DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Damm and Casp4

DIOPT Version :9

Sequence 1:	NP_001303345.1	Gene:	Damm / 36266	FlyBaseID:	FBgn0033659	Length:	255	Species:	Drosophila melanogaster
Sequence 2:	NP_446188.2	Gene:	Casp4 / 114555	RGDID:	621757	Length:	373	Species:	Rattus norvegicus

Alignment Length:	277	Identity:	67/277 - (24%)
Similarity:	119/277 - (42%)	Gaps:	55/277 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly    10 QKIERLYDSNRVNAEPGQGLDLNEKLKPPAVYILNHEQFPQDSQLNRKGSSNDVNALRKTFESLK 74
            :|.:.:|.....|....:.|            |:.:.:|...|.  |.|::.|::.::...|.|.
  Rat   116 EKKQEIYPIKETNGRTRKAL------------IICNTEFKHLSL--RYGANIDISGMKGLLEELG 166

  Fly    75 CRVEVISNPALPDVKNKVKEWSA--KRFTQDAGFVLFILSHGDRKEKILACDHREYHLD---DDV 134
            ..|.|........:::::|:::|  :..|.|:.| |.::||| ..:.:....|.|...|   .|.
  Rat   167 YDVVVKEELTAEGMESEMKDFAALSEHQTSDSTF-LVLMSHG-TLQGLCGTMHSEATPDVLLYDT 229

  Fly   135 LFPLFRN---PTLSGKPKILIVQACKG------------------------PLRADAKKMNN--E 170
            ::.:|.|   |.|..|||::|||||:|                        .:.|||.:|::  :
  Rat   230 IYQIFNNCHCPGLRDKPKVIIVQACRGGNPGEVWIRESSGAHSYRAVDLPRNMEADAVRMSHVEK 294

  Fly   171 PYIKCYSCSEGYLSYRNENHGSVFIQTLCEAMDQYGLTRDFQSIFKHVKAEVERRSTMTGSKQVP 235
            .:|..||.:..:||||::..||.||..|......:..:.....||..|:...|:.|.   :.|:|
  Rat   295 DFIALYSTTPHHLSYRDKTRGSYFISKLISCFRIHACSCHLFDIFLKVQQSFEKASI---NSQMP 356

  Fly   236 SEESHNFDKPFYF--GN 250
            :.:.....:.||.  ||
  Rat   357 TIDRATLTRYFYLFPGN 373

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Damm	NP_001303345.1	Peptidase_C14	42..248	CDD:279049	60/239 (25%)
Casp4	NP_446188.2	CARD_CASP1-like	5..85	CDD:260036
Casp4	NP_446188.2	CASc	122..371	CDD:214521	64/267 (24%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3573
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810