|
Fly 1 MEVNVSKLRLGAQRLLELTANESEDNVFSQSLQKFIKKQKYVPQDVERLFRSLSEQLPLPAYTVP 65
:||..:.|||.|.: ||.. ...|.:|:.||.:.|||.:.:..:|::.|.....||.
Human 6 LEVAAAPLRLIAAK------NEKS----RSELGRFLAKQVWTPQDRQCVLSTLAQLLLDKDCTVL 60
Fly 66 IAASFEEQLLLLL---SMALRWDSASQRFH-TYQLECVALSKLMNFSLDAQRFAKSYFHDKPAPF 126
:.......||.|| :.|:: :..|..| .::..||::|||:....|...||..||.|....|
Human 61 VGRQLRPLLLDLLERNAEAIK--AGGQINHDLHERLCVSMSKLIGNHPDVLPFALRYFKDTSPVF 123
Fly 127 EK--QQSNGSLPSKKSKNGNHAADNLDDLELIKCCFQLLKSDTPYFRELWDWS----------SF 179
:: .:|:.:.|.:..:......| |::..|:.|:.:...|||||||| :.
Human 124 QRLFLESSDANPVRYGRRRMKLRD------LMEAAFKFLQQEQSVFRELWDWSVCVPLLRSHDTL 182
Fly 180 IATYTHNSSSPKTQLYCNYIVAMLTNMSAPQLNSLNEKISTKTRL-EFD---------QEREQAW 234
:..||.| | :|::|.|:.....|..:||.....| .|. |:.|:|.
Human 183 VRWYTAN---------C---LALVTCMNEEHKLSFLKKIFNSDELIHFRLRLLEEAQLQDLEKAL 235
Fly 235 NTARNTLCSYTPDASDQLLNLHL--HGINKSVTNIEGVLLP--------------TFNEENLEFY 283
..|...:..:......|.|..|| ..::..||.:.||:|| :..|:.|...
Human 236 VLANPEVSLWRKQKELQYLQGHLVSSDLSPRVTAVCGVVLPGQLPAPGELGGNRSSSREQELALR 300
Fly 284 ASTDGCYDRIVKVDSTVVNLRSIALGVAAAKPICLSGPVGCGKTTLIEYLARKTGRICPKPNEIE 348
: .|.|:|...:|:::|:.||:...:.|.||:|||||:|:||||..|||
Human 301 S--------YVLVESVCKSLQTLAMAVASQNAVLLEGPIGCGKTSLVEYLAAVTGR--------- 348
Fly 349 SREKALKKAEEEEQLLTPKKKAKTTGSKRKLEEVPLEELLDLGETTKKSGFLRIQLGDQTDSKML 413
||....|::|||||||||||
Human 349 ---------------------------------------------TKPPQLLKVQLGDQTDSKML 368
Fly 414 LGQYRCTDVPGEFVWLPGVLTQAVMHGYWLLLEDLDAATQDTYTILSSLLERQCLSVPGFRDSVK 478
||.||||||||||||.||.||||...|:|:||||:|.|..|..::|..|||...|.:||..|.:|
Human 369 LGMYRCTDVPGEFVWQPGTLTQAATMGHWILLEDIDYAPLDVVSVLIPLLENGELLIPGRGDCLK 433
Fly 479 IEPGFQLFVTVRTNKSASN--SSQKSLYSLLDKYLYTINILPLSRNELCKMVSINYPKLSTVANR 541
:.||||.|.|.|......| ....|..:|||||...|::..|.:.||.:::...||.|..|.:.
Human 434 VAPGFQFFATRRLLSCGGNWYRPLNSHATLLDKYWTKIHLDNLDKRELNEVLQSRYPSLLAVVDH 498
Fly 542 IVDVFLTFSSGNHTSADNLRQQESGDKADNTEQYVALPFEQVPLTSSPN-----SGRLVSTRDLV 601
::|:::..:...|.| ..|.:...|| .| |:|......| .||.:|.|||:
Human 499 LLDIYIQLTGEKHHS--------WSDSSVGCEQ---AP-EEVSEARRENKRPTLEGRELSLRDLL 551
Fly 602 KLCHRSNPQFSVTSSECAYFVFQNAVDVFCSYLPQSKEKVTLITSIGAKLGIIRSRCEHFANEYK 666
..|:|....|..:|...:..:||.|:|.|.:.|.:...|:.:...||:||.|.|.:.|.|...||
Human 552 NWCNRIAHSFDSSSLSASLNIFQEALDCFTAMLSEHTSKLKMAEVIGSKLNISRKKAEFFCQLYK 616
Fly 667 PDVEFGLEHIKIGRASLLAKSDLNNSENEDISEQDLKRQKLSQQTRRAIGKVSNKRTTFSFTRLA 731
|::......:::||..||.| ::|.: .|:|:|. ||:.||.:
Human 617 PEIVINELDLQVGRVRLLRK------QSEAV---HLQREKF----------------TFAATRPS 656
Fly 732 SCILERIAVCVTHSEPVLLVGETGVGKTSSVQYLAERTEHKLVVVNMNNQSDVSDLVGGFKPVEL 796
|.::|::||||:..||||||||||.||||::||||..|.|:|.|||||.|||.:||:||:|||:.
