|
Fly 33 QKFIKKQKYVPQD-VERLF-----RSLSEQLPLPAYTVPIAASFEEQLLL----LLSMALRWDSA 87
|:.|......|.| :|..| .|.||.|...|.|:..:.|....:.| .|.:..||...
Yeast 15 QRLILFNSAFPSDAIEAPFHFSNKESTSENLDNLAGTILHSRSITGHVFLYKHIFLEIVARWIKD 79
Fly 88 SQRFHTYQLECVALSKLMNFSLDAQRFAKSYFHDKPAPFEKQQSNGSLPSKKSKNGNHAADNLDD 152
|:: ..|.|....|:.::.....|....:.|...:...|.....| ||.:. |
Yeast 80 SKK-KDYVLVIEKLASIITIFPVAMPLIEDYLDKENDHFITILQN---PSTQK-----------D 129
Fly 153 LELIKCCFQLLKSDTPYFRELWDWSSFIATYTHNSSSPKTQLYCNYI--------VAMLTNMSAP 209
.:: |::|.: |:|.|: ||. :::..:| |.:||.....
Yeast 130 SDM----FKILLA---YYRLLY----------HNK-----EVFARFIQPDILYQLVDLLTKEQEN 172
Fly 210 QL-----------------NSLNEKIST--KTR------LEFDQEREQAW---NTARNTLCS--- 243
|: .:||:.:.| |:| .|.|...:.:: |.|:. |:
Yeast 173 QVVIFLALKVLSLYLDMGEKTLNDMLDTYIKSRDSLLGHFEGDSGIDYSFLELNEAKR--CANFS 235
Fly 244 --------YTPDASDQLLNLHLHGINKSVTNIEGVLLP---TFNEENLEFYASTDGCYDRIVKVD 297
:|.:.......:....::..|.:|.||::| |.::: .||..| .|...
Yeast 236 KLPSVPECFTIEKKSSYFIIEPQDLSTKVASICGVIVPKVHTIHDK--VFYPLT------FVPTH 292
Fly 298 STVVNLRSIALGVAAAKPICLSGPVGCGKTTLIEYLARKTGRICPKPNEIESREKALKKAEEEEQ 362
.||.:||.:...:..:.||.|.|..|.|||.||..|::..| |
Yeast 293 KTVSSLRQLGRKIQNSTPIMLIGKAGSGKTFLINELSKYMG--C--------------------- 334
Fly 363 LLTPKKKAKTTGSKRKLEEVPLEELLDLGETTKKSGFLRIQLGDQTDSKMLLGQYRCTDVPGEFV 427
....::|.||:|||:|:|:|.|...|.||.|.
Yeast 335 ---------------------------------HDSIVKIHLGEQTDAKLLIGTYTSGDKPGTFE 366
Fly 428 WLPGVLTQAVMHGYWLLLEDLDAATQDTYTILSSLLERQCLSVPGFRDSVKIEPGFQLFVTVRTN 492
|..|||..||..|.|:|:||:|.|..|..:||.||||::.|::|...::||...||||..|||.|
Yeast 367 WRAGVLATAVKEGRWVLIEDIDKAPTDVLSILLSLLEKRELTIPSRGETVKAANGFQLISTVRIN 431
Fly 493 KSASNSSQKSLYSLLDKYLYTINILPL---SRNELCKMVSINYPKLSTVANRIVD---------- 544
:.....|...:|:|....:...|::.| |..:|..:::..:|.|:.:..:::|
Yeast 432 EDHQKDSSNKIYNLNMIGMRIWNVIELEEPSEEDLTHILAQKFPILTNLIPKLIDSYKNVKSIYM 496
Fly 545 --VFLTFSSGNHTSADNLRQQESGDKADNTEQYVALPFEQVPLTSSPNSGRLVSTRDLVKLCHR- 606
.|::.:.|.|| |:||.|||:|||.|
Yeast 497 NTKFISLNKGAHT-------------------------------------RVVSVRDLIKLCERL 524
Fly 607 ---------SNPQFSVTSSECAY-FVFQNAVDVFCSYLPQSKEKVTLITSIGAKLGIIRSRCEHF 661
:.|...:.|| .| .:|..|.|.|...:.:.|....:|.:||..|.|..||...|
Yeast 525 DILFKNNGINKPDQLIQSS--VYDSIFSEAADCFAGAIGEFKALEPIIQAIGESLDIASSRISLF 587
Fly 662 ANEYKPDVEFGLEHIKIGRASLLAKSDLNNSENEDISEQDLKRQKLSQQTRRAIGKVSNKRTTFS 726
..::.|.:|...:.||||||.|| ::||: |.|.|...|.|:
Yeast 588 LTQHVPTLENLDDSIKIGRAVLL-------------------KEKLN------IQKKSMNSTLFA 627
Fly 727 FTRLASCILERIAVCVTHSEPVLLVGETGVGKTSSVQYLAERTEHKLVVVNMNNQSDVSDLVGGF 791
||..:..::|:|:||:..:||||||||||.|||:.||.||:....||.|:|::.|::..||:||:
Yeast 628 FTNHSLRLMEQISVCIQMTEPVLLVGETGTGKTTVVQQLAKMLAKKLTVINVSQQTETGDLLGGY 692
Fly 792 KPVELNYVLAPLRNEFEYLLCETFNQEKNLQFLRLFATHYNSGRHAVIIR----------TMINI 846
|||....|..|::..||.|...||:.:||.:|.::....:|..:...::: :::.|
Yeast 693 KPVNSKTVAVPIQENFETLFNATFSLKKNEKFHKMLHRCFNKNQWKNVVKLWNEAYKMAQSILKI 757
Fly 847 CLQVAKNPELKANK----------LLPRWQTLREKLQKLQMQLDKSINISFA--FIPGSLVNCIS 899
.....:|...|..| ||.:|....:.::|.:.| ..||..||. |:.||||..|.
