
• Length: 489
• Species: Drosophila melanogaster
• Sequence 2: NP_001258259.1
• Gene: Txndc5 / 100362805
• RGDID: 2323973
• Length: 417
• Species: Rattus norvegicus
• Alignment Length: 513
• Identity: 142/513 - (27%)
• Similarity: 216/513 - (42%)
• Gaps: 149/513 - (29%)

  Fly     5 LAG-------VLLLGF--------IAISSGAEQD--VLELGDDDFATTLKQHETTLVMFYAPWCG 52
            |||       :||||.        :...||.|||  ...|...|..|...|.....|||:|||||
  Rat    12 LAGLPALATLLLLLGARKGARAQEVEADSGVEQDPHAKHLYTADMFTHGIQSAAHFVMFFAPWCG 76

  Fly    53 HCKRLKPEYAKAAEIVKD-DDPPIKLAKVDCTEAGKETCSKYSVSGYPTLKIFRQDEVSQDYNGP 116
            ||:||:|.:....:.... :|..:.:|||||| |..:.||...|.||||||.|:..:.:..|.||
  Rat    77 HCQRLQPTWNDLGDKYNSMEDAKVYVAKVDCT-ANSDVCSAQGVRGYPTLKFFKPGQEAVKYQGP 140

  Fly   117 REASGIAKYMRAQVGPASKTVRTVAELKKFLDTKDTTLFGYFSDSDSKLAKIFLKFADKNREKYR 181
            |:...:..:|          ::|:.|
  Rat   141 RDFETLENWM----------LQTLNE--------------------------------------- 156

  Fly   182 FGHSSEKEVLDKQGETDKIVLIRAPHL-SNKFESSSIKFEGSSESDLSTFVKENFHGLVGHRTQD 245
                 |....:.:.|..     |||.| ...:|.|:..|| ...|..:.|:| .|....||
  Rat   157 -----EPATPEPEAEPP-----RAPELKQGLYELSANNFE-LHVSQGNHFIK-FFAPWCGH---- 205

  Fly   246 SVKDFQNPLITAYYSVDYQKNPKGTNYWRNRVLKVAKEFVGQINFAIASKDDFQHELNEYGYDFV 310
                      ....:..:::...|..:  :..:|:.|....| ::|:.|    :|::..|
  Rat   206 ----------CKALAPTWEQLALGLEH--SETVKIGKVDCTQ-HYAVCS----EHQVRGY----- 248

  Fly   311 GDKPVVL-ARDEKNL-KYALKDEFSVENLQDFVEKLLANELEPYIKSEPIPES---NDAPVKVA- 369
               |.:| .||.|.: :|  |.:..:|:|:|:|:..|..       ||..||:   ::|||..|
  Rat   249 ---PTLLWFRDGKKVDQY--KGKRDLESLRDYVQSQLQG-------SEAAPETVEPSEAPVLAAE 301

  Fly   370 -----------VAKNFDDLVINNGKDTLIEFYAPWCGHCKKLSPIYEELAEKLQDE-----DVAI 418
                       ..|:|:|.:...  .|.::||||||||||.|:|.:|||::|   |     ||.|
  Rat   302 PPGDKGTVLALTEKSFEDTIAQG--ITFVKFYAPWCGHCKNLAPTWEELSKK---EFPGLADVTI 361

  Fly   419 VKMDATA-NDVPPEFNVRGFPTLFWLPKDAKNKPVSYNGGREVDDFLKYIAKEATTEL 475
            .::|.|| ..|..:::|||:|||  |......|...:||||::|....::.::|..||
  Rat   362 AEVDCTAERGVCSKYSVRGYPTL--LLFRGGEKVGEHNGGRDLDSLHSFVLRQAKDEL 417

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ERp60	NP_725084.2	ER_PDI_fam	23..479	CDD:273457	131/480 (27%)
Txndc5	NP_001258259.1	PDI_a_ERp46	47..150	CDD:239303	39/103 (38%)
		PDI_a_ERp46	176..276	CDD:239303	28/132 (21%)
		PDI_a_ERp46	308..409	CDD:239303	41/107 (38%)