Human 657 SVLIEQLAVCVSKGEPVLLVGETGTGKTSTIQYLAHITGHRLRVVNMNQQSDTADLLGGYKPVDH 721
Fly 797 NYVLAPLRNEFEYLLCETFNQEKNLQFLRLFATHYNSGRHAVIIRTMINICLQVAKNPELKANK- 860
..:..|||..||.|..:||::::|..||....|.|...|...::|.|.:: .:.|.|.:.|.::
Human 722 KLIWLPLREAFEELFAQTFSKKQNFTFLGHIQTCYRQKRWHDLLRLMQHV-HKSAVNKDGKDSET 785
Fly 861 ---LLPRWQTLREKLQKLQMQLDKSIN-ISFAFIPGSLVNCISNGDWVLLDEINLASAETLECLS 921
:..:|:....:|...|.|:..:.| :.|||:.|:|...:..|:|:||||||||:.|.|||||
Human 786 GLLIKEKWEAFGLRLNHAQQQMKMTENTLLFAFVEGTLAQAVKKGEWILLDEINLAAPEILECLS 850
Fly 922 TILE-PEGSVVLLERGDFTPVKRHPDFRIFACMNPNTDIGKKDLPVGIRNRFTEFFVDELTTDAD 985
.:|| ..||:|||:|||..|:.||||||:||||||.||:||::||.||||||||.:|:||.:..|
Human 851 GLLEGSSGSLVLLDRGDTEPLVRHPDFRLFACMNPATDVGKRNLPPGIRNRFTELYVEELESKED 915
Fly 986 LSLLVSDYLANTGIQRKSVHNIVQLYKSLRKLSELQLNDGLGNRPVYSLRTLCRSLRICARNLCG 1050
|.:|:.|||....:.:.:|..|:..|.:|||.|..:|.||.|:||.||||||||:||..|.|.||
Human 916 LQVLIVDYLKGLSVNKNTVQGIINFYTALRKESGTKLVDGTGHRPHYSLRTLCRALRFAASNPCG 980
Fly 1051 SIERNLYESFCLSFLTQLDPNSHHVVLLLI-QNALLSNVKAILSKQLPQ-LGENYLDFEGYWIQP 1113
:|:|:|||.|||.||||||..||.:|..|| |:.:..|||::|.:.:|: .|...:..|||||..
Human 981 NIQRSLYEGFCLGFLTQLDRASHPIVQKLICQHIVPGNVKSLLKQPIPEPKGGRLIQVEGYWIAV 1045
Fly 1114 GNLEPQPCTHYILTESVKKNLKDLARIISIGKLPILLQGPTSAGKTSLIDYVARRSGNRCLRINN 1178
|:.||.....||||.|||.||:|:.|::|.|..|:|:||.||.||||||.::|..:||.|:||||
Human 1046 GDKEPTIDETYILTSSVKLNLRDIVRVVSAGTYPVLIQGETSVGKTSLIQWLAAATGNHCVRINN 1110
Fly 1179 HEHTDLQEYIGTYAADLDGKLTFREGVLVQAMRHGFWIILDELNLASTDILEALNRVLDDNRELY 1243
|||||:|||||.|.:|..|||.|:||||:.|||.|:||||||||||.||:||||||:|||||||.
Human 1111 HEHTDIQEYIGCYTSDSSGKLVFKEGVLIDAMRKGYWIILDELNLAPTDVLEALNRLLDDNRELL 1175
Fly 1244 IAETQTLVKAHPNFMLFATQNPPGLYGGRKTLSRAFKNRFIELHFADIPREELETILEKRCFIPP 1308
:.|||.:|||||.|||||||||||||||||.|||||:|||:||||.::|..||||||.|||.:||
Human 1176 VTETQEVVKAHPRFMLFATQNPPGLYGGRKVLSRAFRNRFVELHFDELPSSELETILHKRCSLPP 1240
Fly 1309 TYARKMVQCMTQLQQHRKNTS----KQVF-TLRDLFRWGNRYTHADKSLHDDNRYDWNQHLVEEG 1368
:|..|:|:.|..||.:|:::| ||.| ||||||||..||..|:.: :..|||.|||..:|
Human 1241 SYCSKLVKVMLDLQSYRRSSSVFAGKQGFITLRDLFRWAERYRLAEPT---EKEYDWLQHLANDG 1302
Fly 1369 YLVLSSKVRSQEEHELIEKTLFANFRKKLDLQTLFDIQTDRESSSMVSRKILDAIRNFKLRDDIV 1433
|::|:.:||.|||.::|::.|..:|:|||..|:||..:...:....:|.:|.....|| ..||
Human 1303 YMLLAGRVRKQEEIDVIQEVLEKHFKKKLCPQSLFSKENVLKLLGKLSTQISTLECNF---GHIV 1364
Fly 1434 WTRNMTRMAVVTAKALEFDEPVLLVGPTGCGKTTVCQLLASIADVQLRILNCHMHTEGADFLGGL 1498
||..|.|:|::..:||||.|||||||.|||||||:||:.|::|:.:|..::||:|.|.:||||||
Human 1365 WTEGMRRLAMLVGRALEFGEPVLLVGDTGCGKTTICQVFAALANQKLYSVSCHLHMETSDFLGGL 1429
Fly 1499 RPCRGK-------ESTQLFEWADGPLIYAMQEGSYFMADEISLAEDSVLERLNCILEPERTVLLA 1556
||.|.| ::::||||.||||:.||:|..:|:.||||||:||||||||.:||.|::::||
Human 1430 RPVRQKPNDKEEIDTSRLFEWHDGPLVQAMKEDGFFLLDEISLADDSVLERLNSVLEVEKSLVLA 1494
Fly 1557 EKGGISELDASPDFVVQAKSGFQFLATMNPGGDFGKKELSPALRNRFTEVWCLPSDNKEDLIE-I 1620
|||...:.|:..:.:...|. |:.|||||||||||||||||||||||||:||..|.::||||: |
Human 1495 EKGSPEDKDSEIELLTAGKK-FRILATMNPGGDFGKKELSPALRNRFTEIWCPQSTSREDLIQII 1558
Fly 1621 AYN-----CMRRQKEHENQAINTHKVAEYLVDVV--LHIRDTNDKFKFSVRDILAWANYM-VSNA 1677
::| |:.|.....:. :.|.::|.: |..::...|...|:||||:|.|:| ....
