DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment S2P and MBTPS2

DIOPT Version :9

Sequence 1:	NP_610705.1	Gene:	S2P / 36262	FlyBaseID:	FBgn0033656	Length:	508	Species:	Drosophila melanogaster
Sequence 2:	NP_056968.1	Gene:	MBTPS2 / 51360	HGNCID:	15455	Length:	519	Species:	Homo sapiens

Alignment Length:	537	Identity:	160/537 - (29%)
Similarity:	265/537 - (49%)	Gaps:	58/537 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MDPFVFFIVLASLYGVLYFFDRFFKSCMHY--PYDAFLKNTGLSINFMSLHWHTSAFNRTLLRWG 63
            |.|....:|:...:.|:|..|...||.:::  .|:.:|:|.||||:...:.|.|:.|||....||
Human     1 MIPVSLVVVVVGGWTVVYLTDLVLKSSVYFKHSYEDWLENNGLSISPFHIRWQTAVFNRAFYSWG 65

  Fly    64 SAGNSCTRRVMITSFNVGVLV-------TFSLLPIGLILLIATIF----------------SSGE 105
            ..    ..|::...||.|::.       :|.||...|:..:|.:.                ||..
Human    66 RR----KARMLYQWFNFGMVFGVIAMFSSFFLLGKTLMQTLAQMMADSPSSYSSSSSSSSSSSSS 126

  Fly   106 QDSSSSVSSPVGVPVQLEILLPGVNLPLEEIGYYITTLVLCLVVHEMGHALAAVMEDVPVTGFGI 170
            ..||||.||.:.....|::::||:|||:.::.|:.|.:::..||||:||.:||:.|.|...||||
Human   127 SSSSSSSSSSLHNEQVLQVVVPGINLPVNQLTYFFTAVLISGVVHEIGHGIAAIREQVRFNGFGI 191

  Fly   171 KFIFCLPLAYTELSHDHLNSLRWFRKLRVLCAGIWHNFVFAGVCYLLISTVGITMSPLYAYNQHV 235
            ......|.|:.:|...||..:...::||:.|||||||||.|.:..|.:..:.:.:.|.|.....|
Human   192 FLFIIYPGAFVDLFTTHLQLISPVQQLRIFCAGIWHNFVLALLGILALVLLPVILLPFYYTGVGV 256

  Fly   236 VVTELTRKSPLRGERGLQVDNQITQVNGCPVNSEESWVTCLQNSLKLKP--GYCVSADFVQLNDE 298
            ::||:...||..|.|||.|.:.:|.:..|||.:.:.|..|| :::..:|  |||:||..:|  ..
Human   257 LITEVAEDSPAIGPRGLFVGDLVTHLQDCPVTNVQDWNECL-DTIAYEPQIGYCISASTLQ--QL 318

  Fly   299 SSAI-SHHSIDGQLQCCDELNPNVSCFEVVEDANGDVPVELPQHVCLNVRRTLE-----EVSEHC 357
            |..: ::..:||..:||:..:....||....:.|..:      |.||..|:.:|     ..::.|
Human   319 SFPVRAYKRLDGSTECCNNHSLTDVCFSYRNNFNKRL------HTCLPARKAVEATQVCRTNKDC 377

  Fly   358 SSGVCNEGFCLRPLIRNITAIMTFKRQNFRGEKLPP---VIYVGHPWDVTRTVEVSAFVPRYSLL 419
            ... .:..||:.|.:...|.::..|.        ||   ::|||||..:..||.:::|:||::.|
Human   378 KKS-SSSSFCIIPSLETHTRLIKVKH--------PPQIDMLYVGHPLHLHYTVSITSFIPRFNFL 433

  Fly   420 KAAWPDAWLLLLKYNVVFSIGLALINAIPCFGFDGAHITSTVIHSFLVGRVDQHAKRDIISLIIT 484
            ....|......:||.:..|..||::||:|||..||..|.::.:.:.|...:..:..:|:|...|.
Human   434 SIDLPVVVETFVKYLISLSGALAIVNAVPCFALDGQWILNSFLDATLTSVIGDNDVKDLIGFFIL 498

  Fly   485 SVGSLLFALALLKVAWL 501
            ..||:|.|..:....|:
Human   499 LGGSVLLAANVTLGLWM 515

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
S2P	NP_610705.1	S2P-M50	6..>218	CDD:299148	77/236 (33%)
		RseP	136..508	CDD:223821	115/377 (31%)
		S2P-M50	<427..494	CDD:299148	21/66 (32%)
MBTPS2	NP_056968.1	S2P-M50_PDZ_SREBP	18..>229	CDD:100083	70/214 (33%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	115..135		6/19 (32%)
		PDZ	<255..>299	CDD:294084	17/44 (39%)
		S2P-M50	<419..508	CDD:100078	28/88 (32%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165140749
Domainoid	1	1.000	182	1.000	Domainoid score	I3472
eggNOG	1	0.900	-	-		E1_COG0750
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H9287
Inparanoid	1	1.050	248	1.000	Inparanoid score	I3258
Isobase	1	0.950	-	0	Normalized mean entropy	S7377
OMA	1	1.010	-	-		QHG55798
OrthoDB	1	1.010	-	-		D1012405at2759
OrthoFinder	1	1.000	-	-		FOG0006242
OrthoInspector	1	1.000	-	-		oto89025
orthoMCL	1	0.900	-	-		OOG6_103384
Panther	1	1.100	-	-	LDO	PTHR13325
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R9506
SonicParanoid	1	1.000	-	-		X4524
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	17	16.750