Protein Alignment Sln and SLC16A4

DIOPT Version :9

• Sequence 1: NP_610706.1
• Gene: Sln / 36263
• FlyBaseID: FBgn0033657
• Length: 855
• Species: Drosophila melanogaster
• Sequence 2: NP_004687.1
• Gene: SLC16A4 / 9122
• HGNCID: 10925
• Length: 487
• Species: Homo sapiens
• Alignment Length: 617
• Identity: 125/617 - (20%)
• Similarity: 229/617 - (37%)
• Gaps: 166/617 - (26%)

  Fly   221 PNVEPPDGGYGWFIVFGAFSVQFWVAGLVKSYGVLYVEIMETFPSSTATVASWIPAILSALCLVL 285
            |..:..|||:||.||...|.|..:|.|:.|::.:.:|...|.| ..|:....||.:|:|:|....
Human    10 PYTKTLDGGWGWMIVIHFFLVNVFVMGMTKTFAIFFVVFQEEF-EGTSEQIGWIGSIMSSLRFCA 73

  Fly   286 APLSSALCQRFSCRTVVFVGGIFCAMGMILSYFATSLLHLLLTFGVLTGIGGGLSTTPGIVIVSQ 350
            .||.:.:|.....:|...:|......|.::|.:|||:..|.:|.|:|.|:|.........|:.::
Human    74 GPLVAIICDILGEKTTSILGAFVVTGGYLISSWATSIPFLCVTMGLLPGLGSAFLYQVAAVVTTK 138

  Fly   351 YFDKHRALANGICVSGTAAGSFILPVLIKHLAENCGFHGTILILGGCMLHVCVSATLYRPISAYT 415
            ||.|..||:..|..||... :|:|....|.|.:...:.|.:::.|...|::..|:.|.|||...:
Human   139 YFKKRLALSTAIARSGMGL-TFLLAPFTKFLIDLYDWTGALILFGAIALNLVPSSMLLRPIHIKS 202

  Fly   416 DQDSGQGQEETAKPLNEDINPSTTGILTTSTYLDTCDVGAGHELSDKFIEHLFLEESKNHLNYYA 480
            :.:||                                                :::..:.|:.:.
Human   203 ENNSG------------------------------------------------IKDKGSSLSAHG 219

  Fly   481 SKQPAQDKSAQESDDEVKDIIGETTFIKPMKKVRSSGLLHSVEDLSTDSTWVYRKHSGTDSNR-- 543
            .:..|.:....|:::.                        :::|.:|....:..|:.....|:
Human   220 PEAHATETHCHETEES------------------------TIKDSTTQKAGLPSKNLTVSQNQSE 260

  Fly   544 ----GSRRRRNVFANDEVISKIQAHLEKPLSPPSVVSRGLSKSMEIPTPVSNLSDLKQQPVEQAE 604
                |..|.|.:..:||...|:                 :|.|
Human   261 EFYNGPNRNRLLLKSDEESDKV-----------------ISWS---------------------- 286

  Fly   605 LGILDSQLVESIIDGDGHLAADEDDDDDEERGPRTCCERIEMYLDISLLQDPSFILMCLSVTLMS 669
                                                |:::   .||||.::|.|.:...|..|..
Human   287 ------------------------------------CKQL---FDISLFRNPFFYIFTWSFLLSQ 312

  Fly   670 VGCPYMLYYLPAHVISIGYNKSEAGYLVAISAVLDLIGRLGLGWLCD---LQLFDRKKTY-TLCI 730
            :......::|.|...::|.:..:|.|||:::.:|:.:.::..||:.|   ::.:...|:| .||
Human   313 LAYFIPTFHLVARAKTLGIDIMDASYLVSVAGILETVSQIISGWVADQNWIKKYHYHKSYLILC- 376

  Fly   731 LGAGCAVLTIPFAKTLVLVGLSAAVYGLCLGSWYVLMPVLLADVFGTDRISSSYGLVRMFQSIGA 795
               |...|..|.|.|..|:......:.:..|.:..|:..:|.|:.....::...||...|..:..
Human   377 ---GITNLLAPLATTFPLLMTYTICFAIFAGGYLALILPVLVDLCRNSTVNRFLGLASFFAGMAV 438

  Fly   796 ISVPPLAGLMRDLSGDYEICFYCMGSCMVLGT 827
            :|.||:||.:.|.:..|...||..|.|.:|.:
Human   439 LSGPPIAGWLYDYTQTYNGSFYFSGICYLLSS 470

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Sln	NP_610706.1	MFS	235..>411	CDD:119392	50/175 (29%)
		MFS	<656..827	CDD:119392	44/174 (25%)
		MFS_1	658..>847	CDD:284993	43/174 (25%)
SLC16A4	NP_004687.1	MFS	24..477	CDD:119392	118/603 (20%)
		MFS_1	27..442	CDD:284993	106/570 (19%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	206..250		7/115 (6%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165145588
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG2504
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D916876at2759
OrthoFinder	1	1.000	-	-		FOG0000033
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X70
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	7	6.750