Human 1559 SHNLRPGLCLGRIDPKGSD------IPEVMLDFIDWLTHQEFGRKCVVSIRDILSWVNFMNKMGE 1617
Fly 1678 KLSFAEQAIFGLETIFLDALEMLPHESQEQVELLKSNIVKQAIKQASLILQE--KFTLEELSE-K 1739
:.:.....|....|.|:.|..:: .::.:.|.:.......|.|..:| ||.::.|:: .
Human 1618 EAALKRPEIISTVTSFVHAACLV------YIDGIGSGVTSSGFGTALLARKECLKFLIKRLAKIV 1676
Fly 1740 RGTEVELNECR----------------FGIRPFFIDVNQERLTSAKEDFLFDAPTTKQNLFRLLS 1788
|.||.:.||.: :||.||||........:...|:...|.||..|..|||.
Human 1677 RLTEYQKNELKIYDRMKAKEFTGIDNLWGIHPFFIPRGPVLHRNNIADYALSAGTTAMNAQRLLR 1741
Fly 1789 ALSLQKPVLLEGPPGVGKTSIVESIGSAIGYQIVRINLCEHTDLADLFGTDLPAEDNLLESNTAA 1853
|..|:||:||||.|||||||:|.::..|.|..:|||||.|.||:.||||.|||.|..
Human 1742 ATKLKKPILLEGSPGVGKTSLVGALAKASGNTLVRINLSEQTDITDLFGADLPVEGG-------- 1798
Fly 1854 TERQIRSFVWRDGPLLAALKAKNTWILLDELNLAPQSVLEGLNAVLDHRGEVYIPELNKSFHLA- 1917
:...|.||||||||||||.: |::|||||||.|||||||||..|||||:|:|||..||.:.
Human 1799 ---KGGEFAWRDGPLLAALKAGH-WVVLDELNLASQSVLEGLNACFDHRGEIYVPELGMSFQVQH 1859
Fly 1918 GSTRIFACQNPLKQGGGRKGLPQSFLNRFTKVYLRKLSTEDLLHVVTEKYGKYFDQLNAYFLELL 1982
..|:||.||||.:|||||||||:|||||||:|::..|:..|: .:....|
Human 1860 EKTKIFGCQNPFRQGGGRKGLPRSFLNRFTQVFVDPLTVIDM----------------EFIASTL 1908
Fly 1983 DQKAEGNLFEIYSGKESSCKSDSFDLGARLVRFSEQLDRGV-ASMEFGYKGGPYEFNLRDILRWC 2046
....|.|:.: ::|.|:.|:|..| ...::|.||||:||||||:.|||
Human 1909 FPAIEKNIVK------------------KMVAFNNQIDHEVTVEKKWGQKGGPWEFNLRDLFRWC 1955
Fly 2047 DLLHNPQTGYILGASPSSFQAAFKDFLLTLYERMQLVYYQRMRCDQDKSYIRNVFSTVFLCDAE- 2110
.|: ::..||..:... :.:.|||.:|||.::||..:..||..||..::.
Human 1956 QLM-------LVDQSPGCYDPG---------QHVFLVYGERMRTEEDKKKVIAVFKDVFGSNSNP 2004
Fly 2111 YLNQVSNDVALYWTADKVYLNDVVLSRKQADVLDLVNRQEQSPLLLDSQR-QQLKQIIETVHMEK 2174
|:......:..| .|.|...||||... |....:.||||..|. |.|:.|::.|.|..
