DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG13185 and Gabra4

DIOPT Version :9

Sequence 1:	NP_001097279.2	Gene:	CG13185 / 36268	FlyBaseID:	FBgn0033661	Length:	5526	Species:	Drosophila melanogaster
Sequence 2:	NP_001345970.1	Gene:	Gabra4 / 14397	MGIID:	95616	Length:	578	Species:	Mus musculus

Alignment Length:	460	Identity:	91/460 - (19%)
Similarity:	156/460 - (33%)	Gaps:	154/460 - (33%)

- Green bases have known domain annotations that are detailed below.

  Fly   362 QLLTPKKKAKT---TGSKRKLEEVPLEELLDLGETTKKSGFLRIQLGDQT--DSKMLLGQYRCTD 421
            ::|.|..:.||   ..|...:.:|.:|..:|:        |.|     ||  |.::   :|   |
Mouse    92 EILGPVTEVKTDIYVTSFGPVSDVEMEYTMDV--------FFR-----QTWIDKRL---KY---D 137

  Fly   422 VPGEFVWLPGVLTQAVMHGYWLLLEDLDAATQDTYTILSSLLERQCLSVPGFRDSVKIEPGFQLF 486
            .|.|.:.|..::...|    |         |.||:                ||:..|
Mouse   138 GPIEILRLNNMMVTKV----W---------TPDTF----------------FRNGKK-------- 165

  Fly   487 VTVRTNKSASNSSQKSLYSLL--DKYLYTINILPLSRNELCKMVSINYP--------KLSTVANR 541
             :|..|.:|.|    .|:.::  ...|||:.   |:.:..|.|..:::|        |..:.|..
Mouse   166 -SVSHNMTAPN----KLFRIMRNGTILYTMR---LTISAECPMRLVDFPMDGHACPLKFGSYAYP 222

  Fly   542 IVDVFLTFSSGNHTSADNLRQQESGDKADNTEQYVALPFEQVPLTSSPNSGRLVSTRDLVKLCHR 606
            ..::..|::.|                   .|:.|.:|.|...|......|:.||: :.:|
Mouse   223 KSEMIYTWTKG-------------------PEKSVEVPKESSSLVQYDLIGQTVSS-ETIK---- 263

  Fly   607 SNPQFSVTSS------------ECAYFVFQNAVDVFCSYLP-------------QSKEKVTLITS 646
                 |:|..            :..||:.|       :|:|             .:||.|...|.
Mouse   264 -----SITGEYIVMTVYFHLRRKMGYFMIQ-------TYIPCIMTVILSQVSFWINKESVPARTV 316

  Fly   647 IGAKLGIIRSRCEHFANEYKPDVEFGLE---HIKIGRA----SLLAKSDLNNSENEDISEQDLKR 704
            .|....:..:.....|....|.|.:...   .|.:..|    :|:..:.:|...|..:.:...|.
Mouse   317 FGITTVLTMTTLSISARHSLPKVSYATAMDWFIAVCFAFVFSALIEFAAVNYFTNIQMQKAKKKI 381

  Fly   705 QKLSQQTRRA-IGKVSNKRTTFSFTRLASCILERIAVCVTHSEPVLLVGETGVG----KTSSVQY 764
            .|...:...| :.|..:..|:...|. |:..:.:....:.|||.. :...|.||    |||:||.
Mouse   382 SKPPPEVPAAPVLKEKHTETSLQNTH-ANLNMRKRTNALVHSESD-VKSRTEVGNHSSKTSAVQE 444

  Fly   765 LAERT 769
            .:|.|
Mouse   445 SSEAT 449

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG13185	NP_001097279.2	MDN1	298..5521	CDD:227596	91/460 (20%)
		P-loop_NTPase	315..505	CDD:304359	31/147 (21%)
		P-loop_NTPase	<887..972	CDD:304359
		P-loop_NTPase	1147..1283	CDD:304359
		P-loop_NTPase	1454..1603	CDD:304359
		P-loop_NTPase	1795..1946	CDD:304359
		P-loop_NTPase	<2335..>2378	CDD:304359
		Prothymosin	4843..4920	CDD:281265
		PHA03151	4856..5060	CDD:177546
		MttA_Hcf106	<5046..5166	CDD:294511
		vWA_midasin	5261..5526	CDD:238737
Gabra4	NP_001345970.1	Neur_chan_LBD	13..565	CDD:332142	91/460 (20%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910