DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Damm and CASP8

DIOPT Version :9

Sequence 1:	NP_001303345.1	Gene:	Damm / 36266	FlyBaseID:	FBgn0033659	Length:	255	Species:	Drosophila melanogaster
Sequence 2:	NP_001073594.1	Gene:	CASP8 / 841	HGNCID:	1509	Length:	538	Species:	Homo sapiens

Alignment Length:	261	Identity:	71/261 - (27%)
Similarity:	112/261 - (42%)	Gaps:	48/261 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly    17 DSNRVNAEPGQGLDLNEKLK-PPAVYIL---NH------EQFPQ-DSQLNRKGSSNDVNALRKTF 70
            ||.|......|.||...::| .|..|.|   ||      |:.|: .|..:|.|:..|..||..||
Human   269 DSPREQDSESQTLDKVYQMKSKPRGYCLIINNHNFAKAREKVPKLHSIRDRNGTHLDAGALTTTF 333

  Fly    71 ESLKCRVEVISNPALPDVKNKVKEWSAKRFTQDAGFVLFILSHGDRKEKILACDHRE---YHLDD 132
            |.|...::...:..:..:...:|.:.....:....|:..|||||| |..|...|.:|   |.|..
Human   334 EELHFEIKPHDDCTVEQIYEILKIYQLMDHSNMDCFICCILSHGD-KGIIYGTDGQEAPIYELTS 397

  Fly   133 DVLFPLFRNPTLSGKPKILIVQACKG-------PLRADAKKMNNEPYIKCYSCS----------- 179
            .  |...:.|:|:||||:..:|||:|       |:..|:::   :||::....|
Human   398 Q--FTGLKCPSLAGKPKVFFIQACQGDNYQKGIPVETDSEE---QPYLEMDLSSPQTRYIPDEAD 457

  Fly   180 --------EGYLSYRNENHGSVFIQTLCEAM-DQYGLTRDFQSIFKHVKAEVERRSTMTG-SKQV 234
                    ...:||||...|:.:||:||::: ::.....|..:|...|..||..:..... .||:
Human   458 FLLGMATVNNCVSYRNPAEGTWYIQSLCQSLRERCPRGDDILTILTEVNYEVSNKDDKKNMGKQM 522

  Fly   235 P 235
            |
Human   523 P 523

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Damm	NP_001303345.1	Peptidase_C14	42..248	CDD:279049	62/235 (26%)
CASP8	NP_001073594.1	DED_Caspase_8_r1	62..143	CDD:260041
		DD	157..239	CDD:301326
		CASc	284..536	CDD:237997	65/246 (26%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3573
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810