DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Sobp and sobpa

DIOPT Version :9

Sequence 1:	NP_001286320.1	Gene:	Sobp / 36260	FlyBaseID:	FBgn0033654	Length:	813	Species:	Drosophila melanogaster
Sequence 2:	NP_001092088.1	Gene:	sobpa / 573683	ZFINID:	ZDB-GENE-090313-313	Length:	936	Species:	Danio rerio

Alignment Length:	950	Identity:	235/950 - (24%)
Similarity:	332/950 - (34%)	Gaps:	338/950 - (35%)

- Green bases have known domain annotations that are detailed below.

  Fly    22 ESRKANFSPES----YIPHPVEMSAKTSPSSTSRDANVGSSSAIPVQIKKELP-----------S 71
            |..|....|||    ...|||:           |:.|    :.:.|...:.||           |
Zfish     3 EMEKEGRPPESKRSRKPAHPVK-----------REIN----AEMKVPSNRPLPGAGQAGNLHGNS 52

  Fly    72 DEIKEFAHNTMNELLGWYGFEGVDV-DRLDLTAKTSRLLQSAAAAAVANQQSHQLHQLEPHPNLE 135
            ..:..||.|||||||||||::.|:: |..|:                         ::..:|:.|
Zfish    53 PYLMSFAENTMNELLGWYGYDKVELRDSDDI-------------------------EIRNYPDGE 92

  Fly   136 -RKRTSLLRSSSRSSLAAAYHNNNNNNNNNNNGSSSKNNGGVGGVGVGSGRKSGLMNCSSTTTTP 199
             |:..|:|:.:|....:...:::.:..:.|::||:..:..||                    |..
Zfish    93 MRQHISVLKENSLPKASTLENSSGSPPHANSSGSTPTSRNGV--------------------TAE 137

  Fly   200 SDHDTRSSREEDSK-------SPHSIGKPAGAAHTDEKIDFSN----CCWCHRPIAENAPDYLTS 253
            |..:..||:|....       .|..|..||       :.|.||    |.||.: :..........
Zfish   138 SSVNPSSSKEHGGLPIIVPLIPPPLIKAPA-------EEDSSNVQIMCAWCQK-VGVKRYSLSMG 194

  Fly   254 CDGPRYCSESCFAQSRRASFKKAK------------------------------------TCDWC 282
            .:...:|||.|||..|||.||:.|                                    .||||
Zfish   195 SELKSFCSEKCFAACRRAYFKRNKLGYVRNCSAREEEGVPTHSLSKDTPRLVLKTNSDVLVCDWC 259

  Fly   283 KHVRHAVSYVDFQDGASQLQFCSEKCLNQYKMQIFCHETQAHLD---MHPHL--RDQAMDAGSEA 342
            ||:||...|:||..|..:|||||.||||||||.||..||||.|.   .:|.|  .|...::|:..
Zfish   260 KHIRHTKEYLDFGAGERRLQFCSAKCLNQYKMDIFYKETQAALPGGLCNPPLPTSDTKSESGAGV 324

  Fly   343 GLITPDLWLRNCRSRSASPASTLSVSPGPPPAPAVSRCPDSPPSHHPSKP----LISVAPVSKLL 403
            .|:||:.|        ::|.|.|.....|.|..|....|....|..||:.    ..|.:..|...
Zfish   325 QLLTPESW--------SAPLSELRSRKAPSPVGATIAGPSGSTSGSPSEAGTVCSSSSSSSSSSS 381

  Fly   404 AQKSPGP----GPGAPPPPPPPVQRHLAGKLGRRKRRGISSSLGSETVASLLQKQQQQQAPQQHQ 464
            :.|.|.|    .|..|||.|||:.             |:..:||
Zfish   382 STKIPTPRPHESPSLPPPHPPPIS-------------GLHPALG--------------------- 412

  Fly   465 APPTLTADFGGSSVPLPPLSPMP---SMQEAPQQQQAPQV--PPTQALPR--------GPTAIPA 516
            .||      |...:.:.|..|:|   .|:....||..|..  ||....|.        ||...|.
Zfish   413 MPP------GSPPMVMTPRGPVPFPIFMEHQMMQQMRPPFLRPPGPNSPHSNPMIPGIGPPPPPR 471

  Fly   517 SYFATPSNGV------PMGHP-----FAGRPP--PPPHHFMHP-----PPHGMMPRGFGPHFGP- 562
            : ...||:.:      |..||     .:|.||  .|||...|.     ||..|||.      ||
Zfish   472 T-LCPPSSPMHRPLLSPHLHPSSTPTLSGNPPGIMPPHPAAHMPGLPFPPVNMMPS------GPI 529

  Fly   563 PLPP----QMPELGSLLGAVPPVTVMVPYPIIIPLPIPIPVPLPVIDFYKAHLTPEERKRFDEQR 623
            |:||    .||.|..|   |||.|::||||:|:|||:|||:|:|:              .::.||
Zfish   530 PVPPIMNIGMPSLAPL---VPPPTLLVPYPVIVPLPVPIPIPVPI--------------PYNPQR 577

  Fly   624 AA---------PTRAENAEEQEQPQPLDCSKSRSELEEEKPDVEKLSEPGQELDNDQEEDEKESI 679
            :.         |..|...::.:.|..........:.::..|:.:.||               ...
Zfish   578 SGDRPGNDGTLPNTANEQKDSKAPPSFSSRGEERDFQKAPPNSDTLS---------------PEF 627

  Fly   680 PKTNPDGDTNAASPSISQESSSSPQQTHCIVRDSTQSEPEADNQKLPKLKITRLQTKRTLIQTKE 744
            .|....|.||.|...:..|:|......|      :..:..||.  :..|..:....::.:||
Zfish   628 SKQTEQGRTNMADLMVKMENSGKGSSEH------SHKDTPADG--VIDLTTSHRSRQQLVIQ--- 681

  Fly   745 AAAECSRPLRKRKRIIDCDFQKM--GLKEP-----EMANDGEQSNGS-----------SNKEAD- 790
                         |.:.|...|.  ||..|     |...||..|..:           ||.|:.
Zfish   682 -------------RAVTCVQVKAEPGLSPPPALLGETELDGSTSISTGTAKDDHRDTYSNAESPL 733

  Fly   791 -------ADPE-----------AECNMSGSHSNSGSAKAK 812
                   |||.           ..|:.|...||..:||.:
Zfish   734 ASVALPCADPSYCSGTPPLSQPITCSASIIPSNITTAKTE 773

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Sobp	NP_001286320.1	Ribosomal_L24e_L24	275..312	CDD:294589	22/72 (31%)
Sobp	NP_001286320.1	SOBP	278..587	CDD:291927	112/357 (31%)
sobpa	NP_001092088.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..46		13/57 (23%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	108..151		10/62 (16%)
		SOBP	255..552	CDD:291927	111/354 (31%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	311..330		5/18 (28%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	336..424		27/127 (21%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	486..511		9/24 (38%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	574..632		9/72 (13%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	697..727		5/29 (17%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	842..877
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170574382
Domainoid	1	1.000	155	1.000	Domainoid score	I4198
eggNOG	1	0.900	-	-		E1_28SIJ
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	191	1.000	Inparanoid score	I3857
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0006985
OrthoInspector	1	1.000	-	-		otm26271
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	LDO	PTHR23186
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R5272
SonicParanoid	1	1.000	-	-		X5073
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	12	11.880