Yeast 758 TNTENENENAKKKKRRLNTHEKKLLLDKWADFNDSVKKFEAQ-SSSIENSFVFNFVEGSLVKTIR 821
Fly 900 NGDWVLLDEINLASAETLECLSTIL-EPEG-SVVLLERGDFTPVKRHPDFRIFACMNPNTDIGKK 962
.|:|:||||:|||:|:|||.:|.:| ||:. |::|.|:||..|:|.||||||||||||.||:||:
Yeast 822 AGEWLLLDEVNLATADTLESISDLLTEPDSRSILLSEKGDAEPIKAHPDFRIFACMNPATDVGKR 886
Fly 963 DLPVGIRNRFTEFFVDELTTD-ADLSLLVSDYLANTGIQRKSVHN-IVQLYKSLRKLSELQ-LND 1024
|||:|||:||||.:|.....| .||..::..|:....:..:.|.| |.:||...:|||:.. :.|
Yeast 887 DLPMGIRSRFTEIYVHSPERDITDLLSIIDKYIGKYSVSDEWVGNDIAELYLEAKKLSDNNTIVD 951
Fly 1025 GLGNRPVYSLRTLCRSLRICAR--NLCGSIERNLYESFCLSFLTQLDPNSHHVVLLLIQN---AL 1084
|...:|.:|:|||.|:|..... ::.| :.|:||:.||:||||.||..|..::..:|:. ..
Yeast 952 GSNQKPHFSIRTLTRTLLYVTDIIHIYG-LRRSLYDGFCMSFLTLLDQKSEAILKPVIEKFTLGR 1015
Fly 1085 LSNVKAILSKQLPQLGENYLDFEGYWIQPGNLEPQPCTHYILTESVKKNLKDLARIISIGKLPIL 1149
|.|||:|:|:..|..|.:|:.|:.||::.|....|...|||:|..|:||:.:|.|..|..:.|:|
Yeast 1016 LKNVKSIMSQTPPSPGPDYVQFKHYWMKKGPNTIQEQAHYIITPFVEKNMMNLVRATSGKRFPVL 1080
Fly 1150 LQGPTSAGKTSLIDYVARRSGNRCLRINNHEHTDLQEYIGTYAADLDGKLTFREGVLVQAMRHGF 1214
:|||||:||||:|.|:|..:|::.:|||||||||||||:|||..|..|||:|:|||||:|:|.|:
Yeast 1081 IQGPTSSGKTSMIKYLADITGHKFVRINNHEHTDLQEYLGTYVTDDTGKLSFKEGVLVEALRKGY 1145
Fly 1215 WIILDELNLASTDILEALNRVLDDNRELYIAETQTLVKAHPNFMLFATQNPPGLYGGRKTLSRAF 1279
||:|||||||.||:||||||:|||||||:|.|||.:|..||:|:|||||||||:|||||.|||||
Yeast 1146 WIVLDELNLAPTDVLEALNRLLDDNRELFIPETQEVVHPHPDFLLFATQNPPGIYGGRKILSRAF 1210
Fly 1280 KNRFIELHFADIPREELETILEKRCFIPPTYARKMVQCMTQLQQHRKNT----SKQVF-TLRDLF 1339
:|||:||||.|||::|||.||.:||.|.|:||:|:|:...||...|..: .|..| ||||||
Yeast 1211 RNRFLELHFDDIPQDELEIILRERCQIAPSYAKKIVEVYRQLSIERSASRLFEQKNSFATLRDLF 1275
Fly 1340 RWGNRYTHADKSLHDDNRYDWNQHLVEEGYLVLSSKVRSQEEHELIEKTLFANFRKKLDLQTLFD 1404
|| :|.|...| :.|...||::|:.:.|:.:|...::|||....:.|||:...:
Yeast 1276 RW---------ALRDAVGY---EQLAASGYMLLAERCRTPQEKVTVKKTLEKVMKVKLDMDQYY- 1327
Fly 1405 IQTDRESSSMVSRKILDAIRNFKLRDDIVWTRNMTRMAVVTAKALEFDEPVLLVGPTGCGKTTVC 1469
:.:..|.|:|| ..:.||:.|.|::|:.:..|:..|||||||.|||||||:|
Yeast 1328 --------ASLEDKSLEAI------GSVTWTKGMRRLSVLVSSCLKNKEPVLLVGETGCGKTTIC 1378
Fly 1470 QLLASIADVQLRILNCHMHTEGADFLGGLRPCRGKESTQ-------------------------- 1508
||||.....:|..||.|.:||..|.||..||.|.:...|
Yeast 1379 QLLAQFMGRELITLNAHQNTETGDILGAQRPVRNRSEIQYKLIKSLKTALNIANDQDVDLKELLQ 1443
