DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG13185 and Hecw1

DIOPT Version :9

Sequence 1:	NP_001097279.2	Gene:	CG13185 / 36268	FlyBaseID:	FBgn0033661	Length:	5526	Species:	Drosophila melanogaster
Sequence 2:	XP_006516872.1	Gene:	Hecw1 / 94253	MGIID:	2444115	Length:	1605	Species:	Mus musculus

Alignment Length:	1162	Identity:	218/1162 - (18%)
Similarity:	382/1162 - (32%)	Gaps:	386/1162 - (33%)

- Green bases have known domain annotations that are detailed below.

  Fly  4486 SKEALQEQHLKKCLTGELTSDWQQLSLPR-----------------------------------V 4515
            |:|..|.|..::.::..| ||:|.:.|.:                                   :
Mouse   193 SEETAQSQGSRRLISFSL-SDFQAMGLKKGMFFNPDPYLKISIQPGKHSIFPALPHHGQERRSTI 256

  Fly  4516 LGKLSNVLLVLKHSHF----------EGKDKLL----CVRRAIGLL--PV---LEQYQL---LAD 4558
            :|...|.:...:|..|          |.|||..    .::|.:|.|  ||   ||::.:   :..
Mouse   257 IGNTVNPIWQAEHFSFVSLPTDVLEIEVKDKFAKSRPIIKRFLGKLSMPVQRLLERHAIGDRVVS 321

  Fly  4559 YLLLQQLATHKVSAKM---LSIVLTVFVEIGSKGFCVPPDLMQDEEGQSKQESKNGEGFGLEDGT 4620
            |.|.::|.|..||.::   ..|..::..:.........|     |.....|:|......|..:|.
Mouse   322 YTLGRRLPTDHVSGQLQFRFEITSSIHADDEEISLSAEP-----ESSAETQDSIMNSMVGNSNGE 381

  Fly  4621 GENDASDKIESEDQLDDAKRPEDRKDEGDKQEPDCKEEKGIEMSDDFDAKMQDVEKPEEDDSGES 4685
            ...||::..:      ||| ||. ..||:          |:..|::   :.|:...|.|:.:|..
Mouse   382 PSGDATEFCK------DAK-PES-PSEGN----------GVNSSEN---QNQEHAGPVEEAAGAM 425

  Fly  4686 EEEEDLN-----KEMGETEEGAEKLDDQIWGDDEEEK---PEEEQEPD--MNEEDQGKGSKDEKD 4740
            |..:..|     :|.||.:: .|:.|.|.....||..   |.:|..|.  :.||:...|||.|::
Mouse   426 EARDGSNVSEAPEEPGELQD-PEQHDTQPTLSAEEVAEGLPLDEDSPSSLLPEENTALGSKVEEE 489

  Fly  4741 AHNDLDTKNDAAKED---GKDEHEKDGLDATNEPSGE----------DKRKEQAKDIDDMK---- 4788
            .    ..:|.|.:|:   ||||.|::. |.:....||          .|.:..:..:.:::
Mouse   490 T----VPENGAREEEMQKGKDEEEEEE-DVSTLEQGEPGLELRVSVRKKSRPCSLPVSELETVIA 549

  Fly  4789 ----DPEMDEEQTNAMHNELEEPPEPEEMDLGDMNNVDEGHDDQDEQPTDENPFDIDAMKENMQP 4849
                |.|........:|..|...|..:.      .:..|..|..:|:.|.:...:.|.:.|....
Mouse   550 SACGDAETPRTHYIRIHTLLHSMPSAQR------GSTTEEEDGLEEESTLKESSEKDGLSEVDTI 608

  Fly  4850 AEEPEADGDDEHDANEEGDPQSDGSD---SEEDEAGTEAKPAEEDHGEGEEATPEDEKDEAETQK 4911
            |.:|::..|.|          |||:.   :..|.:|.......:..|.|::
Mouse   609 AADPQSMEDGE----------SDGATLCMAPSDCSGGHFSSLSKGIGAGQD-------------- 649

  Fly  4912 RGELEDEDDSKPEDSPEDSKEEKEEKREE---KPEEHS--------------------------- 4946
             ||......|:.:.||:...:...|..:.   .|..:|
Mouse   650 -GEAHPSTGSESDSSPQQGADHSCEGCDASCCSPSCYSTSCYSSSCYSSSCYSSSCYNGNNRFAS 713

  Fly  4947 ----QSKDKASKEENV---QSMPETDQSSSADQVQQPQDPDIKQDQKLDEQETGEEKDGVGQAEN 5004
                .|.|.|...|:.   ....|.:::|:.:.|     ||..|..:||.:.|    :|.|..::
Mouse   714 HTRFSSVDSAKISESTVFSSQEDEEEENSAFESV-----PDSVQSPELDPEST----NGAGPWQD 769