Human 2005 YMGTRLFRITPY----DVQLGYSVLSRGSC-----VPHPSRHPLLLLHQSFQPLESIMKCVQMSW 2060
Fly 2175 PLLLCGSTDSGKTKLIDALCVLSNR-----LCNTDIIDDSVTGSFQQIDLNRHLEIIYKKVETLV 2234
.::|.|....|||.|:..|..|:.. ..|:.:....:.|.|:|:||.|....:.:|||..|
Human 2061 MVILVGPASVGKTSLVQLLAHLTGHTLKIMAMNSAMDTTELLGGFEQVDLIRPWRRLLEKVEGTV 2125
Fly 2235 FSCVQRAFVLHT-QSEFVEQLWNNWSMYNKLAKVTTEAQQHSVLDELKLFSERLGSLGKIIEVLE 2298
.:.::.:.::.. .:|.|.:.|:::.:..| .:.||..||.|
Human 2126 RALLRDSLLISADDAEVVLRAWSHFLLTYK--------------------PKCLGEGGKAI---- 2166
Fly 2299 ATPQNCQVRALQQLAEIKSQLLLLQ-------TYIKT---------------ADSLNTG---GSF 2338
.::.:.::::.|||:| :|.|. ...|.:| |:|
Human 2167 ---------TMEIVNKLEAVLLLMQRLNNKINSYCKAEFAKLVEEFRSFGVKLTQLASGHSHGTF 2222
Fly 2339 EWVDSQIVTSLKCGQYILLEHVNLCSSAVLDRLNPVFEPNGSLLIAEKGISAQDSAEVVYKSTNF 2403
|||||.:|.:||.|.::|:::||.|:.:||||||.:.||.|.|.|:|:|: ...|...:..:.||
Human 2223 EWVDSMLVQALKSGDWLLMDNVNFCNPSVLDRLNALLEPGGVLTISERGM-IDGSTPTITPNPNF 2286
Fly 2404 RAFLTVDPKNGELSRAMRNRCVELSLS--RDTYSVD--DLRAFVHEQGVREMEAIDCILRVH-KG 2463
|.||::||.:|::|||||||.:|:.:| .|..:.| ||:..:|..|:......|.:|.:| :.
Human 2287 RLFLSMDPVHGDISRAMRNRGLEIYISGEGDASTPDNLDLKVLLHSLGLVGNSVCDILLALHTET 2351
Fly 2464 LSQLTEFNNYSISHLTQFAFLSAAYRRIGYELKRAIYVAAMEVYVYS----ANTDLMGYGLSYYQ 2524
.|.:......|:|.|.|.|.|...|.:.|..|.||...|..||||.| ||..|:...|..:.
Human 2352 RSTVVGSPTSSVSTLIQTAILIVQYLQRGLSLDRAFSEACWEVYVCSQHSPANRKLVQALLEKHV 2416
Fly 2525 NKLR------EVVLAQ----TEVFEEVAVIQEDFLSDV---------ILNSGNLNSLTLIKRQAV 2570
:.|| :.:|.. ..|...:...::..||.| .||..::.:.:..:.|..
Human 2417 SSLRAHETWGDSILGMGLWPDSVPSALFATEDSHLSTVRRDGQILVYCLNRMSMKTSSWTRSQPF 2481
Fly 2571 ALKVLLDGYTEGKIPQKLLASLFHEME----------------KLKLDQ-RNPQKLIR-HFLYML 2617
.|:. |:...:...|:.| .|:.:| ||.::: .|...::| .:||.|
Human 2482 TLQD-LEKIMQSPSPENL---KFNAVEVNTYWIDEPDVLVMAVKLLIERATNQDWMLRVKWLYHL 2542
Fly 2618 YESSAIGDLELRHLYLQPWLSKDTAFQELS-----QNLYNCLQKRSNTDTGTLANLP-WNRKLIP 2676
.::...| ||...::|:...:....|...| .|::..||. :.||...:...| ||.:.:.
Human 2543 AKNIPQG-LESIQIHLEASAASLRNFYSHSLSGAVSNVFKILQP-NTTDEFVIPLDPRWNMQALD 2605
Fly 2677 RLRDYSTAESNSELNPLNLSALLLARLVVDIIPVSSVTTV-QQMNALQYSQALCKKQV------- 2733
.:|:....:..:: .|..|.|||.:.....||.:.....| .:.|.:.......::.|
Human 2606 MIRNLMDFDPQTD-QPDQLFALLESAANKTIIYLDREKRVFTEANLVSVGSKKLRESVLRMSFEF 2669
Fly 2734 ---TEKY---ANHLLANFSSFLEVLHTSLLEDLETAD--LDLPQYAHLVTRFHWFNRILATAQQK 2790
.|.| .:.::.|.::|.|:....:|..::::. :.......::....|.:|....|.
