DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG13185 and dpy

DIOPT Version :9

Sequence 1:	NP_001097279.2	Gene:	CG13185 / 36268	FlyBaseID:	FBgn0033661	Length:	5526	Species:	Drosophila melanogaster
Sequence 2:	NP_001260032.1	Gene:	dpy / 318824	FlyBaseID:	FBgn0053196	Length:	22949	Species:	Drosophila melanogaster

Alignment Length:	659	Identity:	123/659 - (18%)
Similarity:	207/659 - (31%)	Gaps:	225/659 - (34%)

- Green bases have known domain annotations that are detailed below.

  Fly  4796 QTNAMHNELEEPPEPEEMDLGDMNNVDEGHDDQDEQPTDENPFDIDAMKENMQPAEEPEADGDDE 4860
            ||.|..:|:......||..|             ..:.||..           .|:|.||......
  Fly  6712 QTTATPSEVRTTIRVEESTL-------------PSRSTDRT-----------TPSESPETPTTLP 6752

  Fly  4861 HDANEEGDPQSD-GSDSEEDEAGTEAKPAEEDHGEGEEATPEDEKDEAET-----QKRGELEDED 4919
            .|....  |.|| .::|..|...|....|........|.|......|..|     ...|::.::.
  Fly  6753 SDFTTR--PHSDQTTESTRDVPTTRPFEASTPSPASLETTVPSVTSETTTNVPIGSTGGQVTEQT 6815

  Fly  4920 DSKPEDSPEDSKEEKEEKREEKPEEHSQSKDKASKEENVQSMPETDQSSSADQVQQPQDPDIKQD 4984
            .|.|       .|.:.....|:....|:|.|:.|..|:    |||..:..:|.:.:|.
  Fly  6816 TSSP-------SEVRTTIGLEESTLPSRSTDRTSPSES----PETPTTLPSDFITRPH------- 6862

  Fly  4985 QKLDEQETGEEKDGVGQAENDADDGGHQGVAETQETVSQEDRKN----------ERQTQEKRKQG 5039
               .:|.|...:|.......:|.......:..|..:|:.|...|          ..||.....:.
  Fly  6863 ---SDQTTESTRDVPTTRPFEASTPSPASLETTVPSVTSETTTNVPIGSTGGQVTEQTTSSPSEV 6924

  Fly  5040 RTN---EERSLGEAEQNKLKQLKTIDQLKDSKESD-DAEQEKPE-----PMDQTEAEEYQHVKEP 5095
            ||.   ||.:|                  .|:.:| .:..|.||     |.|        .:..|
  Fly  6925 RTTIGLEESTL------------------PSRSTDRTSPSESPETPTTLPSD--------FITRP 6963

  Fly  5096 KNSDKTTLDNATEEQSKKIQHQEDEPPNEEEIEAENVDEL-MEAEEPAVDPE--DDAELEQLGAE 5157
             :||:||      |.::.:       |.....||...... :|...|:|..|  .:..:...|.:
  Fly  6964 -HSDQTT------ESTRDV-------PTTRPFEASTPSSASLETTVPSVTLETTTNVPIGSTGGQ 7014

  Fly  5158 KTEQKSDKPSK---------------------------------------------TEKSKE--- 5174
            .|||.:..||:                                             ||.|::
  Fly  7015 VTEQTTSSPSEVRTTIRVEESTLPSRSTDRTTPSESPETPTTLPSDFTTRPHSDQTTESSRDVPT 7079

  Fly  5175 ----QLETPEGMEIEGEVVLTMTVPRSSETTAHSNSEILLDKSSHAEDLSSAEQIELRQQYQKQL 5235
                :..||..:.::     |..:|.:||||  :|..|........|..:|:.. |:|
  Fly  7080 TQPFEASTPRPVTLQ-----TAVLPVTSETT--TNVPIGSTGGQVTEQTTSSPS-EVR------- 7129

  Fly  5236 TTFRVAQ----------------PE-----HEDYETWQGISNRMTQNARELCEQLRLILEPTKCT 5279
            ||.||.:                ||     ..|:.| :..|::.|:::|::         |   |
  Fly  7130 TTIRVEESTLPSRSTDRTTPSESPETPTTLPSDFTT-RPHSDQTTESSRDV---------P---T 7181

