DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Tret1-2 and HXT5

DIOPT Version :9

Sequence 1:	NP_610694.1	Gene:	Tret1-2 / 36249	FlyBaseID:	FBgn0033644	Length:	488	Species:	Drosophila melanogaster
Sequence 2:	NP_011964.1	Gene:	HXT5 / 856496	SGDID:	S000001138	Length:	592	Species:	Saccharomyces cerevisiae

Alignment Length:	496	Identity:	135/496 - (27%)
Similarity:	218/496 - (43%)	Gaps:	60/496 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly    33 LSVSLCSLVV---GFVSAY---TSPALVSMTDRTITSFEVTKDAGS---------WVGGIMPLAA 82
            |.||:|.|:|   |||..:   |....|..|| .|..|..|:..|:         .:..|..:..
Yeast    84 LFVSVCCLMVAFGGFVFGWDTGTISGFVRQTD-FIRRFGSTRANGTTYLSDVRTGLMVSIFNIGC 147

  Fly    83 LAGGITGGPLIEYLGRRSTILATAVPFIVSSLL-IACAVNVIMILCGRFLTGFCVGIASLSLPVY 146
            ..|||....|.:..||:..::...|.:.:..:: ||..........||.::|..||..::..|:.
Yeast   148 AIGGIVLSKLGDMYGRKIGLMTVVVIYSIGIIIQIASIDKWYQYFIGRIISGLGVGGITVLAPML 212

  Fly   147 LGETLQPEVRGTLGLLPTALGNIGILVCYVA-------GSFMNWSMLAFLGAALPVPFLILMIII 204
            :.|....::||||......:...||.:.|..       .:.:.|.:...|..|..:..::.|..:
Yeast   213 ISEVSPKQLRGTLVSCYQLMITFGIFLGYCTNFGTKNYSNSVQWRVPLGLCFAWSIFMIVGMTFV 277

  Fly   205 PETPRWFVNRGQEERARKALKWLRGKEADVEPEL----KELMQSQADADRQATQNTCLEL----- 260
            ||:||:.|..|:.|.|:::|  .|..:...:..|    .|..||..:|:|.|...:..||
Yeast   278 PESPRYLVEVGKIEEAKRSL--ARANKTTEDSPLVTLEMENYQSSIEAERLAGSASWGELVTGKP 340

  Fly   261 --FKRNNLKPLSISLGLMF--FQQFSGINAVIFYTVQIFKDAGSTIDSNLSTIIVGVVNFFATFM 321
              |:|.       .:|:|.  .||.:|.|...:|...||:..|.. ||..:.|::|||||.:||.
Yeast   341 QMFRRT-------LMGMMIQSLQQLTGDNYFFYYGTTIFQAVGLE-DSFETAIVLGVVNFVSTFF 397

  Fly   322 GIILIDRLGRKILLYVSDIAMIVTLSILG--GFFYCKAHGPD-VSHLG----WLPLTCFVIYILG 379
            .:..:||.||:..|....:.||....:..  |......:|.| .|..|    .:...||  ||..
Yeast   398 SLYTVDRFGRRNCLLWGCVGMICCYVVYASVGVTRLWPNGQDQPSSKGAGNCMIVFACF--YIFC 460

  Fly   380 FSLGFGPIPWLMMGEILPAKIRGPAASVVTAFNWFCTFVVTKTFQDLTVAMGAHGAFWLFGAICI 444
            |:..:.|:.::::.|..|.::||.|.|:.:|.||...|:::.....:|.|:..:..:...|  |:
Yeast   461 FATTWAPVAYVLISESYPLRVRGKAMSIASACNWIWGFLISFFTPFITSAINFYYGYVFMG--CM 523

  Fly   445 V-GLFFVIIFVPETRGKSLEEIERKMMGRV-PMSSVVNIKP 483
            | ..|:|..|||||:|.:|||:.......| |..|...|.|
Yeast   524 VFAYFYVFFFVPETKGLTLEEVNEMYEENVLPWKSTKWIPP 564

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Tret1-2	NP_610694.1	Sugar_tr	31..467	CDD:278511	130/477 (27%)
Tret1-2	NP_610694.1	MFS	33..454	CDD:119392	121/464 (26%)
HXT5	NP_011964.1	Sugar_tr	89..549	CDD:395036	127/474 (27%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C157342778
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0254
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		mtm13432
orthoMCL	1	0.900	-	-		OOG6_100060
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X26
TreeFam	0	0.000	Not matched by this tool.
	6	5.640