Human 2670 HQDPESYHTLPHEIVVNLAAFFELCDALVLLWVQSSQGMVSDASANEILGSLRWRDRFWTVAD-- 2732
Fly 2791 LLYNNELHVPLMHKLVLHFQWLEKHLLVPLIELTAKSGCARMLTIQDRTLK-------------- 2841
..::..|.:..|.||:.|:.|||:..:..| ::..:|:..|
Human 2733 ---TVKVDAPGLALLALHWHWVLKHLVHQIPRL--------LMNYEDKYYKEVQTVSEHIQNCLG 2786
Fly 2842 --------IKKYIEETRRPLNVTCKIYSKQFTQFQPYYQDQQIQRHIELDDLEKLLSVVPSYGNL 2898
|||..:...||.....|:..:.|:| |..|.|:|::......|
Human 2787 SQTGGFAGIKKLQKFLGRPFPFKDKLVVECFSQ---------------LKVLNKVLAIREQMSAL 2836
Fly 2899 ELSSWLKRWLLLQTDDANKWRSFLRKHTNGFQPKAFEISGSLRNETLQSHLQKLQTTLKEAQENS 2963
..|.|.:....||. .|::| :|:...||:....|:..:.|
Human 2837 GESGWQEDINRLQV-VASQW--------------------TLKKSLLQAWGLILRANILE----- 2875
Fly 2964 AEIEMD----------LELDLNSIKT-LLEAETEESESYIHPD---GIPTNTPKLLIAALREL-- 3012
::.:| |||....:.. .||.:.:|:.|..||| .|.......|..|:..|
Human 2876 -DVSLDELKNFVHAQCLELKAKGLSLGFLEKKHDEASSLSHPDLTSVIHLTRSVQLWPAMEYLAM 2939
Fly 3013 ---------FMERLLTGTLRDDFDEQVN--------------PLYADQLLTLNSNLWHCLKTLES 3054
||.:........:...|:| |:...:|..|.|.|.| :.
Human 2940 LWRYKVTADFMAQACLRRCSKNQQPQINEEISHLISFCLYHTPVTPQELRDLWSLLHH-----QK 2999
Fly 3055 ANRTEITNAWIELKNEV------NELQNYDEFAVLLEKIGGGYKGLRSYQRQYRNSVQCYQLENL 3113
.:..|||:.|.||.|.: :.:....|:.::...:.| ..||:...||
Human 3000 VSPEEITSLWSELFNSMFMSFWSSTVTTNPEYWLMWNPLPG------MQQREAPKSV-------- 3050
Fly 3114 STRLD-CVQGPSEEGSTDISSQFCYR--------GP-ALSGV-ILSLICQPNGQLRSVPLSELLE 3167
|| .::||... :..|.|:.|:. .| .:||: ||| ...|.|.|.:|
Human 3051 ---LDSTLKGPGNL-NRPIFSKCCFEVLTSSWRASPWDVSGLPILS--------SSHVTLGEWVE 3103
Fly 3168 WRSALQQTRHLIWENSQLLTSRYSGEVNNLLQAKENARQL--LKEL-------EYVRKLSEKEQK 3223
....||....::|.|..:.:.......::.||.:...|.| |.|| ||::...:....
Human 3104 RTQQLQDISSMLWTNMAISSVAEFRRTDSQLQGQVLFRHLAGLAELLPESRRQEYMQNCEQLLLG 3168
Fly 3224 ANQGFENCAKELEKMI--EKLEK---------------EENNNASMTKDFEVSLTNALVGAIELC 3271
::|.|::..:.|..|. |.|.| |..:..|:.:..:.......:|.:::.
Human 3169 SSQAFQHVGQTLGDMAGQEVLPKELLCQLLTSLHHFVGEGESKRSLPEPAQRGSLWVSLGLLQIQ 3233
Fly 3272 LLTNTPLIDPVEKNRLKNEYIAEDIDCL----------STLTTAYDFM-KIAMKYRHFGEEIYSE 3325
........||..|...|..|:.|::..| |.|.|..|.. ::.:.|.| ..
Human 3234 TWLPQARFDPAVKREYKLNYVKEELHQLQCEWKTRNLSSQLQTGRDLEDEVVVSYSH------PH 3292
Fly 3326 LELRLRTALQRQQQLS----QKLALRSEKCLYASLVQDITHFLHSNGDCESLYKLFQLIHSEWEN 3386
:.| ||..:.|...|: :|.|.|.:...|.||||:|.|::.|.....::..|...:
Human 3293 VRL-LRQRMDRLDNLTCHLLKKQAFRPQLPAYESLVQEIHHYVTSIAKAPAVQDLLTRL------ 3350
Fly 3387 FQGLHV--ATSAQLKSSIEVLGKLDLWLANAQRFVHHTLSRYSAYYQDFVEPIKCSVNQLRFGLE 3449
.|.||: ..|||:..|: |.:...|..:..:| ...||....:|.|.|.|::.|:.||:.|
Human 3351 LQALHIDGPRSAQVAQSL--LKEEASWQQSHHQF-RKRLSEEYTFYPDAVSPLQASILQLQHG-- 3410
Fly 3450 SLKVIFTRVQQA--GSVSQAEQMQQTIGDIVQFPSQHPLV------------IRNSRLYGLLAEL 3500
::::.:.:..: .|:..|:::......::.|||..|.. :::..:...|.:|
Human 3411 -MRLVASELHTSLHSSMVGADRLGTLATALLAFPSVGPTFPTYYAHADTLCSVKSEEVLRGLGKL 3474
Fly 3501 ------------------PHSEYEYFRLLKAKLSELSNYIALGRVIDETTFAAYDDALSICNQTW 3547
|..| :||...|..|.:::.....:|:.....:..........|
Human 3475 ILKRSGGKELEGKGQKACPTRE----QLLMNALLYLRSHVLCKGELDQRALQLFRHVCQEIISEW 3535
Fly 3548 QQEEHRRCQLKAEAES-LYVTKTKGG--VDSEELIEMQEIEHNFPTNLDEDFAEFVSQPTLEQVL 3609
.::| |..|.|||.|| ||..:::.. ..|||..|.:|....||.: ::|||:.:.|||||
Human 3536 DEQE-RIAQEKAEQESGLYRYRSRNSRTALSEEEEEEREFRKQFPLH-EKDFADILVQPTLE--- 3595
Fly 3610 KLDKKASAKDKQSQIVVEEDYAFLARNFID-VMTRHTQ--------VYYKE--QPKSSKELELHL 3663
:.|.::..::.: ...:.|.|::|.:. ||..|.| ::|:: .|..:| |.
