DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Sln and ESBP6

DIOPT Version :9

Sequence 1:	NP_610706.1	Gene:	Sln / 36263	FlyBaseID:	FBgn0033657	Length:	855	Species:	Drosophila melanogaster
Sequence 2:	NP_014274.1	Gene:	ESBP6 / 855598	SGDID:	S000005069	Length:	673	Species:	Saccharomyces cerevisiae

Alignment Length:	414	Identity:	95/414 - (22%)
Similarity:	149/414 - (35%)	Gaps:	90/414 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly    55 SGGGVGLECGSLFSVVSAPP---------APLPDIVVPTEMDGKHMESAAFRSGCCSPNASPMRR 110
            |.|.|......:.|:.|:.|         ||:|                      ||...|....
Yeast    12 SSGMVSETSSEVSSINSSQPVSFSKASIAAPVP----------------------CSDLHSTKSN 54

  Fly   111 PATLSLDTQCCPRTLHASLLEHQISELEEDDN----ENLLTVS-------------------SIT 152
            .|:..|...   |||...|  :.|.:..:|||    ||...|:                   |:.
Yeast    55 DASRKLSIS---RTLTNRL--NDIKKAVDDDNLQTEENSADVNKILESRFDVADAIRLQHNESVQ 114

  Fly   153 ARPLIAKSHELRSSRKSGSGSGSGLNTAR-------------SRCVRR----------AKERERD 194
            ::..|..:|...:.....:.|.|..:.:.             |:.:|.          .|:.|..
Yeast   115 SKLNIPVTHTTTAGASLSAPSSSAFSASSIQNDTTEHKASMDSKLMRNRLYPASTKHSGKDLEAQ 179

  Fly   195 RVTVARRSKQVVKDRDSSTTTTESGGPNVEPPDGGYGWFIVFGAFSVQFWVAGLVKSYGV--LYV 257
            .:|.....:..||    ...|.:|.|....||||||||.:.|..|...|...|...|:||  .|.
Yeast   180 GITEFEPDEPTVK----KVFTNKSTGQLELPPDGGYGWVVTFCVFLTMFSTWGCNASFGVDLAYY 240

  Fly   258 EIMETFPSSTATVASWIPAILSALCLVLAPLSSALCQRFSCRTVVFVGGIFCAMGMILSYFATSL 322
            ...:|:|.::....:.|..:...|..:|:||..||.:....||.:..|........:|:.|.|.|
Yeast   241 LNHDTYPGASKYDYALIAGLTVFLGQLLSPLVMALMRIIGLRTTMLFGDAVMLAAYLLASFTTKL 305

  Fly   323 LHLLLTFGVLTGIGGGLSTTPGIVIVSQYFDKHRALANGICVSGTAAGSFILPVLIKHLAENCG- 386
            ..|.:|.|.:.|....|...|...::..:|.|.||:|.|:.:.||.||..:..:....:..:.|
Yeast   306 WQLYVTQGFMVGCSISLIFVPATTVLPGWFLKKRAVAMGVSLLGTGAGGVVYGLATNKMLSDFGN 370

  Fly   387 FHGTILILG-GCMLHVCVSATLYR 409
            ....:.|:| .|.:.|.|:..|.:
Yeast   371 TRWCLRIIGISCSISVLVAIALLK 394

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Sln	NP_610706.1	MFS	235..>411	CDD:119392	47/179 (26%)
		MFS	<656..827	CDD:119392
		MFS_1	658..>847	CDD:284993
ESBP6	NP_014274.1	MFS_MCT_SLC16	212..606	CDD:340910	49/183 (27%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG2504
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000033
OrthoInspector	1	1.000	-	-		mtm13433
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11360
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X70
TreeFam	0	0.000	Not matched by this tool.
	6	5.910