DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Damm and Casp2

DIOPT Version :9

Sequence 1:	NP_001303345.1	Gene:	Damm / 36266	FlyBaseID:	FBgn0033659	Length:	255	Species:	Drosophila melanogaster
Sequence 2:	XP_038964243.1	Gene:	Casp2 / 64314	RGDID:	69274	Length:	470	Species:	Rattus norvegicus

Alignment Length:	274	Identity:	59/274 - (21%)
Similarity:	100/274 - (36%)	Gaps:	74/274 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly    20 RVNAEPGQGLDLNEKLKPPAVYILNHEQFPQDSQLN-RKGSSNDVNALRKTFESLKCRVEVISN- 82
            |:.::| :||.|          ::::..|..:..|. |.|...|...|...|:.|...|.|:.:
  Rat   193 RLQSQP-RGLAL----------VMSNVHFTGEKDLEFRSGGDVDHTTLVTLFKLLGYNVHVLYDQ 246

  Fly    83 -----------------PALPDVKNKVKEWS---AKRFTQDAGFVLFILSHGDRKEKILACDHRE 127
                             |...:::.|::.::   |.|.|...  ::.:|||| .:..|...|.:.
  Rat   247 TAQFHRFQLYSGIYKKYPKGQEMQEKLQNFAQLPAHRVTDSC--IVALLSHG-VEGGIYGVDGKL 308

  Fly   128 YHLDDDVLFPLFRN---PTLSGKPKILIVQACKGPL------RADAKKMNNEP------------ 171
            ..|.:  :|.||.|   |:|..|||:..:|||:|..      :.|.|.....|
  Rat   309 LQLQE--VFRLFDNANCPSLQNKPKMFFIQACRGDETDRGVDQQDGKNHAQSPGCEESDAGKEEL 371

  Fly   172 ----------YIKCYSCSEGYLSYRNENHGSVFIQTLCEAMDQYGLTRDFQSIFKHVKAEVERRS 226
                      .|..|:|.:|..:.||...||.:|:.|.:...:.........:...|.|.::.|
  Rat   372 MKMRLPTRSDMICGYACLKGNAAMRNTKRGSWYIEALTQVFSERACDMHVADMLVKVNALIKER- 435

  Fly   227 TMTGSKQVPSEESH 240
                ....|..|.|
  Rat   436 ----EGYAPGTEFH 445

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Damm	NP_001303345.1	Peptidase_C14	42..248	CDD:279049	54/252 (21%)
Casp2	XP_038964243.1	CARD_CASP2	32..118	CDD:260040
Casp2	XP_038964243.1	CASc	192..465	CDD:214521	59/274 (22%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3573
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810