Protein Alignment Sln and SLC16A6

DIOPT Version :10

• Sequence 1: NP_610706.1
• Gene: Sln / 36263
• FlyBaseID: FBgn0033657
• Length: 855
• Species: Drosophila melanogaster
• Sequence 2: XP_024306789.2
• Gene: SLC16A6 / 9120
• HGNCID: 10927
• Length: 542
• Species: Homo sapiens
• Alignment Length: 612
• Identity: 136/612 - (22%)
• Similarity: 241/612 - (39%)
• Gaps: 165/612 - (26%)

  Fly   224 EPPDGGYGWFIVFGAFSVQFWVAGLVKSYGVLYVEIMETFPSSTATVASWIPAILSALCLVLAPL 288
            |.||||:||.:....|.|:.:..|::|::||.:.::|::|..|.:.: |||.:|...:....|||
Human    36 EVPDGGWGWAVAVSFFFVEVFTYGIIKTFGVFFNDLMDSFNESNSRI-SWIISICVFVLTFSAPL 99

  Fly   289 SSALCQRFSCRTVVFVGGIFCAMGMILSYFATSLLHLLLTFGVLTGIGGGLSTTPGIVIVSQYFD 353
            ::.|..||..|.||.:||:..:.||:.:.|:..:.|:.:..|:::|:|...|..|.:.|:||||.
Human   100 ATVLSNRFGHRLVVMLGGLLVSTGMVAASFSQEVSHMYVAIGIISGLGYCFSFLPTVTILSQYFG 164

  Fly   354 KHRALANGICVSGTAAGSFILPVLIKHLAENCGFHGTILILGGCMLHVCVSATLYRPISAYTDQD 418
            |.|::...:..:|.....|.....|..|.|..|:..::|.:|...|::.:...|.|||
Human   165 KRRSIVTAVASTGECFAVFAFAPAIMALKERIGWRYSLLFVGLLQLNIVIFGALLRPI------- 222

  Fly   419 SGQGQEETAKPLNEDINPSTTGILTTSTYLDTCDVGAGHELSDKFIEHLFLEESKNHLNYYASKQ 483
                                                        ||                 :.
Human   223 --------------------------------------------FI-----------------RG 226

  Fly   484 PAQDKSA-QESDDEVKDIIGETTFIKPMKKVRSSGLLHSVEDLSTDSTWVYRKHSGTDSNRGSRR 547
            ||..|.. ||:..|.:       ::...:|.|:|  :.|::             ||.:.....:
Human   227 PASPKIVIQENRKEAQ-------YMLENEKTRTS--IDSID-------------SGVELTTSPK- 268

  Fly   548 RRNVFANDEVISKIQAHLEKPLSPPSVVSRGLSKSMEIPTPVSNLSDLKQQPVEQAELGILDSQL 612
                        .:..|....|.|.:.:.:.|.|:...|:
Human   269 ------------NVPTHTNLELEPKADMQQVLVKTSPRPS------------------------- 296

  Fly   613 VESIIDGDGHLAADEDDDDDEERGPRTCCERIEMYLDISLLQDPSFILMCLSVTLMSVG--CPYM 675
                                |::.|         .||.|:|::.|||...|.....::|  .| .
Human   297 --------------------EKKAP---------LLDFSILKEKSFICYALFGLFATLGFFAP-S 331

  Fly   676 LYYLPAHVISIGYNKSEAGYLVAISAVLDLIGRLGLGWLCDLQLFDRKKTYTLCILGAGCAVLTI 740
            ||.:|.. ||:|.::..|.:|::..|:.::.||:|.|::.:.:...:.....:|::....::...
Human   332 LYIIPLG-ISLGIDQDRAAFLLSTMAIAEVFGRIGAGFVLNREPIRKIYIELICVILLTVSLFAF 395

  Fly   741 PFAKTLVLVGLSAAVYGLCLGSWYVLMPVLLA--DVFGTDRISSSYGLVRMFQSIGAISVPPLAG 803
            .||.....:...:..:|..:|:.......|||  ||.|.:::||:.|:....|||..::.|||||
Human   396 TFATEFWGLMSCSIFFGFMVGTIGGTHIPLLAEDDVVGIEKMSSAAGVYIFIQSIAGLAGPPLAG 460

  Fly   804 LMRDLSGDYEICFYCMGSCMVLGTTPL 830
            |:.|.|..|...||...:.|.|....|
Human   461 LLVDQSKIYSRAFYSCAAGMALAAVCL 487

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Sln	NP_610706.1	MFS_MCT_SLC16	231..>409	CDD:340910	52/177 (29%)
		MFS	<652..834	CDD:475125	51/183 (28%)
SLC16A6	XP_024306789.2	MFS_MCT7	43..491	CDD:340980	131/605 (22%)