Protein Alignment Sln and mct-4

DIOPT Version :10

• Sequence 1: NP_610706.1
• Gene: Sln / 36263
• FlyBaseID: FBgn0033657
• Length: 855
• Species: Drosophila melanogaster
• Sequence 2: NP_001041267.1
• Gene: mct-4 / 180766
• WormBaseID: WBGene00003986
• Length: 777
• Species: Caenorhabditis elegans
• Alignment Length: 701
• Identity: 168/701 - (23%)
• Similarity: 314/701 - (44%)
• Gaps: 138/701 - (19%)

  Fly   211 SSTTTTESGGPNVEP------PDGGYGWFIVFGAFSVQFWVAGLVKSYGVLYVEIMETFPSSTAT 269
            ||..:...|...|||      |||||||.|||.||.....|.|:..::........|.:..|..
 Worm    49 SSQYSINMGVQQVEPLLVPQAPDGGYGWVIVFAAFMSNLVVDGISTAFSEFKQSYKERYQESDG- 112

  Fly   270 VASWIPAILSALCLVLAPLSSALCQRFSCRTVVFVGGIFCAMGMILSYFATSLLHLLLTFGVLTG 334
            :..:|.:::....|::.||.||||.::..|.||..||:...:..:::..:.::...:|.:||:.|
 Worm   113 LTVFIGSLIIGTYLLVGPLVSALCNKYEQRYVVMAGGLISGIAFMIAPASPNIYVFMLIYGVMGG 177

  Fly   335 IGGGLSTTPGIVIVSQYFDKHRALANGICVSGTAAGSFILPVLIKHLAENCGFHGTILILGGCML 399
            :|.|:...|.||:|..|||..||:|.||.|:|:..|:|::|::.:....|.|:..||.:| ..|:
 Worm   178 LGFGMIYLPAIVVVGFYFDSKRAMATGISVAGSGVGTFLVPLICQVCIANLGWQKTIWVL-AVMI 241

  Fly   400 HVCV-SATLYRPISAYTDQDSGQGQEETAKPLNEDINPSTTGILTTSTYLDTCDVGAGHELSDKF 463
            ..|| ...||||:...   |..:.:::..:||.:.::.
 Worm   242 FSCVFYGYLYRPLPMV---DLNEIRDQEMEPLRQALSK--------------------------- 276

  Fly   464 IEHLFLEESKNHLNYYASKQPAQDKSAQESDDEVKD-IIGETTFIKPMKKVRSSG---------L 518
                 :|:.::.    |.:.|..::|...:...::| .:.:...::.::.:.:.|         .
 Worm   277 -----VEDDEDE----AVESPHPNRSTSAASGAIEDEAVSQNPEVQRLRSILTEGDEGSETPKSD 332

  Fly   519 LHSVEDLSTDSTWVYRKHSGTDSNRGSRR----RRNVFANDEVISKIQAH--------LEKP--L 569
            .|.|...:...:   |||:.| ||.||:.    .|...::|..:|::.|.        |.|.  .
 Worm   333 AHKVRSHTATRS---RKHTMT-SNSGSQHDLKLSRGNLSSDNRLSRVSARDFNQSLSKLSKSGGA 393

  Fly   570 SPPSVVSRGLS-KSMEIPT---------PVSNLSDLKQQ-----------PVEQAELGILDSQL- 612
            |..|:...|:. |..:.|.         .:.||.:.|::           .:.::.:|...|||
 Worm   394 SNLSIAMSGVDPKEFQRPMNRQDIFYGGSIQNLKEFKEEGTMAGYRASTLSIPRSVVGQAVSQLN 458

  Fly   613 ---VESIIDGDGHLAADEDD------DDDEERGPRTCCERIEM--------YLDISLLQDPSFIL 660
               ..|.:.|.| :|.||::      ||.       ||:.:.:        .:|::||::.:.::
 Worm   459 LSRTGSRLGGPG-IAEDEEEMIEPFVDDG-------CCKVLPLPMRNALSEMIDLNLLKNKTMMI 515

  Fly   661 MCLSVTLMSVGCPYMLYYLPAHVI-----SIGYNKSEAGYLVAISAVLDLIGRLGLGWLCDLQLF 720
            :|:|..|..:|     :|:|...:     |:..:.|.|.:||.|..|.:.|||:..|||.|.::.
 Worm   516 LCISNLLGMMG-----FYIPIMFLKDLSESMKLDMSLAMFLVPIFGVFNTIGRVFFGWLTDQKIL 575

  Fly   721 DRKKTYTLCILGAGCAVLTIPFAKTLVLVGLSAAVYGLCLGSWYVLMPVLLADVFGTDRISSSYG 785
            .......|.::.:|...|..|...::......|.|:|..:.::..|..::|||:.|.:.:::|:|
 Worm   576 SALTINNLSLIVSGLLTLACPLLTSIAGQYFYAIVFGFIISAYICLTSIVLADLMGLENLTNSFG 640

  Fly   786 LVRMFQSIGAISVPPLAGLMRDLSGDYEICFYCMG-----SCMVLGTTPLI 831
            |:.:.:.|.::..||.||::.|::|.|:..||..|     :.::..|.|.:
 Worm   641 LLVVARGIASLVGPPFAGIVYDITGSYDTAFYFGGLVLLVAGLISATIPFV 691

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Sln	NP_610706.1	MFS_MCT_SLC16	231..>409	CDD:340910	56/178 (31%)
		MFS	<652..834	CDD:475125	50/190 (26%)
mct-4	NP_001041267.1	MFS_MCT_SLC16	75..>252	CDD:340910	56/178 (31%)
		MFS	<507..689	CDD:475125	49/186 (26%)