Human 3596 --ENKGTSDGQEEE--AGTNPALLSQNSMQAVMLIHQQLCLNFARSLWYQQTLPPHEAK----HY 3652
Fly 3664 LAPYQARFQVFANLHGHYKTALGSSLEER-------AC---NGLAFGLALQQKQLRDIELEEGVS 3718
|:.:.:.:|..|:|..|:...:|..|.:| || :...||.|.....:: .
Human 3653 LSLFLSCYQTGASLVTHFYPLMGVELNDRLLGSQLLACTLSHNTLFGEAPSDLMVK--------P 3709
Fly 3719 SSPYDFYKDSNISEIQSCLDVMERIEKRVLEQLEQYPEHAGLADIKLVISRIRRLPAHAPVVRFN 3783
..|||||:..|:.|.:.|..|::...:.|...|:.:|||..|..:.:|:.|||..|..:|:.:|.
Human 3710 DGPYDFYQHPNVPEARQCQPVLQGFSEAVSHLLQDWPEHPALEQLLVVMDRIRSFPLSSPISKFL 3774
Fly 3784 TGFQLLRQKLALWNEVAHRNNNLVSEEIEVAEFVQRWTRLELQHWRNCLGQTAAQVELQAYRYWF 3848
.|.::|..|...|.|.|.|..:|......:::.:.||.:|||..|...|..|..:...::.::||
Human 3775 NGLEILLAKAQDWEENASRALSLRKHLDLISQMIIRWRKLELNCWSMSLDNTMKRHTEKSTKHWF 3839
Fly 3849 FIYNLLQQFIHQKQLDHSYTDIKLAEQRFAQDHLLDAQDLGESQRLELAQVVRILRQFVEASCYG 3913
.||.:|::.: |:|.:....| :::.|..:|..|:.|:|.|..|
Human 3840 SIYQMLEKHM-QEQTEEQEDD----------------------KQMTLMLLVSTLQAFIEGSSLG 3881
Fly 3914 DFHIRLQLLQGFELYLHNVERAGKINGLPPLIAALHNLQLYFSQFAGEIADSAKLRRSPIEKKLK 3978
:||:|||:|..|..: |....::.|...|.:.|.||..|:.||...:.......|||:||:||
Human 3882 EFHVRLQMLLVFHCH---VLLMPQVEGKDSLCSVLWNLYHYYKQFFDRVQAKIVELRSPLEKELK 3943
Fly 3979 EFVKIQSYSKDLSYFSMRNSVASVHRNLNKFLKEY--------RLSIQEKISE-----VFQPKDS 4030
|||||..:: |:|::|::.||...||.|.||:|:: |.|:.|...| :.:|.|.
