Protein Alignment Sln and SLC16A2

DIOPT Version :10

• Sequence 1: NP_610706.1
• Gene: Sln / 36263
• FlyBaseID: FBgn0033657
• Length: 855
• Species: Drosophila melanogaster
• Sequence 2: NP_006508.2
• Gene: SLC16A2 / 6567
• HGNCID: 10923
• Length: 539
• Species: Homo sapiens
• Alignment Length: 661
• Identity: 122/661 - (18%)
• Similarity: 216/661 - (32%)
• Gaps: 224/661 - (33%)

  Fly   202 SKQVVKDRDSSTTTTESGGPNVEPPDGGYGWFIVFGAFSVQFWVAGLVKSYGVLYVEIMETFPSS 266
            |::|.:...:.|..|.......:||:||:||.:||.|......:.|:..|.|:||..::|.....
Human    71 SERVHEPEPTPTVETRGTARGFQPPEGGFGWVVVFAATWCNGSIFGIHNSVGILYSMLLEEEKEK 135

  Fly   267 TATV---ASWIPAILSALCLVLAPLSSALCQRFSCRTVVFVGGIFCAMGMILSYFATSLLHLLLT 328
            ...|   |:|:.|:...:....:|:.|....|..||.....|.....:|:..|.|.:||.....|
Human   136 NRQVEFQAAWVGALAMGMIFFCSPIVSIFTDRLGCRITATAGAAVAFIGLHTSSFTSSLSLRYFT 200

  Fly   329 FGVLTGIGGGLSTTPGIVIVSQYFDKHRALANGICVSGTAAGSFILPVLIKHLAENCGFHGTILI 393
            :|:|.|.|...:..|.:||:..||.:...||||:..:|::..|...|.||:.|.:......|..:
Human   201 YGILFGCGCSFAFQPSLVILGHYFQRRLGLANGVVSAGSSIFSMSFPFLIRMLGDKIKLAQTFQV 265

  Fly   394 LGGCMLHVCVSATLYRPISAYTDQDSGQGQEETAKPLNEDINPSTTGILTTSTYLDTCDVGAGHE 458
            |...|..:.:.:..|||:                .|.::| .||..|:.|
Human   266 LSTFMFVLMLLSLTYRPL----------------LPSSQD-TPSKRGVRT--------------- 298

  Fly   459 LSDKFIEHLFLEESKNHLNYYASKQPAQDKSAQESDDEVKDIIGETTFIKPMKKVRSSGLLHSVE 523
                 :...||.:.:.:.|....:|
Human   299 -----LHQRFLAQLRKYFNMRVFRQ---------------------------------------- 318

  Fly   524 DLSTDSTWVYRKHSGTDSNRGSRRRRNVFANDEVISKIQAHLEKPLSPPSVVSRGLSKSMEIPTP 588
              .|...|.:
Human   319 --RTYRIWAF------------------------------------------------------- 326

  Fly   589 VSNLSDLKQQPVEQAELGILDSQLVESIIDGDGHLAADEDDDDDEERGPRTCCERIEMYLDISLL 653
                      .:..|.||.....:         ||....:::..|                   :
Human   327 ----------GIAAAALGYFVPYV---------HLMKYVEEEFSE-------------------I 353

  Fly   654 QDPSFILMCLSVTLMSVGCPYMLYYLPAHVISIGYNKSEAGYLVAISAVLDLIGRLGLGWLCDLQ 718
            ::...:|:|:..|                          :|           :|||..|.:.| .
Human   354 KETWVLLVCIGAT--------------------------SG-----------LGRLVSGHISD-S 380

  Fly   719 LFDRKKTY--TLCILGAGCAVLTIPFAKT---LVLVGLSAAVYGLCLGSWYVLMPVLLADVFGTD 778
            :...||.|  .|..|..|...:.||..:.   |::|.|   ..|||.|.:..:|..:..::.|..
Human   381 IPGLKKIYLQVLSFLLLGLMSMMIPLCRDFGGLIVVCL---FLGLCDGFFITIMAPIAFELVGPM 442

  Fly   779 RISSSYGLVRMFQSIGAISVPPLAGLMRDLSGDYEICFYCMGSCMVLGTTPLIVWSILEARNHRL 843
            :.|.:.|.:....::..|:.||:|||:|:..|||.:.||..|...::|.   ::...:...:.|:
Human   443 QASQAIGYLLGMMALPMIAGPPIAGLLRNCFGDYHVAFYFAGVPPIIGA---VILFFVPLMHQRM 504

  Fly   844 FVQREEEECEE 854
            |.:.:.:..::
Human   505 FKKEQRDSSKD 515

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Sln	NP_610706.1	MFS_MCT_SLC16	231..>409	CDD:340910	49/180 (27%)
		MFS	<652..834	CDD:475125	42/186 (23%)
SLC16A2	NP_006508.2	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..92		4/20 (20%)
		MFS_MCT8_10	100..498	CDD:340978	112/613 (18%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	508..539		0/8 (0%)