  Fly  5005 D-ADDGGHQGVAETQETVSQEDRKNERQTQ--EKRKQGRTNEERSLGEAEQNKLKQLKTIDQLKD 5066
            : |..||:..                |.|:  |....|.:|..    |.|...|...:.|.||
Mouse   770 ELAAPGGNAA----------------RSTEGLESPMAGPSNRR----EGECPILHNSQPISQL-- 812

  Fly  5067 SKESDDAEQEKPEPMDQTEAEEYQHVKEPKNSDKTTLDNATEEQSKKIQHQEDEPPN-EEEIEA- 5129
                         |..:.|...|..:.||.                        ||| |..|::
Mouse   813 -------------PSLRPEHHHYPTIDEPL------------------------PPNWEARIDSH 840

  Fly  5130 ------ENVDELMEAEEPAVDPEDDAELEQLGAEKTEQKSDKPSKTEKSKEQLETPEGMEIEGEV 5188
                  ::::.....:.|::.|..|..:......:.||.:.:....::
Mouse   841 GRVFYVDHINRTTTWQRPSMAPTPDGMIRSGSVHQMEQLNRRYQNIQR----------------- 888

  Fly  5189 VLTMTVPRSSETTAHSNSEILLD------KSSHAEDLSSAEQIELRQQ--------------YQK 5233
              ||...|:.|.:.:.|||.:.|      ..|.:|..||...::||::              .|.
Mouse   889 --TMATERAEEDSGNQNSEQIPDGGGGGGGGSDSEAESSQSSLDLRREGSLSPVNSQKVTLLLQS 951

  Fly  5234 QLTTFRVAQPE-----HEDYETWQGISNRMTQNARELCEQLRLILEPTKCTRLKGDYRTGRRINM 5293
            ....| :..||     |.:|..::..::       ..|.: .:||      :::.|.|...|...
Mouse   952 PAVKF-ITNPEFFTVLHANYSAYRVFTS-------STCLK-HMIL------KVRRDARNFERYQH 1001

  Fly  5294 KKIIPYIASQFRKDKIWLRRTKPAQRDYKITIAIDDSKS--MHHNNSKT------LTLEAISLVS 5350
            .:.:....:.|...::.|.|....:.|::       .||  :.||:..|      :.|:...|.:
Mouse  1002 NRDLVNFINMFADTRLELPRGWEIKTDHQ-------GKSFFVDHNSRATTFIDPRIPLQNGRLPN 1059

  Fly  5351 QALTLLESGRLSIVSFGEAPQIILNHTEQF---DGPRLVNALNFAQDKTKIAGLLN-----FIRT 5407
            .........||...|.|||.::..|.....   .|..|:.|:........:....|     |:|.
Mouse  1060 HLTHRQHLQRLRSYSAGEASEVSRNRGASLLARPGHSLIAAIRSQHQHESLPLAYNDKIVAFLRQ 1124

  Fly  5408 ANAEES---------------------GTGGDNGLFE-----NLLLILSDGRNIFSE 5438
            .|..|.                     .|.|::||.:     :|:::||    :|.|
Mouse  1125 PNIFEMLQERQPSLARNHTLREKIHYIRTEGNHGLDKLSCDADLVILLS----LFEE 1177

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG13185	NP_001097279.2	MDN1	298..5521	CDD:227596	218/1162 (19%)
		P-loop_NTPase	315..505	CDD:304359
		P-loop_NTPase	<887..972	CDD:304359
		P-loop_NTPase	1147..1283	CDD:304359
		P-loop_NTPase	1454..1603	CDD:304359
		P-loop_NTPase	1795..1946	CDD:304359
		P-loop_NTPase	<2335..>2378	CDD:304359
		Prothymosin	4843..4920	CDD:281265	14/79 (18%)
		PHA03151	4856..5060	CDD:177546	43/246 (17%)
		MttA_Hcf106	<5046..5166	CDD:294511	21/127 (17%)
		vWA_midasin	5261..5526	CDD:238737	41/220 (19%)
Hecw1	XP_006516872.1	HECW_N	66..185	CDD:374632
		C2_NEDL1-like	206..342	CDD:176073	26/136 (19%)
		Neuromodulin	378..500	CDD:369001	37/147 (25%)
		WW	829..858	CDD:366073	5/52 (10%)
		HECW1_helix	947..1013	CDD:375862	12/80 (15%)
		WW	1019..1050	CDD:197736	8/37 (22%)
		HECTc	1249..1603	CDD:238033
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910