DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG13185 and glra4b

DIOPT Version :9

Sequence 1:	NP_001097279.2	Gene:	CG13185 / 36268	FlyBaseID:	FBgn0033661	Length:	5526	Species:	Drosophila melanogaster
Sequence 2:	NP_001189440.1	Gene:	glra4b / 192125	ZFINID:	ZDB-GENE-020402-2	Length:	492	Species:	Danio rerio

Alignment Length:	468	Identity:	81/468 - (17%)
Similarity:	154/468 - (32%)	Gaps:	162/468 - (34%)

- Green bases have known domain annotations that are detailed below.

  Fly   155 LIKCCF-QLLKSDTPYFRE------------LWDWSSFIATYTHNSSSPKTQLYCNYIVAMLTNM 206
            :|:|.| :.|||  |..|.            :...|.:.|....|...|...:.||..:
Zfish    22 VIRCVFSKELKS--PSVRTKPMSPSDFLDKLMGKTSGYDARIRPNFKGPPVNVTCNIFI------ 78

  Fly   207 SAPQLNSLNEKISTKTRLEFDQEREQAWNTARNTLCSYTPDASDQLLNLHLHGINKSVTNIEGVL 271
                 ||......|......:....|.||..|.....|..|:.|         ::.|:  ::.:.
Zfish    79 -----NSFGSITETTMDYRLNVFLRQQWNDPRLAYKEYPDDSLD---------LDPSM--LDSIW 127

  Fly   272 LPTF---NEENLEFY-ASTDGCYDRIVKVDSTVVNLRSIALGVAAAKPICLSG-PVGCGKTTLIE 331
            .|..   ||:...|: .:||   ::::::......|.||.|.:..:.|:.|.. |:.....|:
Zfish   128 KPDLFFANEKGANFHEVTTD---NKLLRIFQNGNVLYSIRLTLILSCPMDLKNFPMDTQTCTM-- 187

  Fly   332 YLARKTGRICPKPNEIES-------------REKALKKAEEEEQLLTPKKKAKTTGSKRKLEEVP 383
                          ::||             .|..::.|::   |:.|              :..
Zfish   188 --------------QLESFGYTMNDLIFQWLDEGPVQVADD---LMLP--------------QFV 221

  Fly   384 LEELLDLGETTKKSGFLRIQLGDQTDSKMLLGQYRCTDVP-------GEF---VWLPGVLTQAVM 438
            |:|..|||..||...               .|::.|.:|.       |.:   :::|.:||..:.
Zfish   222 LKEEKDLGYCTKHYN---------------TGKFTCIEVKFHLERQMGYYLIQMYIPSLLTVILS 271

  Fly   439 H-GYWLLLEDLDAATQDTYTILSSLLERQCLSVPGFRDSVKIEPGFQLFVTVRTNKSASNSSQKS 502
            . .:|:   ::|||                        ..::..|....:|:.|..|.|.:|...
Zfish   272 WVSFWI---NMDAA------------------------PARVGLGITTVLTMTTQSSGSRASLPK 309

  Fly   503 LYSLLDKYLYTINILPLSRNELCKM----VSINYPKLSTVANRIVDVF-----LTFSSGNHTSAD 558
            :     .|:..|:|.    ..:|.:    ..:.|..::.|:.:..:.|     |.....|..::.
Zfish   310 V-----SYVKAIDIW----MAVCLLFVFAALLEYAAVNFVSRQYKEFFRLRRKLRQEQRNRAASG 365

  Fly   559 NLRQQESGDKADN 571
            .....|:.:|::|
Zfish   366 QAGAAETKNKSNN 378

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG13185	NP_001097279.2	MDN1	298..5521	CDD:227596	50/308 (16%)
		P-loop_NTPase	315..505	CDD:304359	34/214 (16%)
		P-loop_NTPase	<887..972	CDD:304359
		P-loop_NTPase	1147..1283	CDD:304359
		P-loop_NTPase	1454..1603	CDD:304359
		P-loop_NTPase	1795..1946	CDD:304359
		P-loop_NTPase	<2335..>2378	CDD:304359
		Prothymosin	4843..4920	CDD:281265
		PHA03151	4856..5060	CDD:177546
		MttA_Hcf106	<5046..5166	CDD:294511
		vWA_midasin	5261..5526	CDD:238737
glra4b	NP_001189440.1	LIC	5..478	CDD:273305	81/468 (17%)
		Neur_chan_LBD	47..253	CDD:280998	47/278 (17%)
		Neur_chan_memb	260..475	CDD:280999	25/155 (16%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.910