DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Sobp and Sobp

DIOPT Version :9

Sequence 1:	NP_001286320.1	Gene:	Sobp / 36260	FlyBaseID:	FBgn0033654	Length:	813	Species:	Drosophila melanogaster
Sequence 2:	NP_780616.4	Gene:	Sobp / 109205	MGIID:	1924427	Length:	864	Species:	Mus musculus

Alignment Length:	906	Identity:	238/906 - (26%)
Similarity:	330/906 - (36%)	Gaps:	310/906 - (34%)

- Green bases have known domain annotations that are detailed below.

  Fly    39 EMSAKTSPSSTSRDANVGSSSAIPVQIKKELPSDEIKEFAHNTMNELLGWYGF------EGVDVD 97
            ||..:..|....|    ....|.||  |:|: ::|:|.||.|||||||||||:      :|.|::
Mouse     3 EMEKEGRPPENKR----SRKPAHPV--KREI-NEEMKNFAENTMNELLGWYGYDKVELKDGEDIE 60

  Fly    98 RLDLTAKTSRLLQSAAAAAVANQQSHQLHQLEPHPNLERKRTSLLRSSSRSSLAAAYHNNNNNNN 162
            ....|...    :|....:|..:.|      .|.|.|  ...|::   |..:::..|......|.
Mouse    61 FRSYTTDG----ESRQHISVLKENS------LPKPKL--PEDSVI---SSYNISTGYSGLATGNG 110

  Fly   163 NNNNGSSSKNNGGVGGVGVGSGRKSGLMNCSSTTTTPSDHDTRSSREEDSKSPHSIGKPAGAAHT 227
            .:::.:.||::|.|..:               ....|               |..|..||
Mouse   111 LSDSPAGSKDHGNVPII---------------VPLIP---------------PPFIKPPA----- 140

  Fly   228 DEKIDFSN----CCWCHRPIAENAPDYLTSCDGPRYCSESCFAQSRRASFKKAK----------- 277
              :.|.||    |.||.: :...........:...:|||.|||..|||.||:.|
Mouse   141 --EDDVSNVQIMCAWCQK-VGIKRYSLSMGSEVKSFCSEKCFAACRRAYFKRNKARDEDGRAETF 202

  Fly   278 ---------------------TCDWCKHVRHAVSYVDFQDGASQLQFCSEKCLNQYKMQIFCHET 321
                                 .||||||:||...|:||.||..:|||||.||||||||.||..||
Mouse   203 PQQHYAKETPRLAFKNNCELLVCDWCKHIRHTKEYLDFGDGERRLQFCSAKCLNQYKMDIFYKET 267

  Fly   322 QAHL------DMHPHLRDQAMDAGSEAGLITPDLW---LRNCRSRSASPASTLSVSPGPPPAPAV 377
            ||:|      .:|||:..:|...|.:  |:|||.|   |.:.|.::.||.:....|.||.|:.:.
Mouse   268 QANLPAGLCSTLHPHMESKAEGTGVQ--LLTPDSWNIPLTDARRKAPSPVTAAGQSQGPGPSSST 330

  Fly   378 SRCPDS-----------------PPSHHPSKPLISVAPVSKLLAQKSPGPGPGAPPPPPPPVQRH 425
            :..|..                 |.|..||.|.:||.|.:.:      ||..|.||..||.|.
Mouse   331 TVSPSDTANCSVTKIPTPVPKSLPISETPSIPPVSVQPPASI------GPPLGVPPRSPPMVM-- 387

  Fly   426 LAGKLGRRKRRGISSSLGSETVASLLQKQQQQQAPQQHQAPPTLTADFGGSSVPLPPLS-PM-PS 488
                          ::.|...:...:::|..||.     .||.:......:|.|..||| || |.
Mouse   388 --------------TNRGPVPLPIFMEQQIIQQI-----RPPFIRGPPHHASNPNSPLSNPMLPG 433

  Fly   489 MQEAPQQQQAPQVPPTQALPRGPTAIP------ASYFATPSNGVPMGHPFAGRPPPPPHHFMHP- 546
            :          ..||......|||:.|      :.:...||.....|:|....|||||...:..
Mouse   434 I----------GAPPGGPRNLGPTSSPMHRPMLSPHIHPPSTPTMPGNPPGLLPPPPPGAPLPSL 488

  Fly   547 --PPHGMMPRGFGPHFGPPLP-PQMPELG--SLLGAVPPVTVMVPYPIIIPLPIPIPVPLPVIDF 606
              ||..|||.|       |:| |||...|  ||...|||.|::||||:|:|||:|||:|:|:
Mouse   489 PFPPVSMMPNG-------PMPVPQMMNFGLPSLAPLVPPPTLLVPYPVIVPLPVPIPIPIPI--- 543

  Fly   607 YKAHLTPEERKRFDEQRAAPTRAENAEEQEQPQPLDCSKSRSELEEEKPDVEKLSEPGQELDNDQ 671
                                                            |.|.....|.....|.
Mouse   544 ------------------------------------------------PHVNDSKPPNGFSSNG- 559

  Fly   672 EEDEKESIPKTNPDGDTNAA---------SPSISQESSSSPQQTHCIVRDSTQSEPEADNQKLPK 727
                 ||...:.| ||::||         ||..|::.||.          |..|.|.:..|.|..
Mouse   560 -----ESFVPSAP-GDSSAAGGKAGGRSLSPRDSKQGSSK----------SADSPPGSSGQALSL 608

  Fly   728 LKITRLQ------TKRTLIQTKEAAAECSRP-----------------LRKRKRIIDCDFQKM-- 767
            ....|.:      |:|    ....|....:|                 :..|.|:.:...:.:
Mouse   609 APAERGRGEVVDLTRR----AGSPAGAGGQPGFAGVLHGPQDGVIDLTVGHRARLHNVIHRALHA 669

  Fly   768 ---GLKEPEMA--------NDGEQS---NGSSNKEADADPE--AECNMSGSHSNSGSAKAK 812
               ..:||..|        .||..|   .|.....|.|.||  |.||:..:.:.|..|:||
Mouse   670 HVKAEREPGAAERRTCGGCRDGHCSPPAAGDPGPGAPAGPEAAAACNVIVNGTRSAPAEAK 730

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Sobp	NP_001286320.1	Ribosomal_L24e_L24	275..312	CDD:294589	23/68 (34%)
Sobp	NP_001286320.1	SOBP	278..587	CDD:291927	116/348 (33%)
Sobp	NP_780616.4	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..25		4/21 (19%)
		PGF_pre_PGF	<59..>114	CDD:275058	10/54 (19%)
		SOBP	224..524	CDD:291927	115/368 (31%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	304..355		17/70 (24%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	413..484		19/78 (24%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	550..615		12/64 (19%)
		SUMO interaction motif 1 (SIM), mediates the binding to polysumoylated substrates. /evidence=ECO:0000250	618..622		1/3 (33%)
		SUMO interaction motif 2 (SIM), mediates the binding to polysumoylated substrates. /evidence=ECO:0000250	648..652		2/3 (67%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	725..751		7/41 (17%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167831372
Domainoid	1	1.000	176	1.000	Domainoid score	I3622
eggNOG	1	0.900	-	-		E1_28SIJ
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	204	1.000	Inparanoid score	I3730
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0006985
OrthoInspector	1	1.000	-	-		oto93241
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	LDO	PTHR23186
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R5272
SonicParanoid	1	1.000	-	-		X5073
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	13	12.880