Fly 1509 ---------------------------LFEWADGPLIYAMQEGSYFMADEISLAEDSVLERLNCI 1546
||||:|||||.||:.|::|:.||||||:||||||||.:
Yeast 1444 LYSKSDNKNIAEDVQLEIQKLRDSLNVLFEWSDGPLIQAMRTGNFFLLDEISLADDSVLERLNSV 1508
Fly 1547 LEPERTVLLAEKGGISELDASPDFVVQAKSGFQFLATMNPGGDFGKKELSPALRNRFTEVWCLPS 1611
|||||::||||:| |.|.:|.|...|||.||||||||:|||||||||||||||:| :||
Yeast 1509 LEPERSLLLAEQG-------SSDSLVTASENFQFFATMNPGGDYGKKELSPALRNRFTEIW-VPS 1565
Fly 1612 DNKEDLIEIAYNCMRRQKEHENQAINTHKVAEYLVDVVLHIRDTNDKF------------KFSVR 1664
.||..:: |..::: ::.|.|.|:...|...::.| ..|:|
Yeast 1566 --MEDFNDV------------NMIVSS-RLLEDLKDLANPIVKFSEWFGKKLGGGNATSGVISLR 1615
Fly 1665 DILAWANYM------VSNAKLSFAEQAIFGLETIFLDAL----EMLPHESQEQVELLKSNIVKQA 1719
|||||..:: :.|...:. |.|...:|:||| .....|::..::.|::..:.|.
Yeast 1616 DILAWVEFINKVFPKIQNKSTAL----IQGASMVFIDALGTNNTAYLAENENDLKSLRTECIIQL 1676
Fly 1720 IKQA--SLILQEKFTLEELSEKRGTEVELNECRFGIRPFFIDVNQERLTSAKEDFLFDAPTTKQN 1782
:|.. .|.||: .|.:|...|:.||....|.| |.|.| :....|...||||..|
Yeast 1677 LKLCGDDLELQQ----IETNEIIVTQDELQVGMFKI-PRFPD-------AQSSSFNLTAPTTASN 1729
Fly 1783 LFRLLSALSLQKPVLLEGPPGVGKTSIVESIGSAIGYQIVRINLCEHTDLADLFGTDLPAEDNLL 1847
|.|::.|:.:.||:||||.|||||||::.::.:..|.::.||||.|.|||.||||.|.|.|
Yeast 1730 LVRVVRAMQVHKPILLEGSPGVGKTSLITALANITGNKLTRINLSEQTDLVDLFGADAPGE---- 1790
Fly 1848 ESNTAATERQIRS--FVWRDGPLLAALKAKNTWILLDELNLAPQSVLEGLNAVLDHRGEVYIPEL 1910
|| |:|.|.|.|.|:| |..|:||||:|||.|||||||||.||||||.|||||
Yeast 1791 -----------RSGEFLWHDAPFLRAMK-KGEWVLLDEMNLASQSVLEGLNACLDHRGEAYIPEL 1843
Fly 1911 NKSFHLAGSTRIFACQNPLKQGGGRKGLPQSFLNRFTKVYLRKLSTEDLLHVVTEKYGKYFDQLN 1975
:.||....:..:||.|||..|||||||||:||:|||:.|::..|:::|||.:....|
Yeast 1844 DISFSCHPNFLVFAAQNPQYQGGGRKGLPKSFVNRFSVVFIDMLTSDDLLLIAKHLY-------- 1900
Fly 1976 AYFLELLDQKAEGNLFEIYSGKESSCKSDSFDLGARLVRFSEQLDRGVASME-FGYKGGPYEFNL 2039
.|...|:.|::::....|:..|...: :|..|.|:||||
Yeast 1901 --------------------------PSIEPDIIAKMIKLMSTLEDQVCKRKLWGNSGSPWEFNL 1939
Fly 2040 RDILRWCDLLHNPQTGYILGASPSSFQAAFKDFLLTLYERMQLVYYQRMRCDQDKS----YIRNV 2100
||.|||..||:. |.:......| || :.::..||.|...||: .|.::
Yeast 1940 RDTLRWLKLLNQ----YSICEDVDVF-----DF-------VDIIVKQRFRTISDKNKAQLLIEDI 1988
Fly 2101 F------STVFLCDAEYLNQVSNDVALYWTADKVYLNDVVLSRKQADVLDLVNRQEQSPLL---- 2155
| ...|....:|: |::|:|||. |...:.|:.
