DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Damm and CFLAR

DIOPT Version :9

Sequence 1:	NP_001303345.1	Gene:	Damm / 36266	FlyBaseID:	FBgn0033659	Length:	255	Species:	Drosophila melanogaster
Sequence 2:	NP_001120655.1	Gene:	CFLAR / 8837	HGNCID:	1876	Length:	480	Species:	Homo sapiens

Alignment Length:	179	Identity:	38/179 - (21%)
Similarity:	67/179 - (37%)	Gaps:	42/179 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly    61 NDVNALRKTFESLKCRVEVISNPALPDVKNKVKEWSAKRFTQD-AGFVLFILSHG--------DR 116
            |:...||.||.||...|:...:.::..:...:.:::.....:| ..||..::|.|        |:
Human   262 NETELLRDTFTSLGYEVQKFLHLSMHGISQILGQFACMPEHRDYDSFVCVLVSRGGSQSVYGVDQ 326

  Fly   117 KEKILACDH-REYHLDDDVLFPLFRNPTLSGKPKILIVQ---ACKGP------LRADAKKMNNEP 171
            ....|...| |...:.|..       |.|:||||:..:|   ..:|.      |..|...|.|..
Human   327 THSGLPLHHIRRMFMGDSC-------PYLAGKPKMFFIQNYVVSEGQLEDSSLLEVDGPAMKNVE 384

  Fly   172 YIK-----C---------YSCSEGYLSYRNENHG--SVFIQTLCEAMDQ 204
            :..     |         :|.....:|...::|.  |:::|.|.:.:.|
Human   385 FKAQKRGLCTVHREADFFWSLCTADMSLLEQSHSSPSLYLQCLSQKLRQ 433

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Damm	NP_001303345.1	Peptidase_C14	42..248	CDD:279049	38/179 (21%)
CFLAR	NP_001120655.1	Not proteolytically processed and involved in apoptosis inhibition	1..435		38/179 (21%)
		Interaction with CASP8 propeptide. /evidence=ECO:0000269\|PubMed:9208847, ECO:0000269\|PubMed:9326610	1..305		8/42 (19%)
		Interaction with FADD. /evidence=ECO:0000269\|PubMed:9208847, ECO:0000269\|PubMed:9326610	1..227
		Interaction with CASP8. /evidence=ECO:0000269\|PubMed:9208847, ECO:0000269\|PubMed:9326610	1..195
		DED_c-FLIP_r1	1..80	CDD:260044
		DED_c-FLIP_r2	91..171	CDD:260046
		Interaction with TRAF1 and TRAF2. /evidence=ECO:0000269\|PubMed:9208847	192..480		38/179 (21%)
		Interaction with CASP3. /evidence=ECO:0000269\|PubMed:9208847, ECO:0000269\|PubMed:9326610	192..435		38/179 (21%)
		Interaction with CASP8 subunits p18 and p10. /evidence=ECO:0000269\|PubMed:9208847, ECO:0000269\|PubMed:9326610	217..480		38/179 (21%)
		CASc	244..479	CDD:214521	38/179 (21%)
		Caspase	263..358		23/101 (23%)
		Interaction with CASP8. /evidence=ECO:0000269\|PubMed:9208847, ECO:0000269\|PubMed:9326610	370..480		12/64 (19%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3573
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810