DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment S2P and mbtps2

DIOPT Version :9

Sequence 1:	NP_610705.1	Gene:	S2P / 36262	FlyBaseID:	FBgn0033656	Length:	508	Species:	Drosophila melanogaster
Sequence 2:	NP_001017061.1	Gene:	mbtps2 / 549815	XenbaseID:	XB-GENE-953524	Length:	494	Species:	Xenopus tropicalis

Alignment Length:	522	Identity:	151/522 - (28%)
Similarity:	254/522 - (48%)	Gaps:	53/522 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MDPFVFFIVLASLYGVLYFFDRFFKS--CMHYPYDAFLKNTGLSINFMSLHWHTSAFNRTLLRWG 63
            |.|....:|:...:..:|..|.|..|  .:...|:.:|...||||:...:.|.|:.|||...:||
Frog     1 MIPISLVVVVLGGWCAIYLADTFLTSSQSLKNSYEEWLTARGLSISPFHIRWQTTLFNRLFYKWG 65

  Fly    64 SAGNSCTRRVMITSFNVGVLVTFSLLPIGLILLIATIFSSGE----------QDSSSSVSSPVGV 118
                ......:...|.:||       ..|:|.:..:||..|:          .:|.:|.:..:
Frog    66 ----RWKPNFLYIWFTLGV-------AFGIIAMFGSIFLLGKTLVQTLNQMMAESPASQNDRM-- 117

  Fly   119 PVQLEILLPGVNLPLEEIGYYITTLVLCLVVHEMGHALAAVMEDVPVTGFGIKFIFCL-PLAYTE 182
               |::::||||||:.::.|:.:.:::..|:||:||.:|||.|.|...|||: |||.: |.|:.:
Frog   118 ---LQVVVPGVNLPISQLSYFFSAILISGVLHEVGHGVAAVRESVRFNGFGM-FIFIVYPGAFVD 178

  Fly   183 LSHDHLNSLRWFRKLRVLCAGIWHNFVFAGVCYLLISTVGITMSPLYAYNQHVVVTELTRKSPLR 247
            |...||..:...::||:.|||:|||||...:..|::..:...:.|.|......:|||:...||..
Frog   179 LFTTHLQLVSPVQQLRIFCAGVWHNFVLGILGILILVPLPALLFPFYYTGVGALVTEVVEDSPAS 243

  Fly   248 GERGLQVDNQITQVNGCPVNSEESWVTCLQNSLKL-KPGYCVSADFVQLNDESSAISHHSIDGQL 311
            |.|||.|.:.||.|..|.|...:.|.|||....:: :.|||::...:|.....|.: :..:||.:
Frog   244 GPRGLFVQDLITHVQDCQVTGVDDWHTCLTEISQMPQIGYCINTATLQQLQFPSRV-YRRLDGSI 307

  Fly   312 QCCDELNPNVSCFEVVEDANGDVPVELPQHVCLNVRRTLEEVSEHCSSGV-CNE----GFCLRPL 371
            :||:..:.:..||....::|..      |..||..|:::.. |:.|.|.: |.:    ..|..|.
Frog   308 ECCNNNSLSDICFSYNSNSNQQ------QFACLPARKSIHN-SQECRSNIDCQKTDAASVCAVPS 365

  Fly   372 IRNITAIMTFKRQNFRGEKLP--PVIYVGHPWDVTRTVEVSAFVPRYSLLKAAWPDAWLLLLKYN 434
            |.|.|.::..|..       |  .::::|:|..:...|.:|:|||||:.|..:.|.......||.
Frog   366 IENQTRLIRVKHS-------PQLDMLFIGYPVHLQYAVSLSSFVPRYNFLSISLPVVIETFCKYL 423

  Fly   435 VVFSIGLALINAIPCFGFDGAHITSTVIHSFLVGRVDQHAKRDIISLIITSVGSLLFALALLKVA 499
            :..|..||:|||:|||..||..|.::.|.:.|...:.:...|::::..|...||.|....::...
Frog   424 ISLSGALAVINAVPCFALDGQWILNSFIEATLSSVIAEKQNRELLAFFILLAGSALLTANVVLGL 488

  Fly   500 WL 501
            |:
Frog   489 WM 490

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
S2P	NP_610705.1	S2P-M50	6..>218	CDD:299148	68/224 (30%)
		RseP	136..508	CDD:223821	114/375 (30%)
		S2P-M50	<427..494	CDD:299148	21/66 (32%)
mbtps2	NP_001017061.1	S2P-M50_PDZ_SREBP	6..>217	CDD:100083	68/227 (30%)
mbtps2	NP_001017061.1	Peptidase_M50	134..480	CDD:308008	112/361 (31%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	172	1.000	Domainoid score	I3687
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	1	1.000	-	-		H9287
Inparanoid	1	1.050	228	1.000	Inparanoid score	I3385
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1012405at2759
OrthoFinder	1	1.000	-	-		FOG0006242
OrthoInspector	1	1.000	-	-		oto102888
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R9506
SonicParanoid	1	1.000	-	-		X4524
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	8	8.090