DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Sln and MCH4

DIOPT Version :9

Sequence 1:	NP_610706.1	Gene:	Sln / 36263	FlyBaseID:	FBgn0033657	Length:	855	Species:	Drosophila melanogaster
Sequence 2:	NP_014522.1	Gene:	MCH4 / 854030	SGDID:	S000005479	Length:	501	Species:	Saccharomyces cerevisiae

Alignment Length:	296	Identity:	77/296 - (26%)
Similarity:	130/296 - (43%)	Gaps:	44/296 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly   154 RPLIAKSHELRSSR--------KSGSGSG--SGLNTARSRCVRRAKERERDRVTVARRSKQVVKD 208
            |.|.:|.||.:|:|        :.|..||  ...|.|.:...:.:.:.:.|...:...:.:|:..
Yeast    12 RFLFSKDHEAQSTRDHDVELETREGPSSGYNPNFNAADAILKKNSDQVDLDVNKLTNVTSRVLNT 76

  Fly   209 RDSSTTTTESGGPNVEPPDGGY-GWFIVFGAFSVQFWVAGLVKSYGVL--YVEIMETFPSSTATV 270
            .::|....:    :.|.||||. .|.:|||||.....|.||:.|.|.:  |:...:....|::|:
Yeast    77 PEASLIYDD----DREFPDGGLKAWLVVFGAFMGLVPVFGLINSLGAIESYISKHQLANISSSTI 137

  Fly   271 ASWIPAILSALCLVLAPLSSALCQR-----FSCR-TVVFVGGIFCAMGMILSYFATSLLHLLLTF 329
             |||.::..|:..:...||.....|     ..|. ||::.||:|....      ..|:...:|.|
Yeast   138 -SWIFSLYLAISFLSCILSGGYFDRNGSIGLMCTGTVIYAGGLFALAN------CKSVWQFILAF 195

  Fly   330 GVLTGIGGGLSTTPGIVIVSQYFDKHRALANGICVSGTAAGSFILPVLIKHLAENCGFHGTILIL 394
            .|.:|:|.|:..||.|..|:.:|.|.|.:|..|...|.:.|..:.|::::.|.:..||...|.||
Yeast   196 SVCSGLGTGILMTPLIGTVATWFLKRRGIATSISTMGGSIGGIVFPIMLRKLYKEVGFQWAIRIL 260

  Fly   395 GGCMLHVCVSATLYRPISAYTDQDSGQGQEETAKPL 430
            .    .:|::..:...:.|          .|..||:
Yeast   261 S----FICLTCLICASVLA----------RERTKPV 282

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Sln	NP_610706.1	MFS	235..>411	CDD:119392	52/183 (28%)
		MFS	<656..827	CDD:119392
		MFS_1	658..>847	CDD:284993
MCH4	NP_014522.1	MFS_MCT_SLC16	96..490	CDD:340910	57/208 (27%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C157343234
Domainoid	1	1.000	72	1.000	Domainoid score	I2205
eggNOG	1	0.900	-	-		E1_KOG2504
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		mtm13433
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11360
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	8	7.800