DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG13185 and Muc68E

DIOPT Version :9

Sequence 1:	NP_001097279.2	Gene:	CG13185 / 36268	FlyBaseID:	FBgn0033661	Length:	5526	Species:	Drosophila melanogaster
Sequence 2:	NP_996064.1	Gene:	Muc68E / 2768990	FlyBaseID:	FBgn0053265	Length:	1799	Species:	Drosophila melanogaster

Alignment Length:	861	Identity:	184/861 - (21%)
Similarity:	282/861 - (32%)	Gaps:	247/861 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly  4592 VPPDLMQDEEGQSKQESKNGEGFGLEDGTGENDASDKIESEDQLDDAKRPEDRKDEGDK------ 4650
            |..|...|.||.:               |.|:|.:..||:     ..::|||.....|.
  Fly   630 VAQDTTNDPEGST---------------TREDDTTVAIET-----TTEKPEDDTTAEDSTPIPEE 674

  Fly  4651 -----QEPDCKEEKGIEMSDDFDAKMQ-DVEKPEEDDSGES-----EEEEDLNKEMGETEEGA-- 4702
                 ||.....|......||....:: ..||||:|.:.|.     ||...:.:|.....||:
  Fly   675 STTVAQETTYDPEGSTTREDDTTVAIETTTEKPEDDTTVEDSTPIPEESTTVAQETTYDPEGSTT 739

  Fly  4703 -------------EKLDDQIWGDDEEEKPEEEQEPDMNEEDQGKGSKDEKDAHNDLDT------- 4747
                         ||.:|....:|....|||......:..:..:||...:|     ||
  Fly   740 REDDTTVAIETTTEKPEDDTTAEDSTPIPEESTTVAQDTTNDPEGSTTRED-----DTTVAIETT 799

  Fly  4748 ----KNDAAKEDG---KDEHEKDGLDATNEPSGEDKRKEQA---------KDIDDMK-------- 4788
                ::|...||.   .:|....|.:.|.:|.|...|:|..         |..||..
  Fly   800 TEKREDDTTVEDSTPIPEETTTVGQETTYDPEGSTTREEDTTVAIETTTEKPEDDTTAEDSTPIP 864

  Fly  4789 ------------DPE----MDEEQTNAMHNELEE----------PPEPEEMD--LGDMNNVDEGH 4825
                        |||    .:::.|.||....|:          .|.|||..  ..|..|..||.
  Fly   865 EESTTVAQETTYDPEGSTTREDDTTVAMETTTEKREDDTTVEDSTPIPEESTTVAQDTTNDPEGS 929

  Fly  4826 DDQDE------QPTDENPFDIDAMKENMQPAEEPEADGDDEHDANEEGDPQSDGSDSEEDEA--- 4881
            ..::|      :.|.|.|.|...::::....||....|.:     ...||  :||.:.||:.
  Fly   930 TTREEDTTVAIETTTEKPEDDTTVEDSTPIPEETTTVGQE-----TTYDP--EGSTTREDDTTVA 987

  Fly  4882 --GTEAKPAEEDHGEGEEATPEDEKDEAETQ-----KRGELEDEDDS---------KPEDS---- 4926
              .|..||  ||....|::||..|:.....|     ..|....|||:         ||||.
  Fly   988 IDTTTEKP--EDDTTVEDSTPIPEESTTVAQDTTNDPEGSTTREDDTTVAIDTTTEKPEDDTTVE 1050

  Fly  4927 -----PEDSKEEKEE---------KRE-----------EKPEEHSQSKDKASKEENVQSMPETDQ 4966
                 ||:|....:|         .||           ||||:.:..:|..       .:||...
  Fly  1051 DSTPIPEESTTIAQETTYDPEGSTTREDDTTVAIETTTEKPEDDTTVEDST-------PIPEEST 1108

  Fly  4967 SSSADQVQQPQDPDIKQDQKLDEQETGEEKDGVGQAENDADDGGHQGVAETQETVSQEDRKNERQ 5031
            :.:.|....|:....::|......:|..||........|:.....:.....|:|.:..:....|:
  Fly  1109 TVAQDTTNDPEGSTTREDDTTVAIDTTTEKPEDDTTVEDSTPIPEESTTVAQDTTNDPEGSTTRE 1173

  Fly  5032 ---------TQEKRKQGRTNEERSLGEAEQNKLKQLKTID-QLKDSKESD-----DAEQEKPEPM 5081
                     |.||.:...|.|:.:....|...:.|..|.| :...::|.|     |...||||
  Fly  1174 EDTTVAIETTTEKPEDDTTVEDSTPIPEETTTVGQETTYDPEGSTTREDDTTVAIDTTTEKPE-- 1236

  Fly  5082 DQTEAEEYQHVKE------------PKNS----DKTT--LDNATEEQSKKIQHQEDEP-PNEEEI 5127
            |.|..|:...:.|            |:.|    |.||  :|..||:.......::..| |.|...
  Fly  1237 DDTTVEDSTPIPEESTTVAQDTTNDPEGSTTREDDTTVAIDTTTEKPEDDTTVEDSTPIPEESTT 1301

  Fly  5128 EAENV------------DELMEAEEPAVDPEDDAELEQ----------LGAEKTEQKSDKPSKTE 5170
            .|::.            |..:..:.....||||..:|.          :..|.|.......::.:
  Fly  1302 VAQDTTNDPEGSTTREDDTTVAIDTTTEKPEDDTTVEDSTPIPEESTTIAQETTYDPEGSTTRED 1366

  Fly  5171 KSKEQLE-TPEGMEIEGEVVLTMTVPRSSETTAHSNSEILLDKSSHAEDLSSAEQIELRQQYQKQ 5234
            .:...:| |.|..|.:..|..:..:|..|.|.|...:......::..||.:.|  ||...:..:.
  Fly  1367 DTTVAIETTTEKPEDDTTVEDSTPIPEESTTVAQDTTNDPEGSTTREEDTTVA--IETTTEKPED 1429

  Fly  5235 LTTFRVAQPEHEDYET 5250
            .||...:.|..|:..|
  Fly  1430 DTTVEDSTPIPEETTT 1445

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG13185	NP_001097279.2	MDN1	298..5521	CDD:227596	184/861 (21%)
		P-loop_NTPase	315..505	CDD:304359
		P-loop_NTPase	<887..972	CDD:304359
		P-loop_NTPase	1147..1283	CDD:304359
		P-loop_NTPase	1454..1603	CDD:304359
		P-loop_NTPase	1795..1946	CDD:304359
		P-loop_NTPase	<2335..>2378	CDD:304359
		Prothymosin	4843..4920	CDD:281265	21/86 (24%)
		PHA03151	4856..5060	CDD:177546	55/260 (21%)
		MttA_Hcf106	<5046..5166	CDD:294511	35/166 (21%)
		vWA_midasin	5261..5526	CDD:238737
Muc68E	NP_996064.1	ChtBD2	<1761..1791	CDD:214696
		ChtBD2	1626..1668	CDD:214696
		ChtBD2	1688..1734	CDD:214696
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	1	0.910