  Fly  5280 RLKGDYRTGRRINMKKIIPYIASQFRKD--------KIWLRRTKPAQRDYKITIAIDDSKSMHHN 5336
            ....:..|.|.:.::..:|.:.|:...:        :: ..:|.|:..:.:.||.|::|.....:
  Fly  7182 TQPFESSTPRPVTLETAVPPVTSETTTNVPIGSTGGQV-TEQTTPSPSEVRTTIRIEESTFPSRS 7245

  Fly  5337 NSKTLTLEA 5345
            ..:|...|:
  Fly  7246 TDRTTPSES 7254

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG13185	NP_001097279.2	MDN1	298..5521	CDD:227596	123/659 (19%)
		P-loop_NTPase	315..505	CDD:304359
		P-loop_NTPase	<887..972	CDD:304359
		P-loop_NTPase	1147..1283	CDD:304359
		P-loop_NTPase	1454..1603	CDD:304359
		P-loop_NTPase	1795..1946	CDD:304359
		P-loop_NTPase	<2335..>2378	CDD:304359
		Prothymosin	4843..4920	CDD:281265	17/82 (21%)
		PHA03151	4856..5060	CDD:177546	42/222 (19%)
		MttA_Hcf106	<5046..5166	CDD:294511	25/128 (20%)
		vWA_midasin	5261..5526	CDD:238737	15/93 (16%)
dpy	NP_001260032.1	EGF_3	137..166	CDD:289699
		EGF_CA	212..247	CDD:238011
		EGF_CA	255..>286	CDD:214542
		EGF_CA	298..331	CDD:238011
		EGF_CA	338..373	CDD:238011
		EGF_CA	413..456	CDD:238011
		EGF_CA	457..490	CDD:238011
		EGF_CA	497..>529	CDD:214542
		EGF_CA	580..>612	CDD:214542
		EGF_3	676..702	CDD:289699
		EGF_CA	1022..1056	CDD:214542
		EGF_CA	2227..2260	CDD:238011
		EGF_CA	2393..>2422	CDD:214542
		DUF4758	4088..4282	CDD:292572
		DUF4696	4127..4678	CDD:292395
		DUF4758	4275..4448	CDD:292572
		DUF4758	4377..4574	CDD:292572
		DUF4758	4581..4754	CDD:292572
		DUF4758	4683..4847	CDD:292572
		DUF4758	4785..4964	CDD:292572
		DUF4696	4841..5385	CDD:292395
		DUF4758	4887..5098	CDD:292572
		DUF4758	5193..5371	CDD:292572
		DUF4758	5294..5487	CDD:292572
		DUF4758	5445..5650	CDD:292572
		DUF4758	5700..5877	CDD:292572
		DUF4696	5756..6396	CDD:292395
		DUF4758	5802..5979	CDD:292572
		DUF4758	5964..6171	CDD:292572
		DUF4758	6181..6360	CDD:292572
		DUF4696	6339..6999	CDD:292395	73/373 (20%)
		DUF4758	6662..6839	CDD:292572	32/159 (20%)
		DUF4758	6764..6941	CDD:292572	39/215 (18%)
		DUF4758	6866..7045	CDD:292572	40/218 (18%)
		DUF4758	6968..7179	CDD:292572	44/239 (18%)
		DUF4696	7024..7569	CDD:292395	43/260 (17%)
		DUF4758	7172..7383	CDD:292572	16/96 (17%)
		DUF4696	7330..7964	CDD:292395
		DUF4758	7400..7587	CDD:292572
		DUF4758	7538..7707	CDD:292572
		DUF4758	7798..7979	CDD:292572
		DUF4758	7946..8126	CDD:292572
		YppG	18767..>18832	CDD:290883
		Med25_SD1	18795..18955	CDD:288132
		MISS	19026..19258	CDD:292450
		ZP	22576..22811	CDD:214579
		Zona_pellucida	<22714..22810	CDD:278526
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	1	0.910