Human 3944 EFVKISKWN-DVSFWSIKQSVEKTHRTLFKFMKKFEAVLSEPCRSSLVESDKEEQPDFLPRPTDG 4007
Fly 4031 TAKDYTFGTDKGKGLRNYNKIKYLHTERQQFVASEKLLEKFAIQEEFLS-----------DNTLL 4084
.|.:.: .::|.|: ...|.||.:.|..:..:. :..||
Human 4008 AASELS-------SIQNLNR-----------ALRETLLAQPAAGQATIPEWCQGAAPSGLEGELL 4054
Fly 4085 QRLDKHFRTARHVVKETLGQVPYGELITELDDLLASQLERCEHLRSLNVDRSKERPQQKQEAKQI 4149
:||.|..:..|.:....:.:.|...|:..||......:.....|:||.|:.|.|:.:|:.|||.|
Human 4055 RRLPKLRKRMRKMCLTFMKESPLPRLVEGLDQFTGEVISSVSELQSLKVEPSAEKEKQRSEAKHI 4119
Fly 4150 LQQKRKALTDLFKMLHRLGANYKTGLLELSLRNEFEDFQLPPYSIRSMLPRLHPTAQQLDEHL-- 4212
|.||::||:||||.|.::|.:|:.||.....:|..|...|.|..::|.|..:..| |:.|..|
Human 4120 LMQKQRALSDLFKHLAKIGLSYRKGLAWARSKNPQEMLHLHPLDLQSALSIVSST-QEADSRLLT 4183
Fly 4213 ---------DLYYMKSVFKLKLLQNIMLTPLSELGPPNIERIKGFAVDLFLLVQQQREHLSGSTK 4268
..|:.:|:.:...|...:.||..|:|..|:||.:||:..|..::.:||..|:..::
Human 4184 EISSSWDGCQKYFYRSLARHARLNAALATPAKEMGMGNVERCRGFSAHLMKMLVRQRRSLTTLSE 4248
Fly 4269 ELHELRNSLDSLRKLAEII-----------PQADINPSTLNFVKSADIAMEIKQHL-RQIHYVLK 4321
:...|||.|..::::...: ||..:...| |..||| .|...:|:
Human 4249 QWIILRNLLSCVQEIHSRLMGPQAYPVAFPPQDGVQQWT-----------ERLQHLAMQCQILLE 4302
Fly 4322 QWKLLLSCAPSSFIEESENRLLV---------RKISLAQSELHSLCIQILNSS------------ 4365
|...||.|.||.........:.| ....|::.:|..:.:.::.|:
Human 4303 QLSWLLQCCPSVGPAPGHGNVQVLGQPPGPCLEGPELSKGQLCGVVLDLIPSNLSYPSPIPGSQL 4367
Fly 4366 --------------------QELLNELN--NANLEYLSSEKCVTYQKSYAEIQENIKKTLELLR- 4407
.|:|..:. .|:::.:..:.|.|...|:.:. |.....|..|.
Human 4368 PSGCRMRKQDHLWQQSTTRLTEMLKTIKTVKADVDKIRQQSCETLFHSWKDF-EVCSSALSCLSQ 4431
Fly 4408 -----TGQNDYLPLAQPIVELLDS-VQLKNHTEIAPEAIDLANAD-------------------- 4446
.|......|....||..|| :.|....|.....|..|.||
Human 4432 VSVHLQGLESLFILPGMEVEQRDSQMALVESLEYVRGEISKAMADFTTWKTHLLTSDSQGGNQML 4496
Fly 4447 --------TELANIA-HSVLMSMQKIYKHHVKTDEVNQNGEAKEQDEESKEALQEQHLKKCLTGE 4502
:|...|| .::|.::|.:.:...:..|.|.:..:.::|....|.||..||.|.|..:
Human 4497 DEGFVEDFSEQMEIAIRAILCAIQNLEERKNEKAEENTDQASPQEDYAGFERLQSGHLTKLLEDD 4561
Fly 4503 LTSDWQQLSLPRVLGKLSNVL----------LVLKHSHFEGKDKLLCVRRAIGLLPVLEQYQLLA 4557
..:|...|.:.:::..:|.:| ...||..|.....|| :.|:|||..|..|.
Human 4562 FWADVSTLHVQKIISAISELLERLKSYGEDGTAAKHLFFSQSCSLL-----VRLVPVLSSYSDLV 4621
Fly 4558 DYLLLQQLATHKVSAKMLSIVLTVFVEIGSKGFCVPPDLMQDEEGQSKQESKNGEGFGLEDGTGE 4622
.:.|...||||:.:||:||::..||.|:..||||:|.:.|:|..|:...|..:.||.|:.:|.|.
Human 4622 LFFLTMSLATHRSTAKLLSVLAQVFTELAQKGFCLPKEFMEDSAGEGATEFHDYEGGGIGEGEGM 4686
Fly 4623 NDASDKIESEDQLDDAKRPEDRKDEGDKQEPDCK-----EEKGIEMSDDFDAKMQD--VEKPEED 4680
.|.||:|.:|:|::|..: :..|.||::||.| |:..||||:|||.||.| :|:.|||
Human 4687 KDVSDQIGNEEQVEDTFQ---KGQEKDKEDPDSKSDIKGEDNAIEMSEDFDGKMHDGELEEQEED 4748
Fly 4681 DSGESEEEEDLNKEMGETE-EGAEKLDDQIWGDDEEEKPEEEQE-------PDMNEEDQGKGSKD 4737
|.....|..||:|.||:.. |.|:|||:::||||:||:.|||:: |.|:|||....:||
Human 4749 DEKSDSEGGDLDKHMGDLNGEEADKLDERLWGDDDEEEDEEEEDNKTEETGPGMDEEDSELVAKD 4813
Fly 4738 EKDAHNDLDTKN---DAAKEDGKDEHEKDGLDATNEPSGEDKRKEQAKDIDDMKDPEMDEEQTNA 4799
: :||:.| |.:::|.|: ||:..:|.:...||||..|| ||:. :.||.:.:.
Human 4814 D-----NLDSGNSNKDKSQQDKKE--EKEEAEADDGGQGEDKINEQ---IDER---DYDENEVDP 4865
Fly 4800 MHNELEEPPEPEEMDLGDMNNVDE-----GHDDQDEQPTDENPFDIDAMKENMQPAEEPEADGDD 4859
.|...|:.||||.:||.|..|:|. |.|..:|:..:|||.:| .|:||..|
Human 4866 YHGNQEKVPEPEALDLPDDLNLDSEDKNGGEDTDNEEGEEENPLEI---------KEKPEEAG-- 4919
Fly 4860 EHDANEEGDPQSDGSDSEEDEAGTEAKPAEEDHGEGEEATPEDEKDEAETQKRGELEDEDDSKPE 4924
|:|.|.|:.::|.::|:..:...|. |:|:|..|||| |.:|. .|:.|....
