DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment S2P and Mbtps2

DIOPT Version :9

Sequence 1:	NP_610705.1	Gene:	S2P / 36262	FlyBaseID:	FBgn0033656	Length:	508	Species:	Drosophila melanogaster
Sequence 2:	NP_758511.1	Gene:	Mbtps2 / 270669	MGIID:	2444506	Length:	515	Species:	Mus musculus

Alignment Length:	533	Identity:	161/533 - (30%)
Similarity:	265/533 - (49%)	Gaps:	54/533 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MDPFVFFIVLASLYGVLYFFDRFFKSCMHY--PYDAFLKNTGLSINFMSLHWHTSAFNRTLLRWG 63
            |.|....:|:...:..:|..|...||.:::  .|:.:|:|.||||:...:.|.||.|||....||
Mouse     1 MIPVSLLVVVVGGWTAVYLADLVLKSSVYFKHSYEDWLENNGLSISPFHIRWQTSIFNRAFYSWG 65

  Fly    64 SAGNSCTRRVMITSFNVGVLV-------TFSLLPIGLILLIATIF------------SSGEQDSS 109
            ..    ..|::...||.|::.       :|.||...|:..:|.:.            ||....||
Mouse    66 RR----KARMLYQWFNFGMVFGVIAMFSSFFLLGKTLMQTLAQMMADSPSPYSSSSSSSSSSSSS 126

  Fly   110 SSVSSPVGVPVQLEILLPGVNLPLEEIGYYITTLVLCLVVHEMGHALAAVMEDVPVTGFGIKFIF 174
            ||.||.:.....|::::||:|||:.::.|:...:::..||||:||.:||:.|.|...||||....
Mouse   127 SSSSSSLHNEQVLQVVVPGINLPVNQLTYFFAAVLISGVVHEIGHGIAAIREQVRFNGFGIFLFI 191

  Fly   175 CLPLAYTELSHDHLNSLRWFRKLRVLCAGIWHNFVFAGVCYLLISTVGITMSPLYAYNQHVVVTE 239
            ..|.|:.:|...||..:...::||:.|||||||||.|.:..|.:..:.:.:.|.|.....|::||
Mouse   192 IYPGAFVDLFTTHLQLISPVQQLRIFCAGIWHNFVLALLGILALVLLPVILLPFYYTGVGVLITE 256

  Fly   240 LTRKSPLRGERGLQVDNQITQVNGCPVNSEESWVTCLQNSLKLKP--GYCVSADFVQLNDESSAI 302
            :...||..|.|||.|.:.:|.:..|||.:.:.|..|| :::..:|  |||:||..:|  ..|..:
Mouse   257 VAEDSPAIGPRGLFVGDLVTHLQDCPVTNVQDWNECL-DTIAYEPQIGYCISASTLQ--QLSFPV 318

  Fly   303 -SHHSIDGQLQCCDELNPNVSCFEVVEDANGDVPVELPQHVCLNVRRTLEEV-----SEHCSSGV 361
             ::..:||..:||:..:....||....:.|..:      |.||..|:.:|..     ::.|.||
Mouse   319 RAYKRLDGSTECCNNHSLTDVCFSYRNNFNKRL------HTCLPARKAVEATQVCRSNKDCKSG- 376

  Fly   362 CNEGFCLRPLIRNITAIMTFKRQNFRGEKLPP---VIYVGHPWDVTRTVEVSAFVPRYSLLKAAW 423
            .:..||:.|.:...|.::..|.        ||   ::|||||..:..||.:::|:||::.|....
Mouse   377 ASSSFCIVPSLETHTRLIKVKH--------PPQIDMLYVGHPLHLHYTVSITSFIPRFNFLSIDL 433

  Fly   424 PDAWLLLLKYNVVFSIGLALINAIPCFGFDGAHITSTVIHSFLVGRVDQHAKRDIISLIITSVGS 488
            |......:||.:..|..||::||:|||..||..|.::.:.:.|...:..:..:|:|...|...||
Mouse   434 PVIVETFVKYLISLSGALAIVNAVPCFALDGQWILNSFLDATLTSVIGDNDVKDLIGFFILLGGS 498

  Fly   489 LLFALALLKVAWL 501
            :|.|..:....|:
Mouse   499 VLLAANVTLGLWM 511

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
S2P	NP_610705.1	S2P-M50	6..>218	CDD:299148	76/232 (33%)
		RseP	136..508	CDD:223821	116/377 (31%)
		S2P-M50	<427..494	CDD:299148	21/66 (32%)
Mbtps2	NP_758511.1	S2P-M50_PDZ_SREBP	14..>225	CDD:100083	70/214 (33%)
		PDZ	<251..>295	CDD:294084	17/44 (39%)
		S2P-M50	<415..504	CDD:100078	28/88 (32%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167830722
Domainoid	1	1.000	183	1.000	Domainoid score	I3435
eggNOG	1	0.900	-	-		E1_COG0750
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H9287
Inparanoid	1	1.050	251	1.000	Inparanoid score	I3205
Isobase	1	0.950	-	0	Normalized mean entropy	S7377
OMA	1	1.010	-	-		QHG55798
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0006242
OrthoInspector	1	1.000	-	-		oto92592
orthoMCL	1	0.900	-	-		OOG6_103384
Panther	1	1.100	-	-	LDO	PTHR13325
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R9506
SonicParanoid	1	1.000	-	-		X4524
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	16	15.740