DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG13185 and lgc-38

DIOPT Version :9

Sequence 1:	NP_001097279.2	Gene:	CG13185 / 36268	FlyBaseID:	FBgn0033661	Length:	5526	Species:	Drosophila melanogaster
Sequence 2:	NP_001355511.1	Gene:	lgc-38 / 3565717	WormBaseID:	WBGene00017389	Length:	479	Species:	Caenorhabditis elegans

Alignment Length:	427	Identity:	85/427 - (19%)
Similarity:	144/427 - (33%)	Gaps:	105/427 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly  5064 LKDSKESDDAEQEKPEPMDQTEAEEYQHVKEPKNSDKTTLDNATEEQSKKIQHQEDEPPNEEEIE 5128
            :|..|..:.|.|...||....|:.|     ..:|:....||.......::|:.....||.|..|.
Worm    22 MKSDKLIEYAPQASTEPTLGGESNE-----NLENNVTRLLDKLIASHDRRIRPNYGGPPIEVNIT 81

  Fly  5129 AENVDELMEAEEPAVDPEDDAELEQLGAEKTEQKSDKPSKTEKSKEQLETPEGMEIEGEVVLTMT 5193
            | :|..:....|.::|...|..|.|:.            |..:...:.:..:.:.|..::|.|:.
Worm    82 A-HVTTISAVSEVSMDYTLDLYLRQIW------------KDPRLAWESDVEDSLTIGIDMVKTIW 133

  Fly  5194 VPRS----------SETTAHSNSEILLDKSSHAEDLSSAEQIELRQQYQKQLTTFRV------AQ 5242
            .|.:          .|.|:| ||.:.:|  :|...|.|. ::.:.......|.||.:      .:
Worm   134 TPDTFFPNEKKSFFHEATSH-NSFLRID--NHGNVLRSI-RLTVTANCPMSLHTFPLDRQECALE 194

  Fly  5243 PEHEDYET------WQGISNRMTQNARELCEQLRLI---------------LEPTKCTRLKGDYR 5286
            .|...|.|      |.|      .||..:.|.:.|.               |.....:||...:.
Worm   195 VESYGYSTKDIIYHWHG------TNAVTIDENVHLAHFTIGEHKHIERTISLSTGNYSRLTAYFL 253

  Fly  5287 TGRRINMKKIIPYIASQFRKDKIWL-----RRTKPAQRDYKITIAIDDSKSMHHNNSKTLTLEAI 5346
            ..|.|....|..|..|.......|:     |....|:....:|..:..:..|...|:   :|..:
Worm   254 FKRNIGFYLIQIYFPSSLIVVISWVSFWLNREAVQARVAIGVTTVLTMTTLMTSTNA---SLPKV 315

  Fly  5347 SLVSQA------------LTLLESGRLSIV-----SFGEAPQIILNHTEQF----DGPRLV-NAL 5389
            |.|...            .:|||...:..:     |...|..:....||:|    ..|:.| .|:
Worm   316 SYVKSLDVFLGVCFFIVFASLLEYAAIGYLMKRNRSVPAASPVQYYETEEFFEIQCHPKFVRGAI 380

  Fly  5390 NFAQDKTKIAGLLNFIRTANAEESGTGGDNGL--FEN 5424
            |:..      |:|.  |.|:.::|....|:.:  ::|
Worm   381 NYCD------GVLK--REASRKKSRNRRDSSMKNYQN 409

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG13185	NP_001097279.2	MDN1	298..5521	CDD:227596	85/427 (20%)
		P-loop_NTPase	315..505	CDD:304359
		P-loop_NTPase	<887..972	CDD:304359
		P-loop_NTPase	1147..1283	CDD:304359
		P-loop_NTPase	1454..1603	CDD:304359
		P-loop_NTPase	1795..1946	CDD:304359
		P-loop_NTPase	<2335..>2378	CDD:304359
		Prothymosin	4843..4920	CDD:281265
		PHA03151	4856..5060	CDD:177546
		MttA_Hcf106	<5046..5166	CDD:294511	23/101 (23%)
		vWA_midasin	5261..5526	CDD:238737	40/208 (19%)
lgc-38	NP_001355511.1	LIC	42..476	CDD:273305	79/407 (19%)
		LGIC_ECD_GABAR_RDL-like	76..257	CDD:349809	38/203 (19%)
		Cys-loop	177..191	CDD:349809	3/13 (23%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910