DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG13185 and casc-3

DIOPT Version :9

Sequence 1:	NP_001097279.2	Gene:	CG13185 / 36268	FlyBaseID:	FBgn0033661	Length:	5526	Species:	Drosophila melanogaster
Sequence 2:	NP_493346.1	Gene:	casc-3 / 173203	WormBaseID:	WBGene00012343	Length:	584	Species:	Caenorhabditis elegans

Alignment Length:	453	Identity:	94/453 - (20%)
Similarity:	161/453 - (35%)	Gaps:	130/453 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly  4682 SGESEEEEDLNKEMGETEEGAEKLDDQIWGDDEEEKPEEEQEPDMNEEDQGKGSKDEKDAHNDLD 4746
            :.||...|.:.|...|......|::     .:.:..|:|..:|..:.||..:.:..:|.:..|.:
Worm     2 AAESATTETVEKSGNEESTVEVKVN-----GEAQNPPQESAKPAESVEDDDEPAPAKKRSGGDSE 61

  Fly  4747 TKNDAAKEDG-KDEHEKDGLDATNEPSGEDKRKEQAKDIDDMKDPE-MDEEQTNAMHNELEEPPE 4809
            .|.|.|.||| :|..||..||                |..::::|. :.:.....||::...
Worm    62 EKEDEAAEDGPEDGEEKSNLD----------------DDQNVENPAYIPKTGRFYMHDDNRR--- 107

  Fly  4810 PEEMDLGDMNNVDEGHDDQDEQPTDENPFDIDAMKENMQPAEEPEADGDDEHDANEE--GDPQSD 4872
                  ||:||.....||.|:             :.|:   ::..||.|.:||..:|  ..|::.
Worm   108 ------GDVNNSQVQDDDSDD-------------RRNL---KKSRADCDWKHDRFDEKFQRPKTK 150

  Fly  4873 -------GSDSEEDEAGTEAKPAEEDHGEGEEATPEDEKDEAET---QKRGELEDEDDSKPEDSP 4927
                   |.|....: ||..:..||......|:|.|:..|..:.   ||...:......|...|.
Worm   151 KQIVTKYGFDIRHKD-GTPIQDGEEIDAPAPESTEEESSDARQVSRQQKDRRVSSTTRGKVGKSG 214

  Fly  4928 EDSKEEKEEKREEKPEEHSQSKDKASKEENVQSMPETDQSSSADQVQQPQDPDIKQDQKLDEQE- 4991
            ...:..|:.:||:..:|        ||.|.     |.||.     |:..|...:||.:|..:|:
Worm   215 TSRRPMKQREREDTVDE--------SKGEE-----EEDQG-----VRPAQKRQVKQQEKPRKQKP 261

  Fly  4992 ----TGEEKDGVGQAENDADDGGHQGVAETQETVSQEDRKNERQTQEKRK----------QGRTN 5042
                :.||.      |.|.|||.              .|:.:|:....|:          :||.:
Worm   262 AAPPSSEEN------EEDEDDGA--------------IRRGQRRAVPLRRGTTSGPPSRLRGRMS 306

  Fly  5043 E-----ERSLGEAEQNKLKQLKTIDQLKDSKESDDAEQEKPEPMDQTEAEEYQHVKEPKNSDK 5100
            .     .||.|....:          ..:.:..:.:.:..|.|...:...:|.| :..:|.|:
Worm   307 HPMGPPRRSSGAPPSS----------ASNRRPVESSSRGPPPPPSSSSRRDYSH-QGDRNDDR 358

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG13185	NP_001097279.2	MDN1	298..5521	CDD:227596	94/453 (21%)
		P-loop_NTPase	315..505	CDD:304359
		P-loop_NTPase	<887..972	CDD:304359
		P-loop_NTPase	1147..1283	CDD:304359
		P-loop_NTPase	1454..1603	CDD:304359
		P-loop_NTPase	1795..1946	CDD:304359
		P-loop_NTPase	<2335..>2378	CDD:304359
		Prothymosin	4843..4920	CDD:281265	20/88 (23%)
		PHA03151	4856..5060	CDD:177546	51/235 (22%)
		MttA_Hcf106	<5046..5166	CDD:294511	8/55 (15%)
		vWA_midasin	5261..5526	CDD:238737
casc-3	NP_493346.1	Btz	55..165	CDD:214991	33/150 (22%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910