DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Sln and MCH5

DIOPT Version :9

Sequence 1:	NP_610706.1	Gene:	Sln / 36263	FlyBaseID:	FBgn0033657	Length:	855	Species:	Drosophila melanogaster
Sequence 2:	NP_014951.4	Gene:	MCH5 / 854483	SGDID:	S000005833	Length:	521	Species:	Saccharomyces cerevisiae

Alignment Length:	773	Identity:	137/773 - (17%)
Similarity:	234/773 - (30%)	Gaps:	298/773 - (38%)

- Green bases have known domain annotations that are detailed below.

  Fly    79 DIVVPTEMDGKHMESAAFRSGCCSPNASPMRRPATLSLDTQCCPRTLHASLLEHQISELEEDDNE 143
            |.:||.|                  ..:.:|:|   .||..    ::|        .:.|.||.|
Yeast    10 DTIVPEE------------------QTNQLRQP---DLDED----SIH--------YDPEADDLE 41

  Fly   144 NLLTVSSITARPLIAKSHELRSSRKSGSGSGS----GLNTARSRCVRRAKERERDRVTVARRSKQ 204
            :|.|.:|..:..:.||.:..:...| |:...|    |.||:.:.
Yeast    42 SLETTASYASTSVSAKVYTKKEVNK-GTDIESQPHWGENTSSTH--------------------- 84

  Fly   205 VVKDRDSSTTTTESGGPNVEP-PDGGY-GWFIVFGAFSVQFWVAGLVKSYGVLYVEIMET-FPSS 266
               |.|..    |.....:|. |:||: .|.:.||.|.......||:.|.||:...:.:. ..|.
Yeast    85 ---DSDKE----EDSNEEIESFPEGGFKAWVVTFGCFLGLIACFGLLNSTGVIESHLQDNQLSSE 142

  Fly   267 TATVASWIPAILSALCLVLAPLSSALCQRFSCRTVVFVGGIFCAMGMILSYFATSLLHLLLTFGV 331
            :.:...|:.::...:|.....:|.....|...||::.||.:|...|:..:..:|...|.:|:|.:
Yeast   143 SVSTIGWLFSLFLFVCSASCIISGTYFDRNGFRTIMIVGTVFHVAGLFATANSTKYWHFILSFAI 207

  Fly   332 LTGIGGGLSTTPGIVIVSQYFDKHRALANGICVSGTAAGSFILPVLIKHLAENCGFHGTILILGG 396
            :.|.|.|:..:|.:.:.:.||.|.|..|..:...|.:.|..:.|::::..
Yeast   208 VCGFGNGIVLSPLVSVPAHYFFKRRGTALAMATIGGSVGGVVFPIMLRSF--------------- 257

  Fly   397 CMLHVCVSATLYRPISAYTDQDSGQGQEETAKPLNEDINPSTTGILTTSTYLDTCDVGAGHELSD 461
                          .|..:|.|...|              ...||.|.. :||...:.....|..
Yeast   258 --------------FSMKSDTDPTYG--------------FVWGIRTLG-FLDLALLTLSIILVK 293

  Fly   462 KFIEHLFLEESKNHLNYYASKQPAQDKSAQESDDEVKDIIGETTFIKPMKKVRSSGLLHSVEDLS 526
            :.:.|: :|.||:                           ||
Yeast   294 ERLPHV-IENSKD---------------------------GE----------------------- 307

  Fly   527 TDSTWVYRKHSGTDSNRGSRRRRNVFANDEVISKIQAHLEKPLSPPSVVSRGLSKSMEIPTPVSN 591
              |.|.|
Yeast   308 --SRWRY---------------------------------------------------------- 312

  Fly   592 LSDLKQQPVEQAELGILDSQLVESIIDGDGHLAADEDDDDDEERGPRTCCERIEMYLDISLLQDP 656
                           ||...:::                          |...:.:||:.
Yeast   313 ---------------ILRVYILQ--------------------------CFDAKAFLDMK----- 331

  Fly   657 SFILMCLSVTLMS-VGCPYMLYYLPAHVISIGYNKSEAGYLVAISAVLDLIGRLGLGWLCDLQLF 720
              .|.|:..|:.| :.....|.|..::..|.|.:.::|..|:.|..|..:.||...|:|.|  .|
Yeast   332 --YLFCVLGTVFSELSINSALTYYGSYATSHGISANDAYTLIMIINVCGIPGRWVPGYLSD--KF 392

  Fly   721 DRKKT--YTLCILGAGCAVLTIPFAKTLVLVGLSAAVYGLCLGSWYVLMPVLLADVFGTDRISSS 783
            .|...  .||..|.....|..:||...|..:.:.:|:||.|.||.:.|:||....:..|:.....
Yeast   393 GRFNVAIATLLTLFIVMFVGWLPFGTNLTNMYVISALYGFCSGSVFSLLPVCCGQISKTEEFGKR 457

  Fly   784 YGLVRMFQSIGAISVPPLAGLMRDL--SGDYE--------------ICF-----YCMG 820
            |..:......|.:...|:.|.:..:  :.||:              :|:     ||:|
Yeast   458 YSTMYFVVGFGTLVGIPITGAIISIKTTADYQHYIIFCGLATFVSAVCYIISRAYCVG 515

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Sln	NP_610706.1	MFS	235..>411	CDD:119392	35/176 (20%)
		MFS	<656..827	CDD:119392	46/189 (24%)
		MFS_1	658..>847	CDD:284993	46/187 (25%)
MCH5	NP_014951.4	MFS_MCT_SLC16	106..510	CDD:340910	103/608 (17%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C157343233
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG2504
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	128	1.000	Inparanoid score	I1261
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		mtm13433
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11360
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	8	7.850