DRSC/TRiP Functional Genomics Resources

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Protein Alignment Buffy and BCL2

DIOPT Version :10

Sequence 1:NP_523702.1 Gene:Buffy / 36251 FlyBaseID:FBgn0040491 Length:299 Species:Drosophila melanogaster
Sequence 2:NP_000624.2 Gene:BCL2 / 596 HGNCID:990 Length:239 Species:Homo sapiens


Alignment Length:153 Identity:39/153 - (25%)
Similarity:64/153 - (41%) Gaps:25/153 - (16%)


- Green bases have known domain annotations that are detailed below.


  Fly   125 GSTSMGIVRDVFPAVQV----LGDELERMHPRIYNGVARQICRNP---GGEFHTPDAVSLLLGAV 182
            |:.:...:..|.|.|.:    .||:..|.:.|.:..::.|:...|   .|.|.|          |
Human    79 GAAAGPALSPVPPVVHLTLRQAGDDFSRRYRRDFAEMSSQLHLTPFTARGRFAT----------V 133

  Fly   183 GRELFRVEITWSKVISLFAIAGGLSVDCVRQGHPEYLPKLMESV----SEVIEDELVPWINENGG 243
            ..||||..:.|.::::.|...|   |.||...:.|..| |::::    :|.:...|..||.:|||
Human   134 VEELFRDGVNWGRIVAFFEFGG---VMCVESVNREMSP-LVDNIALWMTEYLNRHLHTWIQDNGG 194

  Fly   244 WSGINTHVLPTTNSLNPLEWTTL 266
            |........|:...|....|.:|
Human   195 WDAFVELYGPSMRPLFDFSWLSL 217

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
BuffyNP_523702.1 Bcl-2_like 99..250 CDD:132900 35/135 (26%)
BCL2NP_000624.2 bcl-2 1..239 CDD:273308 39/153 (25%)
BH4. /evidence=ECO:0000255|PROSITE-ProRule:PRU00025 10..30
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 39..85 1/5 (20%)
Required for interaction with SEPTIN4 isoform ARTS. Required XIAP-mediated ubiquitination and apoptosis. /evidence=ECO:0000269|PubMed:29020630 92..107 3/14 (21%)
BH3. /evidence=ECO:0000255 93..107 3/13 (23%)
BH1. /evidence=ECO:0000255 136..155 6/18 (33%)
BH2. /evidence=ECO:0000255 187..202 6/14 (43%)
Blue background indicates that the domain is not in the aligned region.

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