Yeast 1989 FGKFSTKENFFKLTEDYV-QINNEVALR------------------------NPHYRYPITQNLF 2028
Fly 2156 -LDSQRQQLKQIIETVHMEKPLLLCGSTDSGKTKLIDALC-VLSNRL----CNTDIIDDSVTGSF 2214
|:......:.:::.::...||:|.|.::||||:.|..|. :|..|: .|:||....:.|.:
Yeast 2029 PLECNVAVYESVLKAINNNWPLVLVGPSNSGKTETIRFLASILGPRVDVFSMNSDIDSMDILGGY 2093
Fly 2215 QQIDLNRHLEIIYKKVETLVFSCVQRAFVLHTQSEFVEQLWNNWSMYNKLAKVTTEAQQHSVLDE 2279
:|:||.|.:..|.:::..:|...: ||..||:...| ::::.
Yeast 2094 EQVDLTRQISYITEELTNIVREII--------------------SMNMKLSPNAT-----AIMEG 2133
Fly 2280 LKLFSERLGSLGKIIEVLEATPQNCQ------------------VRALQQLAEIKSQLLLLQTYI 2326
|.|....|.:: .||:..| ::.:....|..::::..:..:
Yeast 2134 LNLLKYLLNNI--------VTPEKFQDFRNRFNRFFSHLEGHPLLKTMSMNIEKMTEIITKEASV 2190
Fly 2327 KTADSLNTGGSFEWVDSQIVTSLKCGQYILLEHVNLCSSAVLDRLNPVFEPNGSLLIAEKGISAQ 2391
| |||.|..:|.:::.|.:::|::.||||.:||||||.:.|.:|||||.| .|.:
Yeast 2191 K----------FEWFDGMLVKAVEKGHWLILDNANLCSPSVLDRLNSLLEIDGSLLINE--CSQE 2243
Fly 2392 DSAEVVYK-STNFRAFLTVDPKNGELSRAMRNRCVELSLSRDTYSVDDLRAFVHEQGVREMEAID 2455
|....|.| ..|||.|||:|||.||||||||||.||: .:|:|.
Yeast 2244 DGQPRVLKPHPNFRLFLTMDPKYGELSRAMRNRGVEI-------YIDELH--------------- 2286
Fly 2456 CILRVHKGLSQLTEFNNYSISHLTQFAFLSAAYRRIGYELKRAIYVAAME--VYVYSANTDLMGY 2518
|:.|.|:..: :|:||...|...::: :.....|...|..
Yeast 2287 ---------SRSTAFDRLT----------------LGFELGENIDFVSIDDGIKKIKLNEPDMSI 2326
Fly 2519 GLSYYQNKL--REVVLAQT---------EVFEE--VAVIQEDFLSDVILNSGNLNSLTLIKRQAV 2570
.|.:|.... |..:.||. |..|| .|||....|.:|...:.|:.:.|
Yeast 2327 PLKHYVPSYLSRPCIFAQVHDILLLSDEEPIEESLAAVIPISHLGEVGKWANNVLNCT------- 2384
Fly 2571 ALKVLLDGYTEGKIPQKLLASLFHEMEKLKLDQRNPQKLIRHFLYMLYESSAIGDLE-LRHLYLQ 2634
.|:|.||.::|.. |:..|.: :|.|| :.:|| :
Yeast 2385 -------EYSEKKIAERLYV----------------------FITFLTD---MGVLEKINNLY-K 2416
Fly 2635 PWLSKDTAFQELSQNLYNCLQKRSNTDTGTLANLPWNRKLIPRLRDYSTAESNSE---------- 2689
| .:..||: :..|:: |:...:| .:|..|..::|.:..||....:.|
Yeast 2417 P---ANLKFQK-ALGLHD---KQLTEET---VSLTLNEYVLPTVSKYSDKIKSPESLYLLSSLRL 2471
Fly 2690 -LNPLNLSALLLARLVVDIIPVSSVTTVQQMNALQYSQALCKKQVTEKYANHL-----LANFSSF 2748
||.||...|:..: |:...:.::..::.|.|... ..|| :..|...
