DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG13185 and otogl2

DIOPT Version :9

Sequence 1:	NP_001097279.2	Gene:	CG13185 / 36268	FlyBaseID:	FBgn0033661	Length:	5526	Species:	Drosophila melanogaster
Sequence 2:	XP_031761380.1	Gene:	otogl2 / 101733689	XenbaseID:	XB-GENE-6035211	Length:	3475	Species:	Xenopus tropicalis

Alignment Length:	927	Identity:	184/927 - (19%)
Similarity:	330/927 - (35%)	Gaps:	255/927 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly  4619 GTGEND-----ASDKIESEDQLDDAKRPEDRKDEGDKQEPDCKEEKGIEMSDDFDAKMQDVEKPE 4678
            |||..|     .:|||....  |..|        .:.|..:|:..|..:.:.|.:.|::....||
Frog    16 GTGAGDDGDCFYNDKIYKNG--DTVK--------SNCQICECENGKIKDCARDVNCKIKRAVTPE 70

  Fly  4679 EDDSGESEEEEDLNKEMGETEEGAEKLDDQIWGDDEEEKPEEEQEPDMNEEDQGKGSKDEKDAHN 4743
            :|:.                        ..::.||          |.:.|..:|||:...|.|..
Frog    71 QDEV------------------------PIVYDDD----------PSVIESSEGKGNVRAKRAAV 101

  Fly  4744 DLDTKNDAAKEDGKDEHEKDGLDATNEPSGEDKRKEQAKDIDDMKDPEMDEEQTNAMHNELEEPP 4808
            .::.||.||        .|..|..|    |.|:.||..|  .::|:   |:..||
Frog   102 GVNKKNSAA--------TKFSLGIT----GTDEDKEFLK--TNVKN---DKVNTN---------- 139

  Fly  4809 EPEEMDLGDMNNVDEGHDDQDEQPTDENPFDIDAMKENMQPAEEPEADGDDEHDANEEGDPQSDG 4873
                      .|..:||||..:.           .|||.|             :..:|.:.:...
Frog   140 ----------QNQGKGHDDSRKD-----------SKENSQ-------------EKGQENNKKFSK 170

  Fly  4874 SDSEEDEAGTEAKPAEEDHGEGEEATPEDEKDEAETQKRGELEDEDDSKPEDSPEDSKEEKEEKR 4938
            ..|||.:.|::.|...         ...|:.:..:.|.:|    .|||: :||.::|:|:.::..
Frog   171 DSSEEKDDGSKEKWGN---------VKNDKVNTNQNQGKG----HDDSR-KDSKDNSQEKGQQNN 221

  Fly  4939 EEKPEEHSQSKDKASKEENVQSMPETDQSSSADQVQQPQDPDIKQDQKLDEQETGEEKDGVGQAE 5003
            :...::.|:.||.||||::......:.|:|   |.|.....|...:.|  |.:.|:.|:|..:..
Frog   222 KRFSKDSSEEKDNASKEKSTFKKTYSVQTS---QNQGKGHDDSSSESK--ENKKGQNKNGFSKDS 281

  Fly  5004 NDADDGGHQGVAETQETVSQEDRKNERQTQEKRKQGRTNEERSLGEAEQNKLKQLKTIDQLKDSK 5068
            ::..|.|.:..:..::|.|         .|..:.||:.:::.| .|:::||..|.|.......|:
Frog   282 SEEKDDGSKEKSAFKKTYS---------VQTSQNQGKGHDDSS-SESKENKKGQNKNGFSKDSSE 336

  Fly  5069 ESDDAEQEKPEPMDQTEAEEYQHVKEPKNSDKTTLDNATEEQSKKIQHQEDEPPNEEEIEAENVD 5133
            |.||..:||.           .|.|..||.......|..::.||:.:...|....::.......:
Frog   337 EKDDGSKEKS-----------GHGKNDKNKPNINKGNDHDDSSKESKENTDRQKGQKNKNGWLKN 390

