DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Sln and SLC16A2

DIOPT Version :9

Sequence 1:	NP_610706.1	Gene:	Sln / 36263	FlyBaseID:	FBgn0033657	Length:	855	Species:	Drosophila melanogaster
Sequence 2:	NP_006508.2	Gene:	SLC16A2 / 6567	HGNCID:	10923	Length:	539	Species:	Homo sapiens

Alignment Length:	661	Identity:	122/661 - (18%)
Similarity:	216/661 - (32%)	Gaps:	224/661 - (33%)

- Green bases have known domain annotations that are detailed below.

  Fly   202 SKQVVKDRDSSTTTTESGGPNVEPPDGGYGWFIVFGAFSVQFWVAGLVKSYGVLYVEIMETFPSS 266
            |::|.:...:.|..|.......:||:||:||.:||.|......:.|:..|.|:||..::|.....
Human    71 SERVHEPEPTPTVETRGTARGFQPPEGGFGWVVVFAATWCNGSIFGIHNSVGILYSMLLEEEKEK 135

  Fly   267 TATV---ASWIPAILSALCLVLAPLSSALCQRFSCRTVVFVGGIFCAMGMILSYFATSLLHLLLT 328
            ...|   |:|:.|:...:....:|:.|....|..||.....|.....:|:..|.|.:||.....|
Human   136 NRQVEFQAAWVGALAMGMIFFCSPIVSIFTDRLGCRITATAGAAVAFIGLHTSSFTSSLSLRYFT 200

  Fly   329 FGVLTGIGGGLSTTPGIVIVSQYFDKHRALANGICVSGTAAGSFILPVLIKHLAENCGFHGTILI 393
            :|:|.|.|...:..|.:||:..||.:...||||:..:|::..|...|.||:.|.:......|..:
Human   201 YGILFGCGCSFAFQPSLVILGHYFQRRLGLANGVVSAGSSIFSMSFPFLIRMLGDKIKLAQTFQV 265

  Fly   394 LGGCMLHVCVSATLYRPISAYTDQDSGQGQEETAKPLNEDINPSTTGILTTSTYLDTCDVGAGHE 458
            |...|..:.:.:..|||:                .|.::| .||..|:.|
Human   266 LSTFMFVLMLLSLTYRPL----------------LPSSQD-TPSKRGVRT--------------- 298

  Fly   459 LSDKFIEHLFLEESKNHLNYYASKQPAQDKSAQESDDEVKDIIGETTFIKPMKKVRSSGLLHSVE 523
                 :...||.:.:.:.|....:|
Human   299 -----LHQRFLAQLRKYFNMRVFRQ---------------------------------------- 318

  Fly   524 DLSTDSTWVYRKHSGTDSNRGSRRRRNVFANDEVISKIQAHLEKPLSPPSVVSRGLSKSMEIPTP 588
              .|...|.:
Human   319 --RTYRIWAF------------------------------------------------------- 326

  Fly   589 VSNLSDLKQQPVEQAELGILDSQLVESIIDGDGHLAADEDDDDDEERGPRTCCERIEMYLDISLL 653
                      .:..|.||.....:         ||....:::..|                   :
Human   327 ----------GIAAAALGYFVPYV---------HLMKYVEEEFSE-------------------I 353

  Fly   654 QDPSFILMCLSVTLMSVGCPYMLYYLPAHVISIGYNKSEAGYLVAISAVLDLIGRLGLGWLCDLQ 718
            ::...:|:|:..|                          :|           :|||..|.:.| .
Human   354 KETWVLLVCIGAT--------------------------SG-----------LGRLVSGHISD-S 380

  Fly   719 LFDRKKTY--TLCILGAGCAVLTIPFAKT---LVLVGLSAAVYGLCLGSWYVLMPVLLADVFGTD 778
            :...||.|  .|..|..|...:.||..:.   |::|.|   ..|||.|.:..:|..:..::.|..
Human   381 IPGLKKIYLQVLSFLLLGLMSMMIPLCRDFGGLIVVCL---FLGLCDGFFITIMAPIAFELVGPM 442

  Fly   779 RISSSYGLVRMFQSIGAISVPPLAGLMRDLSGDYEICFYCMGSCMVLGTTPLIVWSILEARNHRL 843
            :.|.:.|.:....::..|:.||:|||:|:..|||.:.||..|...::|.   ::...:...:.|:
Human   443 QASQAIGYLLGMMALPMIAGPPIAGLLRNCFGDYHVAFYFAGVPPIIGA---VILFFVPLMHQRM 504

  Fly   844 FVQREEEECEE 854
            |.:.:.:..::
Human   505 FKKEQRDSSKD 515

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Sln	NP_610706.1	MFS	235..>411	CDD:119392	49/178 (28%)
		MFS	<656..827	CDD:119392	41/175 (23%)
		MFS_1	658..>847	CDD:284993	44/193 (23%)
SLC16A2	NP_006508.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..92		4/20 (20%)
		2A0113	86..513	CDD:273325	118/642 (18%)
		MFS	101..498	CDD:119392	111/612 (18%)
		DUF1564	<286..>334	CDD:284922	12/175 (7%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	508..539		0/8 (0%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165145581
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG2504
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D916876at2759
OrthoFinder	1	1.000	-	-		FOG0000033
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	5	4.750