DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Sln and slc16a10

DIOPT Version :9

Sequence 1:	NP_610706.1	Gene:	Sln / 36263	FlyBaseID:	FBgn0033657	Length:	855	Species:	Drosophila melanogaster
Sequence 2:	NP_001073497.1	Gene:	slc16a10 / 566499	ZFINID:	ZDB-GENE-040724-214	Length:	505	Species:	Danio rerio

Alignment Length:	672	Identity:	110/672 - (16%)
Similarity:	202/672 - (30%)	Gaps:	256/672 - (38%)

- Green bases have known domain annotations that are detailed below.

  Fly   206 VKDRDSSTTTTESGGP-NVEPPDGGYGWFIVFGAFSVQFWVAGLVKSYGVLYVEIMETFPS---- 265
            :|..:..|..:|...| ..|||:||:||.::..:......|.|:..::|:::|.::..|.|
Zfish    44 LKQENGCTKASEQKSPEEFEPPEGGWGWVVMLASMWCNGSVFGIQNAFGIMFVYLLNEFGSEHDA 108

  Fly   266 ----STATVASWIPAILSALCLVLAPLSSALCQRFSCRTVVFVGGIFCAMGMILSYFATSLLHLL 326
                .||    |:.::...:....:|:.|.......||.....|.....:|::.|.|.|||..:.
Zfish   109 DLRFKTA----WVGSLSMGMIFFCSPIVSVFTDLLGCRITAVGGAAVGCVGLLASSFVTSLGPMY 169

  Fly   327 LTFGVLTGIGGGLSTTPGIVIVSQYFDKHRALANGICVSGTAAGSFILPVLIKHLAENCGFHGTI 391
            .|:|::...|...:..|.:||:..||.:...|.|||..:|::..:..||.::..|.::.|.:.|:
Zfish   170 FTYGIVFACGCSFAYQPSLVILGHYFKRRLGLVNGIVTAGSSVFTITLPYMLSGLLKSVGLYHTL 234

  Fly   392 LILGGCMLHVCVSATLYRPISAYTDQDSGQGQEETAKPLNEDINPSTTGILTTSTYLDTCDVGAG 456
            .:|...|..:.::...|:|:
Zfish   235 RVLAIFMFILMLAGLTYKPL--------------------------------------------- 254

  Fly   457 HELSDKFIEHLFLEESKNHLNYYASKQPAQDKSAQESDDEVKDIIGETTFIKPMKKVRSSGLLHS 521

Zfish   255 ----------------------------------------------------------------- 254

  Fly   522 VEDLSTDSTWVYRKHSGTDSNRGSRRRRNVFANDEVISKIQAHLEKPLSPPSVVSRGLSKSMEIP 586
                                                                           :|
Zfish   255 ---------------------------------------------------------------LP 256

  Fly   587 TPVSNLSDLKQQPVEQAELGILDSQLVESIIDGDGHLAADEDDDDDEERGPRTCCERIEMYLDIS 651
            .|||:..                                           |.:.|..:....:::
Zfish   257 KPVSSSK-------------------------------------------PGSRCPPLSRIFNVN 278

  Fly   652 LLQDPSFILMCLSVTLMSVGCPYMLY-------YLPAHVISIGYNKSEAGYLVAISAVLDLIGRL 709
            :.:.       |...:.:.|.|..||       :|..||......::....|:|...:...:|||
Zfish   279 IWKS-------LGYRIWAFGIPAALYGYFVPYVHLMTHVEERFGPEANKEVLLACIGITSGVGRL 336

  Fly   710 GLGWLCDL-----QLFDRKKTYTLCILGAGCAVLTIPFAKTLVLVGLSAA--VYGLCLGSWYVLM 767
            ..|.:.|.     ::|.:..::.:    .|...:.||...  |..||.|.  :.||..|.:..:|
Zfish   337 IFGRVADYVPGVNKVFLQVSSFMV----IGVMSMMIPLCH--VFGGLIAVCLLMGLFDGCFICIM 395

  Fly   768 PVLLADVFGTDRISSSYGLVRMFQSIGAISVPPLAGLMRDLSGDYEICFYCMGSCMVLGTTPLIV 832
            ..:..::.|:..:|.:.|.:....||.....||:||.:||..|.|::.||..|...::|...|..
Zfish   396 APIAFELVGSQNVSQAIGFLLGMMSIPMTVGPPIAGFLRDRLGSYDVAFYLAGIPPLIGGAVLCA 460

  Fly   833 WSILEARNHRLFVQREEEECEE 854
            ...:|||..|.......|..|:
Zfish   461 IPWVEARRKRREAANTAENTEK 482

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Sln	NP_610706.1	MFS	235..>411	CDD:119392	41/183 (22%)
		MFS	<656..827	CDD:119392	43/184 (23%)
		MFS_1	658..>847	CDD:284993	49/202 (24%)
slc16a10	NP_001073497.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..64		4/19 (21%)
		2A0113	56..458	CDD:273325	100/634 (16%)
		MFS	71..462	CDD:119392	94/623 (15%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	474..505		2/9 (22%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170578884
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG2504
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D916876at2759
OrthoFinder	1	1.000	-	-		FOG0000033
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	6	5.750