DRSC/TRiP Functional Genomics Resources

powered by:
logo

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment CG13185 and NCL

DIOPT Version :9

Sequence 1:NP_001097279.2 Gene:CG13185 / 36268 FlyBaseID:FBgn0033661 Length:5526 Species:Drosophila melanogaster
Sequence 2:NP_005372.2 Gene:NCL / 4691 HGNCID:7667 Length:710 Species:Homo sapiens


Alignment Length:723 Identity:154/723 - (21%)
Similarity:253/723 - (34%) Gaps:202/723 - (27%)


- Green bases have known domain annotations that are detailed below.


  Fly  4645 KDEGD--KQEPDCKEEKGIEMSDDFDAKMQDVEKPEEDDSGESEEEEDLNKEMGE--TEEGAEKL 4705
            |::||  |..|..||.:  |.|:|     :::.:.|||||  |.||..:.::.|:  ....|:|:
Human     9 KNQGDPKKMAPPPKEVE--EDSED-----EEMSEDEEDDS--SGEEVVIPQKKGKKAAATSAKKV 64

  Fly  4706 DDQIWGDDEEEKPEEEQEPDMNEEDQGKGSKDEKDAHNDLDTKNDAAKEDGKDEHEKDGLDATNE 4770
            ............|.::......::.....:|........:.|........||      .|.||..
Human    65 VVSPTKKVAVATPAKKAAVTPGKKAAATPAKKTVTPAKAVTTPGKKGATPGK------ALVATPG 123

  Fly  4771 PSGEDKRKEQAKDIDDMKDPEMDEEQTNAMHNELEEPPEPEEMDLGDMNNVDEGHDDQDEQPTDE 4835
            ..|.....:.||:..:.|..:.|||       |.::..|.||             ||:||. .||
Human   124 KKGAAIPAKGAKNGKNAKKEDSDEE-------EDDDSEEDEE-------------DDEDED-EDE 167

  Fly  4836 NPFDIDAMK-ENMQPAEEPEADGDDEHDANEEGDPQSDGSDSEEDEAGT--------------EA 4885
            :..:..||| ....||.|.|.|.|||.|.:::.|.:   .||||:...|              :|
Human   168 DEIEPAAMKAAAAAPASEDEDDEDDEDDEDDDDDEE---DDSEEEAMETTPAKGKKAAKVVPVKA 229

  Fly  4886 KPAEEDHGEGEEATPEDEKDEAETQKRGELEDEDDSKPEDSPEDSKEEKEEKREEKP--EEHSQS 4948
            |...||..|.|:...||:.|:         ||::|...||..|:.:||:||..:|.|  .:...:
Human   230 KNVAEDEDEEEDDEDEDDDDD---------EDDEDDDDEDDEEEEEEEEEEPVKEAPGKRKKEMA 285

  Fly  4949 KDKASKEENVQ----------------------SMPE---------------------------- 4963
            |.||:.|...|                      |.||                            
Human   286 KQKAAPEAKKQKVEGTEPTTAFNLFVGNLNFNKSAPELKTGISDVFAKNDLAVVDVRIGMTRKFG 350

  Fly  4964 -TDQSSSAD-----------------QVQQPQDPDIKQDQ------------KLDEQETGEEKDG 4998
             .|..|:.|                 ::::|:..|.|:::            |:.:.|..|..:.
Human   351 YVDFESAEDLEKALELTGLKVFGNEIKLEKPKGKDSKKERDARTLLAKNLPYKVTQDELKEVFED 415

  Fly  4999 VGQAENDADDGGHQGVAETQETVSQEDRKNERQTQEKRKQGRTNEERSLGEAEQNKLKQLKTIDQ 5063
            ..:....:.||..:|:|..:.....:..|...:.|.....||:......||..||:        .
Human   416 AAEIRLVSKDGKSKGIAYIEFKTEADAEKTFEEKQGTEIDGRSISLYYTGEKGQNQ--------D 472

  Fly  5064 LKDSKESDDAEQEK-----------PEPMDQTEAEEYQHVKEPKNSDKTT-----LDNATEEQSK 5112
            .:..|.|..:.:.|           .|...|...|:...:|.|:|.:..:     ::.|:.|.:|
Human   473 YRGGKNSTWSGESKTLVLSNLSYSATEETLQEVFEKATFIKVPQNQNGKSKGYAFIEFASFEDAK 537

  Fly  5113 KIQHQEDEPPNEEEIEAENVDELMEAEEPAVDPEDDAELEQLGAEKTEQKSDKPSKT--EKSKEQ 5175
            :..:.    .|:.|||...:                 .||..|...:.....:||||  .|...:
Human   538 EALNS----CNKREIEGRAI-----------------RLELQGPRGSPNARSQPSKTLFVKGLSE 581

  Fly  5176 LETPEGME--IEGEVVLTMTVPRSSETTAHSNSEILLDKSSHAEDLSSAEQIELRQQYQKQLTTF 5238
            ..|.|.::  .:|.|...:...|.   |..|.....:|.:|. ||..:|::.....:......|.
Human   582 DTTEETLKESFDGSVRARIVTDRE---TGSSKGFGFVDFNSE-EDAKAAKEAMEDGEIDGNKVTL 642

  Fly  5239 RVAQPEHE 5246
            ..|:|:.|
Human   643 DWAKPKGE 650

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
CG13185NP_001097279.2 MDN1 298..5521 CDD:227596 154/723 (21%)
P-loop_NTPase 315..505 CDD:304359
P-loop_NTPase <887..972 CDD:304359
P-loop_NTPase 1147..1283 CDD:304359
P-loop_NTPase 1454..1603 CDD:304359
P-loop_NTPase 1795..1946 CDD:304359
P-loop_NTPase <2335..>2378 CDD:304359
Prothymosin 4843..4920 CDD:281265 28/91 (31%)
PHA03151 4856..5060 CDD:177546 61/299 (20%)
MttA_Hcf106 <5046..5166 CDD:294511 23/135 (17%)
vWA_midasin 5261..5526 CDD:238737
NCLNP_005372.2 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..303 90/341 (26%)
8 X 8 AA tandem repeats of X-T-P-X-K-K-X-X 58..135 11/82 (13%)
RRM1_NCL 307..381 CDD:240849 6/73 (8%)
RRM 379..628 CDD:223796 54/281 (19%)
RRM2_NCL 390..465 CDD:240850 11/74 (15%)
RRM3_NCL 485..557 CDD:240851 15/92 (16%)
RRM4_NCL 572..649 CDD:240852 18/80 (23%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 640..710 4/11 (36%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
10.910

Return to query results.
Submit another query.