Yeast 2472 LLNSLNALKLINEK--------STHGKIDELTYIELSAAAFN-------GRHLKNIPRIPIFCIL 2521
Fly 2749 LEVLHTSLLEDLETADL--DLPQYAHLVTRFHW-FNRILATAQQKLLYNNELHVPLMHKLVLHFQ 2810
..:| |.:.|:|:|..| ...|| :::| ...|:..|.:..:..:|..:.:..:|: ..
Yeast 2522 YNIL-TVMSENLKTESLFCGSNQY-----QYYWDLLVIVIAALETAVTKDEARLRVYKELI--DS 2578
Fly 2811 WLEKHLLVPLIELTAKSGCARMLTIQDRTLKIKKYIEETR-RPLNVTCKIYSKQF-TQFQPYYQD 2873
|:........||:|. .|.| .|:....::.:| ..:.:...|:.|.: |....:...
Yeast 2579 WIASVKSKSDIEITP------FLNI---NLEFTDVLQLSRGHSITLLWDIFRKNYPTTSNSWLAF 2634
Fly 2874 QQIQRHIELDDLEKLLSVVPSYGNLELSSWLKRWLLLQTDDANKWRSFLRKHTNGFQPKAFEISG 2938
:::....|..|..:||....||.::: ...::..
Yeast 2635 EKLINLSEKFDKVRLLQFSESYNSIK--------------------------------DLMDVFR 2667
Fly 2939 SLRNETLQSHLQKLQTTLKEAQENSAEIEMDLELDLNSIKTLLEAETEESESYIHPDGIPTNTPK 3003
.|.::.|.:.|.:....|.:.::...|:|:.....||..|.....|.:....|. ...:|.:
Yeast 2668 LLNDDVLNNKLSEFNLLLSKLEDGINELELISNKFLNKRKHYFADEFDNLIRYT----FSVDTAE 2728
Fly 3004 LL--IAALRELFMERLLTGTLRDDFDEQVNPLYADQLLTLNSN---LWHCLKTLESANRTEITNA 3063
|: :|....|..::| .:|:|...| ::..|.|.::|..|..|:.
Yeast 2729 LIKELAPASSLATQKL------------------TKLITNKYNYPPIFDVLWTEKNAKLTSFTST 2775
Fly 3064 WIE---LKNEVNELQNYDEFAVLLEKIGGGYKGLRSYQRQYRNSVQCYQLENLSTRLDCVQGPSE 3125
... |::.|.:..|...|: ..|.:.|:...:| .||:.:.| .|:.
Yeast 2776 IFSSQFLEDVVRKSNNLKSFS----------------GNQIKQSISDAEL-LLSSTIKC--SPNL 2821
Fly 3126 EGSTDISSQF-CYRGPALSGVILSLICQPNGQLRSVPLSELLEWRSALQQTRHLIWENSQLLTSR 3189
:.||. .|:...||.:...:.....|....:.|.||.
Yeast 2822 -----LKSQMEYYKNMLLSWLRKVIDIHVGGDCLKLTLKELC----------------------- 2858
Fly 3190 YSGEVNNLLQAKENARQLLKELEYV---RKLSEKEQKANQGFENCAKELEKMIEKLEKEENNNAS 3251
:|::.|..:...:...||: ..|:|. :|.||::.| |.
Yeast 2859 ------SLIEEKTASETRVTFAEYIFPALDLAES-----------SKSLEELGE---------AW 2897
Fly 3252 MTKDFEVSLTNALVGAIELCLLTNTPLIDPVEKNRLKNEYIAEDIDCLSTLTTAYDFMKIAMKYR 3316
:| |...|. |..:.::| .||. .::|:..|: .|.|.|.:.:.||.....|
Yeast 2898 IT--FGTGLL--------LLFVPDSP-YDPA-----IHDYVLYDL-FLKTKTFSQNLMKSWRNVR 2945
Fly 3317 HF---GEEIYSELELRLRTALQRQQQLSQKLALRSEKCLYASLVQDITHFLHSNGDCESLYKLFQ 3378
.. .|||::| .|:..| |:.|.....::::
Yeast 2946 KVISGDEEIFTE-----------------------------KLINTI-----SDDDAPQSPRVYR 2976
Fly 3379 L------IHSEWENFQGLHVATSAQLK--------SSIEVLGKLDLWLANAQRFVHHTLSRYSAY 3429
. :..||..|.. ...:|.|:| :|.:...:|::...|:..|::...|.||.
Yeast 2977 TGMSIDSLFDEWMAFLS-STMSSRQIKELVSSYKCNSDQSDRRLEMLQQNSAHFLNRLESGYSK- 3039
Fly 3430 YQDFVEPIKCSVNQLRFGLESLKVIFTRVQQAGSVSQAEQMQQTIGDIVQFPSQHPLVIRNSRLY 3494
:.|..:.:...:..:.||.:.||:..::.:.:..:|....|. |:.|.