  Fly  5134 ELMEAEEPAVDPEDDAELEQLGAEKTEQKSDKPSKTEKSKEQLETPEGMEIEGEVVLTMTVPRSS 5198
            ...|        :||...|:.|..|..:  .|| |..|.|:|          |:         ||
Frog   391 SSHE--------KDDGSKEKEGHWKNGK--GKP-KQNKGKDQ----------GD---------SS 425

  Fly  5199 ETTAHSNSEILLDKSSHAEDLSSAEQIELRQQYQKQLT---TFRVAQPEHEDYET---WQGISNR 5257
            ..:..::.|...:|.|..|.:.:........:....:|   |..|.|...:|..|   .:.:.|.
Frog   426 NESKSNSQEKGQNKDSSVEIVPTVSNENTGDEEDNNVTPSVTPVVEQKRDQDISTDGPEEAVINS 490

  Fly  5258 MTQNARELCEQLRLILEPTKCTRLKGDYRTGRRINMKKIIPYIASQFRKDKIWLRRTKPAQRDY- 5321
            ...|...:.:.....|..:.||..||.....:.:|...:......|..:.........|...:|
Frog   491 CIFNKESIADGETKDLSCSSCTCNKGKLTCMKNLNCPGVCSVTGYQMIRTFDGSLYDSPGTCNYV 555

  Fly  5322 -----KITIAIDDSKSMHHNNSKT----LTLEAISL---VSQALTLLESGRLSIVSFGEAPQI-- 5372
                 ..||::.:......:|..|    :.::.:.:   ...::.:|..|  |::|.|:...:
Frog   556 LVKTSNFTISLSNKPCSGQDNGITNPDAVCIDTVDIYLPTIASIKILPDG--SVLSAGQQVDLPF 618

  Fly  5373 -------ILNHTEQF-DGPRLVNALNFAQDKTKIAGLLNFIRTANAEES----GTGGDNGL---- 5421
                   ||..:..| |   :|..:...|...|...|...::|:..:::    ||..||.|
Frog   619 FIAETITILRSSSTFLD---VVTPMFSLQYDIKGNRLYVIVQTSYKDQTSGLCGTYNDNRLDDFR 680

  Fly  5422 -----FENLLLILSDGRNIFSEGAQNVKNAIKLARLQRIFLVYIIIDNPDNK--------NSILD 5473
                 .|.:..:.|....:.|:.::|||.:                |:|..:        ||:.|
Frog   681 SSSDITETVSSLFSKSWKLQSQCSENVKTS----------------DSPAQRVTADLSCTNSLQD 729

  Fly  5474 IQHVAVNADGSVNINSY 5490
                ::.||.::.|:::
Frog   730 ----SIFADCNLVIDTH 742

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG13185	NP_001097279.2	MDN1	298..5521	CDD:227596	184/927 (20%)
		P-loop_NTPase	315..505	CDD:304359
		P-loop_NTPase	<887..972	CDD:304359
		P-loop_NTPase	1147..1283	CDD:304359
		P-loop_NTPase	1454..1603	CDD:304359
		P-loop_NTPase	1795..1946	CDD:304359
		P-loop_NTPase	<2335..>2378	CDD:304359
		Prothymosin	4843..4920	CDD:281265	13/76 (17%)
		PHA03151	4856..5060	CDD:177546	45/203 (22%)
		MttA_Hcf106	<5046..5166	CDD:294511	26/119 (22%)
		vWA_midasin	5261..5526	CDD:238737	47/274 (17%)
otogl2	XP_031761380.1	elast_bind_EbpS	121..442	CDD:411220	94/439 (21%)
		VWD	520..683	CDD:214566	27/167 (16%)
		TIL	894..953	CDD:396409
		VWD	983..1134	CDD:413350
		C8	1171..1238	CDD:400886
		PHA03247	<2898..3171	CDD:223021
		GHB_like	3354..3436	CDD:419725
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910