Protein Alignment Sln and Slc16a3

DIOPT Version :10

• Sequence 1: NP_610706.1
• Gene: Sln / 36263
• FlyBaseID: FBgn0033657
• Length: 855
• Species: Drosophila melanogaster
• Sequence 2: NP_110461.1
• Gene: Slc16a3 / 80878
• RGDID: 620603
• Length: 471
• Species: Rattus norvegicus
• Alignment Length: 656
• Identity: 133/656 - (20%)
• Similarity: 232/656 - (35%)
• Gaps: 249/656 - (37%)

  Fly   217 ESGGPNVEPPDGGYGWFIVFGAFSVQFWVAGLVKSYGVLYVEIMETFP---SSTATVASWIPAIL 278
            :.|...::.||||:||.::||.|.:..:.....|:..|.:.|:|..|.   |.||    ||.:||
  Rat     7 DEGPTGIKAPDGGWGWAVLFGCFIITGFSYAFPKAVSVFFKELMHEFGIGYSDTA----WISSIL 67

  Fly   279 SALCLVLAPLSSALCQRFSCRTVVFVGGIFCAMGMILSYFATSLLHLLLTFGVLTGIGGGLSTTP 343
            .|:.....||.|....||.||.|:.|||:|.::||:.:.|..|::.:.||.||:||:|..|:..|
  Rat    68 LAMLYGTGPLCSMCVNRFGCRPVMLVGGLFASLGMVAASFCRSIIQIYLTTGVITGLGLALNFQP 132

  Fly   344 GIVIVSQYFDKHRALANGICVSGTAAGSFILPVLIKHLAENCGFHGTILILGGCMLHVCVSATLY 408
            .::::::||:|.|.:|||:..:|:......|..|.:.|.::.|:.|..|||||.:|:.||.|.|.
  Rat   133 SLIMLNRYFNKRRPMANGLAAAGSPVFLCALSPLGQLLQDHYGWRGGFLILGGLLLNCCVCAALM 197

  Fly   409 RPISAYTDQDSGQGQEETAKPLNEDINPSTTGILTTSTYLDTCDVGAGHELSDKFIEHLFLEESK 473
            ||:.|                      |..:|             ||
  Rat   198 RPLVA----------------------PQASG-------------GA------------------ 209

  Fly   474 NHLNYYASKQPAQDKSAQESDDEVKDIIGETTFIKPMKKVRSSGLLHSVEDLSTDSTWVYRKHSG 538
                                                                             
  Rat   210 ----------------------------------------------------------------- 209

  Fly   539 TDSNRGSRRRRNVFANDEVISKIQAHLEKPLSPPSVVSRGLSKSMEIPTPVSNLSDLKQQPVEQA 603
                                                                             
  Rat   210 ----------------------------------------------------------------- 209

  Fly   604 ELGILDSQLVESIIDGDGHLAADEDDDDDEERGPRTCCERIEMYLDISLLQDPSFILMCLSVTLM 668
                                         |..||:....|:   ||:|:.:|..|::..::.::|
  Rat   210 -----------------------------EPHGPQRPSPRL---LDLSVFRDRGFLIYAVAASIM 242

  Fly   669 SVGCPYMLYYLPAHVIS----IGYNKSEAGYLVAISAVLDLIGRLGLGWLCDLQLFDRKKTYTLC 729
            .:|    |:..|..|:|    :|...::|.:|:.|...:|:..|...|::..|:   :.:.|::.
  Rat   243 VLG----LFVPPVFVVSYAKDMGVPDTKAAFLLTILGFIDIFARPTAGFITGLK---KVRPYSVY 300

  Fly   730 ILGAGCAVLTIPFAKTLVLVGLSAAVYG----LCL--GSWYVLMPVL----LADVFGTDRISSSY 784
            :..     ..:.|.....|.|.:|:.||    .|:  |..|.::..|    |..:.||.:.||:.
  Rat   301 LFS-----FAMFFNGFTDLTGSTASDYGGLVVFCIFFGISYGMVGALQFEVLMAIVGTQKFSSAI 360

  Fly   785 GLVRMFQSIGAISVPPLAGLMRDLSGDYEICFYCMGSCMVLGTTPLIVWSIL-EARNHRLFVQRE 848
            |||.:.:::..:..||..|.:.|.:..|:..|...|:.::..:..|::.:.. ..:..|..|.:.
  Rat   361 GLVLLLEAVAVLIGPPSGGKLLDATKVYKYVFILAGAEVLTSSLVLLLGNFFCIGKRKRPEVTKP 425

  Fly   849 EEECEE 854
            ||...|
  Rat   426 EEVASE 431

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Sln	NP_610706.1	MFS_MCT_SLC16	231..>409	CDD:340910	66/180 (37%)
		MFS	<652..834	CDD:475125	43/195 (22%)
Slc16a3	NP_110461.1	MFS_MCT3_4	21..410	CDD:340988	123/619 (20%)
		Basolateral sorting signal. /evidence=ECO:0000250|UniProtKB:O15427	429..447		1/3 (33%)
		Basolateral sorting signal. /evidence=ECO:0000250|UniProtKB:O15427	447..471