Yeast 3040 FADLNDILAGYIYSINFGFDLLKLQKSKDRASFQISPLWSMD-------------PINIS----- 3086
Fly 3495 GLLAELPHSEYEYFRLLKAKLSELSNYIALG--------RVI------------DETTFAAYDDA 3539
.||...|.|. |||.:...| :|: |......::.|
Yeast 3087 --CAENVLSAYH----------ELSRFFKKGDMEDTSIEKVLMYFLTLFKFHKRDTNLLEIFEAA 3139
Fly 3540 LSICNQTWQQEEHRRCQLKAEAESLYVTKTKGGVDSEELIEMQEIEHNFPTNLDEDFAEFVSQ-P 3603
|......|.....|:.|.:.|..::: .|..|.|:..|:|... |
Yeast 3140 LYTLYSRWSVRRFRQEQEENEKSNMF---------------------KFNDNSDDYEADFRKLFP 3183
Fly 3604 TLEQVLKLDKKASAKDKQSQIVVEEDYAFLARNFIDVMTRHTQVYYKEQPKSSKELELHLLAPYQ 3668
..|....: .:.||..|...:::.|..||..:|.|..:.....:..:.||...:
Yeast 3184 DYEDTALV---TNEKDISSPENLDDIYFKLADTYISVFDKDHDANFSSELKSGAII--------- 3236
Fly 3669 ARFQVFANLHGHYKTALGSSLEERACNGLAFGLALQQKQLRDIELEEGVSSSPY---DFYKDSNI 3730
.|.|...|:......|..|.........|.|.:...::..: |||.|.:|
Yeast 3237 -------------TTILSEDLKNTRIEELKSGSLSAVINTLDAETQSFKNTEVFGNIDFYHDFSI 3288
Fly 3731 SEIQSCLDVMERIEKRVLEQLEQYPEHAGLADIKLVISRIRRLPAHAPVVRFNTGFQLLRQKLAL 3795
.|.|...|::|.:.|.||:.|:|:||||.|.::..|.......|...|:.|.....:.:...||.
Yeast 3289 PEFQKAGDIIETVLKSVLKLLKQWPEHATLKELYRVSQEFLNYPIKTPLARQLQKIEQIYTYLAE 3353
Fly 3796 WNEVAHRNNNLVSEEIEVAEFVQRWTRLELQHWRNCLGQTAAQVELQAYRYWFFIYN--LLQQFI 3858
|.:.|....:|.:....:.:.:..|.:|||:.|:.......|:......::||::|. ::..|:
Yeast 3354 WEKYASSEVSLNNTVKLITDLIVSWRKLELRTWKGLFNSEDAKTRKSIGKWWFYLYESIVISNFV 3418
Fly 3859 HQKQLDHSYTDIKLAEQRFAQDHLLDAQDLGESQRLELAQ----VVRILRQFVEASCYGDFHIRL 3919
.:|: |.|. :|..|..|...|..|:|:.||
Yeast 3419 SEKK--------------------------------ETAPNATLLVSSLNLFFSKSTLGEFNARL 3451
Fly 3920 QLLQGFELYLHNVE-RAGKINGLPPLIAALHNLQLYFSQFAGEIADSAKLRRSPIEKKLKEFVKI 3983
.|::.|..::..:. |:.||.|| |||...::.||...|.:.....:..:||::.:.:.:
Yeast 3452 DLVKAFYKHIQLIGLRSSKIAGL------LHNTIKFYYQFKPLIDERITNGKKSLEKEIDDIILL 3510
Fly 3984 QSYSKDLSYFSMRNSVASVHRNLNKFLKEYRLSIQEKISEVFQPKDSTAKDYTFGTDKGKGLRNY 4048
.|: ||::..:::.|....|.||.|.:::|| |....|.....:.|....|.
Yeast 3511 ASW-KDVNVDALKQSSRKSHNNLYKIVRKYR--------------DLLNGDAKTIIEAGLLYSNE 3560
Fly 4049 NKIKYLHTERQQFV------ASEKLLEKFAI----QEEFLSDNTLLQRLDKHFRTARHVVKETLG 4103
||:| |.|.:|.|. ||:.|:::.:. .....:.:|:...:|.:.. |.:..
Yeast 3561 NKLK-LPTLKQHFYEDPNLEASKNLVKEISTWSMRAAPLRNIDTVASNMDSYLE------KISSQ 3618
Fly 4104 QVPYGELITELDDLLASQLERCEHLRSLNVDRSKERP-----QQKQEAKQILQQKRKALTDLFKM 4163
:.| ...||.:......|.|| ||.| :.|:....:..||.|.|.|..|.
