DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment wal and ETFA

DIOPT Version :9

Sequence 1:	NP_476975.1	Gene:	wal / 36252	FlyBaseID:	FBgn0010516	Length:	330	Species:	Drosophila melanogaster
Sequence 2:	NP_000117.1	Gene:	ETFA / 2108	HGNCID:	3481	Length:	333	Species:	Homo sapiens

Alignment Length:	328	Identity:	229/328 - (69%)
Similarity:	271/328 - (82%)	Gaps:	2/328 - (0%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MF-ASNTRNLMRSSILQRCKSTLVVAEHNNEVLNPITLNTISAAKKIGGDVTVLVAGTKCGPASE 64
            || |:....|.|::.|.|.:||||:|||.|:.|.|||||||:||.::||:|:.|||||||...::
Human     1 MFRAAAPGQLRRAASLLRFQSTLVIAEHANDSLAPITLNTITAATRLGGEVSCLVAGTKCDKVAQ 65

  Fly    65 ALSKVDGVTKVLVAENAAFNGFTAESLTPLVLAAQSQFKFTHILAGASAFGKNVLPRVAAKLDVS 129
            .|.||.|:.|||||::..:.|...|.||||:||.|.||.:|||.|||||||||:||||||||:|:
Human    66 DLCKVAGIAKVLVAQHDVYKGLLPEELTPLILATQKQFNYTHICAGASAFGKNLLPRVAAKLEVA 130

  Fly   130 PISEIIDVKSDDTFVRTIYAGNAILTLKSKDAVKVITVRSTNFPPAATSGGSGAVEQAPAGDFAS 194
            |||:||.:||.||||||||||||:.|:|..:.|||.:||.|:|..|||||||.:.|:| :.....
Human   131 PISDIIAIKSPDTFVRTIYAGNALCTVKCDEKVKVFSVRGTSFDAAATSGGSASSEKA-SSTSPV 194

  Fly   195 SLSEFVSQELTKSDRPELAGAKVIVSGGRGLKSGDNFKLLYDLADKFGAAVGASRAAVDAGFVPN 259
            .:||::.|:|||||||||.||||:||||||||||:||||||||||:..|||||||||||||||||
Human   195 EISEWLDQKLTKSDRPELTGAKVVVSGGRGLKSGENFKLLYDLADQLHAAVGASRAAVDAGFVPN 259

  Fly   260 DLQIGQTGKIVAPELYIAVGISGAIQHLAGMKDSKTIVAINKDPEAPIFQVADIGIVADLFKAVP 324
            |:|:|||||||||||||||||||||||||||||||||||||||||||||||||.||||||||.||
Human   260 DMQVGQTGKIVAPELYIAVGISGAIQHLAGMKDSKTIVAINKDPEAPIFQVADYGIVADLFKVVP 324

  Fly   325 ELT 327
            |:|
Human   325 EMT 327

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
wal	NP_476975.1	PLN00022	11..330	CDD:215032	225/317 (71%)
		ETF_alpha	20..188	CDD:238848	105/167 (63%)
		ETF_alpha	211..293	CDD:279150	73/81 (90%)
ETFA	NP_000117.1	PLN00022	3..333	CDD:215032	227/326 (70%)
		Domain I. /evidence=ECO:0000269\|PubMed:8962055	20..204		109/184 (59%)
		Domain II. /evidence=ECO:0000269\|PubMed:8962055	205..333		112/123 (91%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	206	1.000	Domainoid score	I2921
eggNOG	1	0.900	-	-		E1_COG2025
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H100
Inparanoid	1	1.050	437	1.000	Inparanoid score	I1696
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG53915
OrthoDB	1	1.010	-	-		D1128607at2759
OrthoFinder	1	1.000	-	-		FOG0003377
OrthoInspector	1	1.000	-	-		oto91298
orthoMCL	1	0.900	-	-		OOG6_101090
Panther	1	1.100	-	-	LDO	PTHR43153
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R418
SonicParanoid	1	1.000	-	-		X2274
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	15	14.870