Human 4920 -HEAEERGETETDQNESQSPQEPEEG-PSEDDKAEGEE--------EMDTG-----ADDQDGDAA 4969
Fly 4925 DSPEDSKEEKEEKREEKPEEHSQSKDKASKEENVQSMPETDQSSSADQVQQPQDPDIKQDQKLDE 4989
..||:..||:::..|| |||.:.||..::.| |||..|||:.:.::|...:|
Human 4970 QHPEEHSEEQQQSVEE--------KDKEADEEGGENGP-------ADQGFQPQEEEEREDSDTEE 5019
Fly 4990 Q------------------------------------ETGEEKDGVGQAE-NDADDGGHQGVAET 5017
| |.|:|:.|.|.|: |.|: ||:.....
Human 5020 QVPEALERKEHASCGQTGVENMQNTQAMELAGAAPEKEQGKEEHGSGAADANQAE--GHESNFIA 5082
Fly 5018 QETVSQEDRKNERQTQE-KRKQGRTNEERSLGEAEQNKLKQLKTIDQLKDSKESDDAEQEKP--E 5079
|....:..||| ||. |||.|:.:.|||:|:..:...|:|:|:| :|...::.| :
Human 5083 QLASQKHTRKN---TQSFKRKPGQADNERSMGDHNERVHKRLRTVD-------TDSHAEQGPAQQ 5137
Fly 5080 PMDQTE-AEEYQHVKEPKNS-DKTTLDNATEEQSKKIQHQEDEPPNEEEIEAENVDELMEAEE-- 5140
|..|.| |:.::|:|:..:: |..|.|.|::||. |..:|...::||.|.| |.||:.||
Human 5138 PQAQVEDADAFEHIKQGSDAYDAQTYDVASKEQQ---QSAKDSGKDQEEEEIE--DTLMDTEEQE 5197
Fly 5141 --PAVDPE-----------------DDAELEQLGAEKTEQKSDKPSKTEKSKEQLET--PEGMEI 5184
.|.|.| |:.|:| :...|||: |:..:|:|:.::.|. ||
Human 5198 EFKAADVEQLKPEEIKSGTTAPLGFDEMEVE-IQTVKTEE--DQDPRTDKAHKETENEKPE---- 5255
Fly 5185 EGEVVLTMTVPRSSETTAHSNSEILLDK--SSHAEDLSSAEQIELRQQYQKQLTTFRVAQ---PE 5244
||.|:|.|:..:.|:|. ....:|:: ||||:.::||..::..: ||
Human 5256 -----------RSRESTIHTAHQFLMDTIFQPFLKDVN-----ELRQELERQLEMWQPRESGNPE 5304
Fly 5245 HEDY--ETWQGISNRMTQNARELCEQLRLILEPTKCTRLKGDYRTGRRINMKKIIPYIASQFRKD 5307
.|.. |.||.........::.|||:||||||||:..:||||||||:|:|::|:|||||||||||
Human 5305 EEKVAAEMWQSYLILTAPLSQRLCEELRLILEPTQAAKLKGDYRTGKRLNIRKVIPYIASQFRKD 5369
Fly 5308 KIWLRRTKPAQRDYKITIAIDDSKSMHHNNSKTLTLEAISLVSQALTLLESGRLSIVSFGEAPQI 5372
|||||||||::|.|:|.:|||||.||..|::|.|..|:::::..||||||.|::::.||||:.::
Human 5370 KIWLRRTKPSKRQYQICLAIDDSSSMVDNHTKQLAFESLAVIGNALTLLEVGQIAVCSFGESVKL 5434
Fly 5373 ILNHTEQF---DGPRLVNALNFAQDKTKIAGLL----NFIRTANAEESGTGGDNGLFENLLLILS 5430
:....||| .|.:::....|.|.|||||..| |....|.........:.. .|||::|
Human 5435 LHPFHEQFSDYSGSQILRLCKFQQKKTKIAQFLESVANMFAAAQQLSQNISSETA---QLLLVVS 5496
Fly 5431 DGRNIFSEGAQNVKNAIKLARLQRIFLVYIIIDNPDNKNSILDIQHVAVNADGSV-NINSYLDSF 5494
|||.:|.||.:.|..|::.||...||::::::|||.:::|||||:.......|.: .|.||::.|
Human 5497 DGRGLFLEGKERVLAAVQAARNANIFVIFVVLDNPSSRDSILDIKVPIFKGPGEMPEIRSYMEEF 5561
Fly 5495 PFPYYVIVRDLNQLPLVLSEAMRQWFELVNS 5525
|||||:|:||:|.||..||:|:|||||||.:
Human 5562 PFPYYIILRDVNALPETLSDALRQWFELVTA 5592
| 