Yeast 3619 EFP------NFADLASDFYAEAERLR-------KETPNVYTKENKKRLAYLKTQKSKLLGDALKE 3670
Fly 4164 LHRLGANYKTGLLELSLRNEFEDFQLPPYSIRSMLPRLHPTAQQLDEHLDLYYMKSVFKLKLLQN 4228
|.|:| |:::.| ||.|....|..::|..:.|...:.....|.::.|.:..|..|::
Yeast 3671 LRRIG-------LKVNFR---EDIQKVQSSTTTILANIAPFNNEYLNSSDAFFFKILDLLPKLRS 3725
Fly 4229 IMLTPLSELGPPNIERIKGFAVDLFLLVQQQREHLSGSTKELHELRNSLDSLRKLAEIIPQADIN 4293
....|..::....|||....|..|...:...|..||..|.:..::...:..|.....: :.||.
Yeast 3726 AASNPSDDIPVAAIERGMALAQSLMFSLITVRHPLSEFTNDYCKINGMMLDLEHFTCL--KGDIV 3788
Fly 4294 PSTLNFVKSADIAMEIKQHLRQIHYVLKQWKLLLSCAPSSFIEESENRLLVRKISLAQSELHSLC 4358
.|:| |.::..:. :.::| .||.....::...::.|.| |.||...:.
Yeast 3789 HSSL------------KANVDNVR-LFEKW------LPSLLDYAAQTLSVISKYS-ATSEQQKIL 3833
Fly 4359 IQILNSSQELLNELNNANLEYLSSEKCVTYQKSYAEIQENIKKTLELLRTGQNDYLPLAQPIVEL 4423
:...::........|::.: ..|....:|.:....|.|.:||......||......: |:|.
Yeast 3834 LDAKSTLSSFFVHFNSSRI--FDSSFIESYSRFELFINELLKKLENAKETGNAFVFDI---IIEW 3893
Fly 4424 LDSVQ---LKNHTEIAPEAIDLANADTELANIAHSVLMSMQKIYKHHVKTDEVNQNGEAKEQDEE 4485
:.:.: :|...:..|...|:..| ......|:::|.||:. |:..|...|
Yeast 3894 IKANKGGPIKKEQKRGPSVEDVEQA---FRRTFTSIILSFQKVI------------GDGIESISE 3943
Fly 4486 SKEALQEQHLKKCLTGELTSDWQQLSLPRVLGK-LSNVLLVLKHSHFEGKDKLLCVRRAIGL-LP 4548
:.:.......||.:.. .:|....|:.| :...|.:||...|...:.:. |:..|.. ||
Yeast 3944 TDDNWLSASFKKVMVN------VKLLRSSVVSKNIETALSLLKDFDFTTTESIY-VKSVISFTLP 4001
Fly 4549 VLEQYQLLADYLLLQQLATHKVSAKMLSIVLTVFVEIGSKGFCVPPDLMQDEEGQSKQESKNGEG 4613
|:.:|......:|.:....:..:::.:.|:.|:...:...|||.|....::.:.::.| ||
Yeast 4002 VITRYYNAMTVVLERSRIYYTNTSRGMYILSTILHSLAKNGFCSPQPPSEEVDDKNLQ-----EG 4061
Fly 4614 FGLEDGTG-ENDASDKIESEDQLDDAKRPEDRKDEGDKQEPDCK-EEKGIEMSDDFDAKMQDVEK 4676
.||.||.| :|:..|..:.||..:||: .:.|::.||.|.|.: |:..:||..|...:::|:..
Yeast 4062 TGLGDGEGAQNNNKDVEQDEDLTEDAQ--NENKEQQDKDERDDENEDDAVEMEGDMAGELEDLSN 4124
Fly 4677 PEE-DDSGESEEEEDLNKEMGE-TEEGAEKLDDQIWGDDEEEKPEEEQEPDMN------EEDQGK 4733
.|| ||.....|||:|::|:.: .|:....:||::| ||:.....:|::.|.| |||...
Yeast 4125 GEENDDEDTDSEEEELDEEIDDLNEDDPNAIDDKMW-DDKASDNSKEKDTDQNLDGKNQEEDVQA 4188
Fly 4734 GSKDEKDAHNDLDTKNDA-AKEDGKDEHEKDGLDATNEPSGEDKRKEQAKDIDDMKDPEMDEEQT 4797
...||:...|......|. |.|||.:|.| .|:..|:..|:.:.:|...|||..
