DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Damm and Casp4

DIOPT Version :9

Sequence 1:	NP_001303345.1	Gene:	Damm / 36266	FlyBaseID:	FBgn0033659	Length:	255	Species:	Drosophila melanogaster
Sequence 2:	NP_031635.2	Gene:	Casp4 / 12363	MGIID:	107700	Length:	373	Species:	Mus musculus

Alignment Length:	286	Identity:	71/286 - (24%)
Similarity:	120/286 - (41%)	Gaps:	58/286 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 PE---RTEHQKIERLYDSNRVNAEPGQGLDLNEKLKPPAVYILNHEQFPQDSQLNRKGSSNDVNA 65
            ||   |...:|.:.:|.....|....:.|            |:.:.:|...|.  |.|::.|:..
Mouse   107 PEEFTRLCREKTQEIYPIKEANGRTRKAL------------IICNTEFKHLSL--RYGANFDIIG 157

  Fly    66 LRKTFESLKCRVEVISNPALPDVKNKVKEWSA--KRFTQDAGFVLFILSHGDRKEKILACDHREY 128
            ::...|.|...|.|........:::::|:::|  :..|.|:.| |.::||| ....|....|.|.
Mouse   158 MKGLLEDLGYDVVVKEELTAEGMESEMKDFAALSEHQTSDSTF-LVLMSHG-TLHGICGTMHSEK 220

  Fly   129 H---LDDDVLFPLFRN---PTLSGKPKILIVQACKG------------------------PLRAD 163
            .   |..|.::.:|.|   |.|..|||::|||||:|                        .:.||
Mouse   221 TPDVLQYDTIYQIFNNCHCPGLRDKPKVIIVQACRGGNSGEMWIRESSKPQLCRGVDLPRNMEAD 285

  Fly   164 AKKMNN--EPYIKCYSCSEGYLSYRNENHGSVFIQTLCEAMDQYGLTRDFQSIFKHVKAEVERRS 226
            |.|:::  :.:|..||.:..:||||::..||.||..|.....::..:.....||..|:...|:.|
Mouse   286 AVKLSHVEKDFIAFYSTTPHHLSYRDKTGGSYFITRLISCFRKHACSCHLFDIFLKVQQSFEKAS 350

  Fly   227 TMTGSKQVPSEESHNFDKPFYF--GN 250
            .   ..|:|:.:.....:.||.  ||
Mouse   351 I---HSQMPTIDRATLTRYFYLFPGN 373

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Damm	NP_001303345.1	Peptidase_C14	42..248	CDD:279049	61/239 (26%)
Casp4	NP_031635.2	Required for LPS-binding. /evidence=ECO:0000269\|PubMed:25119034	1..59
		CARD_CASP1-like	5..85	CDD:260036
		CASc	122..371	CDD:214521	65/267 (24%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3573
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810