DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG13185 and LPL

DIOPT Version :9

Sequence 1:	NP_001097279.2	Gene:	CG13185 / 36268	FlyBaseID:	FBgn0033661	Length:	5526	Species:	Drosophila melanogaster
Sequence 2:	NP_000228.1	Gene:	LPL / 4023	HGNCID:	6677	Length:	475	Species:	Homo sapiens

Alignment Length:	457	Identity:	85/457 - (18%)
Similarity:	160/457 - (35%)	Gaps:	142/457 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly  3335 QRQQ--QLSQKLALRS------EKC-LYASLVQDIT--HFLHSNGDCESLYKLFQLIHSEWENFQ 3388
            ||:.  .:..|.|||:      :.| |...:.:.:.  ||.||:       |.|.:||. | ...
Human    30 QRRDFIDIESKFALRTPEDTAEDTCHLIPGVAESVATCHFNHSS-------KTFMVIHG-W-TVT 85

  Fly  3389 GLHVATSAQL---------KSSIEVLGKLDLWLANAQRFVHHTLSRYSAYY-----QDFVEPIKC 3439
            |::.:...:|         .|::.|:.    ||:.||.  |:.:   ||.|     ||....|..
Human    86 GMYESWVPKLVAALYKREPDSNVIVVD----WLSRAQE--HYPV---SAGYTKLVGQDVARFINW 141

  Fly  3440 SVNQLRFGLESLKVIFTRVQQ-----AGSVSQAEQMQQTIGDIVQFPSQHPLVIRNSRLYGLLAE 3499
            ...:..:.|:::.::...:..     |||::..                     :.:|:.||...
Human   142 MEEEFNYPLDNVHLLGYSLGAHAAGIAGSLTNK---------------------KVNRITGLDPA 185

  Fly  3500 LPHSEYEYFRLLKAKLSELSNYIALGRVIDET-------TFAAYDDALSICNQ------------ 3545
            .|:.||..   ..::||.           |:.       ||.......||..|
Human   186 GPNFEYAE---APSRLSP-----------DDADFVDVLHTFTRGSPGRSIGIQKPVGHVDIYPNG 236

  Fly  3546 -TWQQEEHRRCQLKAEAESLYVTKTKGGVDSEELIEMQEIEHNFPTNLDEDFAEFVSQPTLEQVL 3609
             |:|.    .|.:   .|::.|...:|..|.::|:   :..|....:|           .::.:|
Human   237 GTFQP----GCNI---GEAIRVIAERGLGDVDQLV---KCSHERSIHL-----------FIDSLL 280

  Fly  3610 KLDKKASAKDKQSQIVVEEDYAFLARNFIDVMTRHTQVYYK-EQPKSSKELELHLLAPYQARFQV 3673
            ..:..:.|....|:...|:......|.     .|...:.|: .:.::.:..:::|....|..::|
Human   281 NEENPSKAYRCSSKEAFEKGLCLSCRK-----NRCNNLGYEINKVRAKRSSKMYLKTRSQMPYKV 340

  Fly  3674 FANLHGHYKTALG-SSLEERACNGLAFGLAL----QQKQLRDIELEEGVSSSPYDF--YKDSNIS 3731
            |     ||:..:. |..|.......||.::|    .:.:.....|.|..::..|.|  |.:.:|.
Human   341 F-----HYQVKIHFSGTESETHTNQAFEISLYGTVAESENIPFTLPEVSTNKTYSFLIYTEVDIG 400

  Fly  3732 EI 3733
            |:
Human   401 EL 402

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG13185	NP_001097279.2	MDN1	298..5521	CDD:227596	85/457 (19%)
		P-loop_NTPase	315..505	CDD:304359
		P-loop_NTPase	<887..972	CDD:304359
		P-loop_NTPase	1147..1283	CDD:304359
		P-loop_NTPase	1454..1603	CDD:304359
		P-loop_NTPase	1795..1946	CDD:304359
		P-loop_NTPase	<2335..>2378	CDD:304359
		Prothymosin	4843..4920	CDD:281265
		PHA03151	4856..5060	CDD:177546
		MttA_Hcf106	<5046..5166	CDD:294511
		vWA_midasin	5261..5526	CDD:238737
LPL	NP_000228.1	Interaction with GPIHBP1. /evidence=ECO:0000269\|PubMed:30559189	32..53		4/20 (20%)
		Lipase	33..473	CDD:332983	83/454 (18%)
		Essential for determining substrate specificity. /evidence=ECO:0000269\|PubMed:7592706	243..266		6/28 (21%)
		Important for interaction with lipoprotein particles. /evidence=ECO:0000269\|PubMed:27929370	417..421
		Important for heparin binding. /evidence=ECO:0000269\|PubMed:11342582	430..434
		Interaction with GPIHBP1. /evidence=ECO:0000269\|PubMed:26725083, ECO:0000269\|PubMed:30559189	443..467
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910