DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG13185 and gabra5

DIOPT Version :9

Sequence 1:	NP_001097279.2	Gene:	CG13185 / 36268	FlyBaseID:	FBgn0033661	Length:	5526	Species:	Drosophila melanogaster
Sequence 2:	XP_004911866.1	Gene:	gabra5 / 100494208	XenbaseID:	XB-GENE-980292	Length:	475	Species:	Xenopus tropicalis

Alignment Length:	485	Identity:	96/485 - (19%)
Similarity:	171/485 - (35%)	Gaps:	149/485 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly   195 YCNYIVAMLTNMS------APQLNSLNEKISTKTRLEFDQEREQAWNTARNTLCSYTPDASDQLL 253
            :|.:: |:.||.|      ||.....|:.|:..||:                        .|.||
Frog    22 FCLFL-ALATNFSMSQTTAAPVKEDTNDNITIFTRI------------------------LDGLL 61

  Fly   254 ----NLHLHGINKSVTNIE-GVLLPTF---NEENLEFYASTDGCYDRIVKVDSTVVNLRSIALGV 310
                |....|:.:.:|.:: .:.:.:|   ::..:|:  :.|..:.:..|.:.
Frog    62 DGYDNRLRPGLGERITQVKTDIYVTSFGPVSDTEMEY--TIDVFFRQSWKDER------------ 112

  Fly   311 AAAKPICLSGPVGCGKTTLIEYLARK---------TGRICPKPNEIESREKALKKAEEEEQLLTP 366
                 :|..||:  .:..|...||.|         .|:.....| |.:..|.| :.|::..||..
Frog   113 -----LCFQGPM--PRLPLNNLLASKIWTPDTFFHNGKKSIAHN-ITTPNKLL-RLEDDGTLLYT 168

  Fly   367 KKKAKTTGSKRKLEEVPLEE---LLDLGETTKKSGFLRIQLGDQTDSKML-------LGQYRCTD 421
            .:...:.....:||:.|::.   .|..|.....:..||.:..:.||..::       |.||.
Frog   169 MRLTISAECPMQLEDFPMDAHACPLKFGSYAYPNSELRYEWTNITDKSVVVAEDGSRLNQYH--- 230

  Fly   422 VPGEFVWLPGVLTQ----AVMHGYWLLLEDLDAATQDTY------TILSSL---LERQCLSVPGF 473
            :.|:.|....:.|.    .||..::.|...:......||      .|||.:   |.|:  |||
Frog   231 LIGQTVGTENISTSTGEYTVMTAHFHLKRKIGYFVIQTYLPCIMTVILSQVSFWLNRE--SVP-- 291

  Fly   474 RDSVKIEPGFQLFVTVRT-NKSASNSSQKSLY-SLLDKYLYTINILPLSRNELCKMVSINY---- 532
               .:...|....:|:.| :.||.||..|..| :.:|.::........|  .|.:..::||
Frog   292 ---ARTVFGVTTVLTMTTLSISARNSLPKVAYATAMDWFIAVCYAFVFS--ALIEFATVNYFTKR 351

  Fly   533 -----PKLSTVANRIVDVFLTFSSGNHTSADNLRQQES-GDKADNTEQYVALPFEQVPLTSSPNS 591
                 .|.:..|.:|                ..::||| |.|..|:..      .::|.|  ||
Frog   352 SWAWDGKKALEAAKI----------------KKKEQESLGRKPINSYS------GRIPYT--PN- 391

  Fly   592 GRLVSTRDLVK--LCHRSNPQFSVTSSECA 619
                .::||..  :.:.::.....|..:||
Frog   392 ----MSKDLTSSVIANAASIHMKTTEEKCA 417

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG13185	NP_001097279.2	MDN1	298..5521	CDD:227596	75/368 (20%)
		P-loop_NTPase	315..505	CDD:304359	52/223 (23%)
		P-loop_NTPase	<887..972	CDD:304359
		P-loop_NTPase	1147..1283	CDD:304359
		P-loop_NTPase	1454..1603	CDD:304359
		P-loop_NTPase	1795..1946	CDD:304359
		P-loop_NTPase	<2335..>2378	CDD:304359
		Prothymosin	4843..4920	CDD:281265
		PHA03151	4856..5060	CDD:177546
		MttA_Hcf106	<5046..5166	CDD:294511
		vWA_midasin	5261..5526	CDD:238737
gabra5	XP_004911866.1	LIC	25..452	CDD:273305	95/482 (20%)
		LGIC_ECD_GABAAR_A5	62..260	CDD:349839	40/223 (18%)
		Cys-loop	177..191	CDD:349839	3/13 (23%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910