DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Sobp and RAI2

DIOPT Version :9

Sequence 1:	NP_001286320.1	Gene:	Sobp / 36260	FlyBaseID:	FBgn0033654	Length:	813	Species:	Drosophila melanogaster
Sequence 2:	NP_001166210.2	Gene:	RAI2 / 10742	HGNCID:	9835	Length:	530	Species:	Homo sapiens

Alignment Length:	450	Identity:	107/450 - (23%)
Similarity:	162/450 - (36%)	Gaps:	134/450 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly   326 DMHPHLRDQAMDAGSEAGLITPDLWLRNCRSRSASPASTLSVSPGPPPAPAVSRCPDSPPSHHPS 390
            |..|.|.:..::.|. |.|||.:.|  |..|......:.::|     |||::.    :||:...|
Human    15 DSPPALANNRLENGM-AQLITTEAW--NINSTDLVKKALVTV-----PAPSIL----NPPAESQS 67

  Fly   391 KPLISVAP--VSKLLAQKSPGPGP------GAPPPPPPPVQRHLAGKLGRRKRRGISSSLGSETV 447
            ...:.||.  :..|...:||...|      |:..|...|                    .|:.|.
Human    68 GMALKVAATVLQPLCLGESPVVMPIHMQVEGSSAPELNP--------------------NGNATY 112

  Fly   448 ASLLQKQQQ-----QQAPQQHQAPPTLTADFGGSSVPLPPLSPMPS-------MQEAPQQQQAPQ 500
            ....|...|     :|...||...|.:          ||..:|..|       .|.|...:..||
Human   113 VMTTQGPVQLPVVLEQHVFQHLNSPLV----------LPQEAPCSSSTIHNNLFQGAEDPEAQPQ 167

  Fly   501 V----PPTQALPRGPT----AIPASYFATPSNGVPMGHPFAGRPPPPPHHFMHPPPHGMMPRGFG 557
            :    .|:|  |:.||    |:..:.|  ||.|. :|        |||   ..|||      |:.
Human   168 LLDLRIPSQ--PQEPTLPFEAVLQNLF--PSQGT-LG--------PPP---CQPPP------GYA 210

  Fly   558 PHFGPPLPPQMPELGSLLGAVPPVTVMVPYPIIIPLPIPIPVPLPVIDFYKAHLTPEERKRFDEQ 622
                 |:||| |....|...|||.|::||||:|:|||:|:|:|:|:      .:......:|...
Human   211 -----PVPPQ-PFSSPLSPLVPPATLLVPYPVIVPLPVPVPIPIPI------PMPQSSESKFSSS 263

  Fly   623 RAAPTRA---------ENAEEQEQPQPLDCSKSRSELEEEKPDVEKLSEPGQELDNDQEEDEKES 678
            ...|..:         :...|:::.:|.|..:.:...:..:..|.|:....:.||...     :|
Human   264 FPKPPSSFGLHPFKGTQTPLEKDELKPFDILQPKEYFQLSRHTVIKMGSENEALDLSM-----KS 323

  Fly   679 IPKTNPDGDTNAASPSISQE------------SSSSPQQTHCIVRDSTQSEPEADNQKLP 726
            :|...    ....||.|.||            .|..|.:|......|..|......:|||
Human   324 VPWLK----AGEVSPPIFQEDAALDLSVAAHRKSEPPPETLYDSGASVDSSGHTVMEKLP 379

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Sobp	NP_001286320.1	Ribosomal_L24e_L24	275..312	CDD:294589
Sobp	NP_001286320.1	SOBP	278..587	CDD:291927	72/288 (25%)
RAI2	NP_001166210.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..22		3/6 (50%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165141430
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR23186
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	3.030