Yeast 4189 AENDEQQRDNKEGGDEDPNAPEDGDEEIE------------NDENAEEENDVGEQEDEVKDEEGE 4241
Fly 4798 NAMHNELEEPPEPEEMDLGDMNNVDEGHDDQDEQPTDENPFDIDAMKENMQPAEEPEADGDDEHD 4862
:...| .||.|.:||.:..|:|..|::.|| |:| |.:.|......|..|:::.:
Yeast 4242 DLEAN----VPEIETLDLPEDMNLDSEHEESDE--------DVD-MSDGMPDDLNKEEVGNEDEE 4293
Fly 4863 ANEEGDPQSDGSDSEEDEAGTEAKPAEEDHGEGEEATPEDEKDEAE---TQKRGELEDEDDSKPE 4924
..:|...: ||:|.||.| .|||.||.|.|..|:|..|.: |...|: |||::...|
Yeast 4294 VKQESGIE---SDNENDEPG-----PEEDAGETETALDEEEGAEEDVDMTNDEGK-EDEENGPEE 4349
Fly 4925 DSPEDSKEEKEEKREEKPEEHSQSKDKASKEENVQSMPETDQSSSADQVQQPQD-PDIKQDQKLD 4988
.:..|.:|.|::...| ::|:|.. |:|.:.: |.|::..| .||.|:..:
Yeast 4350 QAMSDEEELKQDAAME------ENKEKGG-EQNTEGL---------DGVEEKADTEDIDQEAAV- 4397
Fly 4989 EQETGEEKDGVGQAENDADDGGHQGVAETQETVSQEDRKNERQTQEKRKQGRTNEERSLGEAEQN 5053
:|::|.: |.|....|..:....|.:.|.:...:||:::..:..|:.::..|...:.||::.:.
Yeast 4398 QQDSGSK--GAGADATDTQEQDDVGGSGTTQNTYEEDQEDVTKNNEESREEATAALKQLGDSMKE 4460
Fly 5054 KLKQLKTIDQLKDSKESDDAEQEKPEPMDQTEAEEYQHVKEPKNSDKTT--LDNATEEQSKKIQH 5116
..::.:.|.:.:.:.|.|:..::..|..| |::|| |..|::..| |.:||::|.:.|..
Yeast 4461 YHRRRQDIKEAQTNGEEDENLEKNNERPD-----EFEHV-EGANTETDTQALGSATQDQLQTIDE 4519
Fly 5117 QEDEPPNEEEIEAENVDELMEAEEPAVDPEDDAELEQLGAEKTEQKSDKPSK------TEKSKEQ 5175
......:.||.|.:..:.:.:|::..:|.:::..|..:.|. :..:|..|| ..||:|
Yeast 4520 DMAIDDDREEQEVDQKELVEDADDEKMDIDEEEMLSDIDAH--DANNDVDSKKSGFIGKRKSEE- 4581
Fly 5176 LETPEGMEIEGEVVLTMTVPRSSETTAHSNSEILLDKSSHAEDLSSAEQIELRQQYQKQLTTFRV 5240
:.|.|: ||.....|:...:|..|..|.||..........|
Yeast 4582 -------DFENEL---------------SNEHFSADQEDDSEIQSLIENIEDNPPDASASLT--- 4621
Fly 5241 AQPE---HEDYETWQGISNRMTQNARELCEQLRLILEPTKCTRLKGDYRTGRRINMKKIIPYIAS 5302
|| .|..|.|.............|.||||||||||..|:|||||:||:|:|||:|||||||
Yeast 4622 --PERSLEESRELWHKSEISTADLVSRLGEQLRLILEPTLATKLKGDYKTGKRLNMKRIIPYIAS 4684
Fly 5303 QFRKDKIWLRRTKPAQRDYKITIAIDDSKSMHHNNSKTLTLEAISLVSQALTLLESGRLSIVSFG 5367
||||||||||||||::|.|:|.||:||||||..:....|..:::.|||:.||.||:|.||||.||
Yeast 4685 QFRKDKIWLRRTKPSKRQYQIMIALDDSKSMSESKCVKLAFDSLCLVSKTLTQLEAGGLSIVKFG 4749
Fly 5368 EAPQIILNHTEQF---DGPRLVNALNFAQDKTKIAGLLNFIRTANAEESGTGGDNGLFE------ 5423
|..:.:.:..:|| .|.|......|.:.||.:..|: ||.: .:||
Yeast 4750 ENIKEVHSFDQQFSNESGARAFQWFGFQETKTDVKKLV-------AEST------KIFERARAMV 4801
Fly 5424 -----NLLLILSDGRNIFSEGAQNVKNAIKLARLQRIFLVYIIIDNPDNKNSILDIQHVAVNAD- 5482
.|.:::||| ..|..:.::..::.||..:|.||::|||...:..||||:..|....|
Yeast 4802 HNDQWQLEIVISDG---ICEDHETIQKLVRRARENKIMLVFVIIDGITSNESILDMSQVNYIPDQ 4863
Fly 5483 ---GSVNINSYLDSFPFPYYVIVRDLNQLPLVLSEAMRQWF-ELVNS 5525
..:.|..|||:|||.:||:|.|:::||.:||..:||:| :|.:|
Yeast 4864 YGNPQLKITKYLDTFPFEFYVVVHDISELPEMLSLILRQYFTDLASS 4910
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