DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG13185 and NSR1

DIOPT Version :9

Sequence 1:	NP_001097279.2	Gene:	CG13185 / 36268	FlyBaseID:	FBgn0033661	Length:	5526	Species:	Drosophila melanogaster
Sequence 2:	NP_011675.1	Gene:	NSR1 / 853064	SGDID:	S000003391	Length:	414	Species:	Saccharomyces cerevisiae

Alignment Length:	405	Identity:	81/405 - (20%)
Similarity:	151/405 - (37%)	Gaps:	92/405 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly  4836 NPFDIDAMKENMQPAEEPEADGDDEHDANEEGDPQSDGSDSEEDEAGTEAKPAEEDHGEGEEATP 4900
            |..::.|.|:..:...:..:....|..::.....:|:.....|.|:.:.:..::   .|...::.
Yeast    10 NKKEVKASKQAKEEKAKAVSSSSSESSSSSSSSSESESESESESESSSSSSSSD---SESSSSSS 71

  Fly  4901 EDEKDEAETQKRGELEDEDDSKPEDSPEDSKEEKEEKREEKPEEHSQSKDKASKEENVQSMPETD 4965
            .|.:.||||:|    |:..||....|...|.||:||::||..:|.|:....:....:..|..|::
Yeast    72 SDSESEAETKK----EESKDSSSSSSDSSSDEEEEEEKEETKKEESKESSSSDSSSSSSSDSESE 132

  Fly  4966 QSSSADQVQQPQDPDIKQDQK-LDEQETGEEKDG-----VGQAENDADD----------GGHQGV 5014
            :..|.|:.::.:|.:.::|:: .::::..||.:.     ||:.....||          ||..|.
Yeast   133 KEESNDKKRKSEDAEEEEDEESSNKKQKNEETEEPATIFVGRLSWSIDDEWLKKEFEHIGGVIGA 197

  Fly  5015 AETQETVSQEDRKNERQTQEKRKQGRTNEERSLGEAEQNKLKQLKTIDQLKDSKESDDAEQEKPE 5079
            ....          ||.|...|..|..:.|        ||....|.|.::: .||.|.
Yeast   198 RVIY----------ERGTDRSRGYGYVDFE--------NKSYAEKAIQEMQ-GKEIDG------- 236

  Fly  5080 PMDQTEAEEYQHVKEPKNSDKTTLDNA-TEEQSKKIQHQEDEPPNEEEIEAENVDELMEAEEPAV 5143
                          .|.|.|.:|...| ..:::||......||  .:.:...|:         :.
Yeast   237 --------------RPINCDMSTSKPAGNNDRAKKFGDTPSEP--SDTLFLGNL---------SF 276

  Fly  5144 DPEDDAELEQLGAE--------KTEQKSDKP--------SKTEKSKEQLETPEGMEIEGEVV-LT 5191
            :.:.||..|.....        .|..::::|        |..|.:|:.|:..:|..|:...| |.
Yeast   277 NADRDAIFELFAKHGEVVSVRIPTHPETEQPKGFGYVQFSNMEDAKKALDALQGEYIDNRPVRLD 341

  Fly  5192 MTVPRSSETTAHSNS 5206
            .:.||.:.......|
Yeast   342 FSSPRPNNDGGRGGS 356

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG13185	NP_001097279.2	MDN1	298..5521	CDD:227596	81/405 (20%)
		P-loop_NTPase	315..505	CDD:304359
		P-loop_NTPase	<887..972	CDD:304359
		P-loop_NTPase	1147..1283	CDD:304359
		P-loop_NTPase	1454..1603	CDD:304359
		P-loop_NTPase	1795..1946	CDD:304359
		P-loop_NTPase	<2335..>2378	CDD:304359
		Prothymosin	4843..4920	CDD:281265	13/76 (17%)
		PHA03151	4856..5060	CDD:177546	47/219 (21%)
		MttA_Hcf106	<5046..5166	CDD:294511	21/128 (16%)
		vWA_midasin	5261..5526	CDD:238737
NSR1	NP_011675.1	RRM1_gar2	169..244	CDD:409881	23/114 (20%)
NSR1	NP_011675.1	RRM2_gar2	269..341	CDD:409882	13/80 (16%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910