DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG13185 and TWD1

DIOPT Version :9

Sequence 1:	NP_001097279.2	Gene:	CG13185 / 36268	FlyBaseID:	FBgn0033661	Length:	5526	Species:	Drosophila melanogaster
Sequence 2:	NP_188801.2	Gene:	TWD1 / 821718	AraportID:	AT3G21640	Length:	365	Species:	Arabidopsis thaliana

Alignment Length:	396	Identity:	80/396 - (20%)
Similarity:	133/396 - (33%)	Gaps:	153/396 - (38%)

- Green bases have known domain annotations that are detailed below.

  Fly  3537 DDALSICNQTWQQEEHRRCQLKAEAESLYVTKTKGGVDSEELIEMQEIEHNFPTNLDEDFAEFVS 3601
            |::|....||..|            ||..||:....|.||     ...|.|.|..:|.: ||.:.
plant     2 DESLEHQTQTHDQ------------ESEIVTEGSAVVHSE-----PSQEGNVPPKVDSE-AEVLD 48

  Fly  3602 QPTLEQVLKLDKKASAKDKQSQIVVEEDYAFLARNFIDVMTRH--TQVYYKEQPKSSKELELHLL 3664
            :...:|::| :...|...|.|...:.  |....:|     ::|  ...::::||     :||
plant    49 EKVSKQIIK-EGHGSKPSKYSTCFLH--YRAWTKN-----SQHKFEDTWHEQQP-----IEL--- 97

  Fly  3665 APYQARFQVFANLHGHYKTALGSSLEERACNGLAFGLALQQKQLRDI-----EL---EEGVSSSP 3721
                               .||...:|.|  |||.|:|..:...|.:     ||   :||..|.|
plant    98 -------------------VLGKEKKELA--GLAIGVASMKSGERALVHVGWELAYGKEGNFSFP 141

  Fly  3722 ---------YDF----YKDSNISEIQSCLDVMERI---------------EKRVLEQLEQYPE-- 3756
                     |:.    :.::...:.:|.:.|.|||               |:::.|.::||..
plant   142 NVPPMADLLYEVEVIGFDETKEGKARSDMTVEERIGAADRRKMDGNSLFKEEKLEEAMQQYEMAI 206

  Fly  3757 -----------HAGLADIKLVISRIRRLPAHAPVVRFNTGFQLLRQKLALWNE-VAHRNNNLVSE 3809
                       :....|:.|.:..    |.|     .|....|:  ||..::| :.|.|..|..|
plant   207 AYMGDDFMFQLYGKYQDMALAVKN----PCH-----LNIAACLI--KLKRYDEAIGHCNIVLTEE 260

  Fly  3810 EIEVAEFVQRWTRLELQHWRNCLGQTAAQVELQAYRYWFFIYNLLQQFIHQKQLDHSYTDIKLAE 3874
            |.......:|             |:..|::                     .|:|.:..|.:.|
plant   261 EKNPKALFRR-------------GKAKAEL---------------------GQMDSARDDFRKA- 290

  Fly  3875 QRFAQD 3880
            |::|.|
plant   291 QKYAPD 296

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG13185	NP_001097279.2	MDN1	298..5521	CDD:227596	80/396 (20%)
		P-loop_NTPase	315..505	CDD:304359
		P-loop_NTPase	<887..972	CDD:304359
		P-loop_NTPase	1147..1283	CDD:304359
		P-loop_NTPase	1454..1603	CDD:304359
		P-loop_NTPase	1795..1946	CDD:304359
		P-loop_NTPase	<2335..>2378	CDD:304359
		Prothymosin	4843..4920	CDD:281265
		PHA03151	4856..5060	CDD:177546
		MttA_Hcf106	<5046..5166	CDD:294511
		vWA_midasin	5261..5526	CDD:238737
TWD1	NP_188801.2	FKBP_C	62..156	CDD:395196	27/129 (21%)
		PRK15331	196..310	CDD:357168	27/147 (18%)
		TPR repeat	230..259	CDD:276809	10/39 (26%)
		TPR repeat	264..292	CDD:276809	7/62 (11%)
		TPR repeat	298..323	CDD:276809
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910