Protein Alignment Damm and CASP4

DIOPT Version :9

• Sequence 1: NP_001303345.1
• Gene: Damm / 36266
• FlyBaseID: FBgn0033659
• Length: 255
• Species: Drosophila melanogaster
• Sequence 2: NP_001216.1
• Gene: CASP4 / 837
• HGNCID: 1505
• Length: 377
• Species: Homo sapiens
• Alignment Length: 339
• Identity: 75/339 - (22%)
• Similarity: 126/339 - (37%)
• Gaps: 96/339 - (28%)

  Fly     2 YLPERTEHQKIERLYDS-----------------NRVNAEPGQGLDLNEKLKPP-------AVYI 42
            |...:|| .|:..:.||                 |.....|.:....|.:..||       |:.:
Human    45 YYDAKTE-DKVRVMADSMQEKQRMAGQMLLQTFFNIDQISPNKKAHPNMEAGPPESGESTDALKL 108

  Fly    43 LNHEQF------------PQDSQLN------------------RKGSSNDVNALRKTFESLKCRV 77
            ..||:|            |...:.|                  |.|:..|:..:::..|.|...|
Human   109 CPHEEFLRLCKERAEEIYPIKERNNRTRLALIICNTEFDHLPPRNGADFDITGMKELLEGLDYSV 173

  Fly    78 EVISNPALPDVKNKVKEWSAK--RFTQDAGFVLFILSHGDRKEKILACDHREYHLD---DDVLFP 137
            :|..|....|:::.::.::.:  ..:.|:.| |.::||| ..|.|....|.|...|   .|.:|.
Human   174 DVEENLTARDMESALRAFATRPEHKSSDSTF-LVLMSHG-ILEGICGTVHDEKKPDVLLYDTIFQ 236

  Fly   138 LFRNP---TLSGKPKILIVQACKGPLRAD------------AKKMNNE--------------PYI 173
            :|.|.   :|..|||::|||||:|..|.:            |...::|              .:|
Human   237 IFNNRNCLSLKDKPKVIIVQACRGANRGELWVRDSPASLEVASSQSSENLEEDAVYKTHVEKDFI 301

  Fly   174 KCYSCSEGYLSYRNENHGSVFIQTLCEAMDQYGLTRDFQSIFKHVKAEVERRSTMTGSKQVPSEE 238
            ...|.:...:|:|:...||:||..|.....:|......:.:|:.|:...|   |.....|:|:.|
Human   302 AFCSSTPHNVSWRDSTMGSIFITQLITCFQKYSWCCHLEEVFRKVQQSFE---TPRAKAQMPTIE 363

  Fly   239 SHNFDKPFYF--GN 250
            ..:..:.||.  ||
Human   364 RLSMTRYFYLFPGN 377

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Damm	NP_001303345.1	Peptidase_C14	42..248	CDD:279049	60/269 (22%)
CASP4	NP_001216.1	Required for LPS-binding. /evidence=ECO:0000250|UniProtKB:P70343	1..59		4/14 (29%)
		CARD_CASP1-like	5..81	CDD:260036	7/36 (19%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	84..104		4/19 (21%)
		CASc	126..375	CDD:214521	58/253 (23%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3573
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810